MIT study: 24-hour fasting regenerates stem cells, doubles metabolism
This gives credence to the 5-2 diet, which has recently gained in popularity thanks to a large celebrity following.
Chances are you're probably thinking about food right now in some capacity. Maybe it's close to dinner and you're wondering what you are going to eat. Maybe you had a really good lunch and are fondly reminiscing about your BLT, or whatnot. Or maybe, just maybe, you're thinking about not eating food for a while.
If you're thinking about the latter, researchers at MIT have discovered that fasting for 24 hours flips a metabolic switch in mice, causing their guts to enhance their intestinal stem cells. Intestinal stem cells are what powers the intestine, and as people age this powerhouse starts to slow down. Ever wonder why you put on more weight as you get older? Thank your gut flora, including these cells.
The researchers found that fasting for just one day caused intestinal cell regeneration to double. While the trial has yet to be performed on humans, the biology behind these stem cells isn't wildly different to ours at all.
So, even though a 24 hour fast might make you hangry (hungry + angry, duh), it looks like it will undoubtedly speed up your metabolism. These cells regenerate on their own roughly every 4 days, so while it isn't our place at all to tell you how to diet much less tell you that fasting will work for everybody, the science is in. And celebrities like Jimmy Kimmel and Benedict Cumberbatch have kept the pounds off over the years thanks to intermittent short fasts. One of the most popular of these diets is the 5-2 diet, which allows 5 days of eating normally and 2 days of severe caloric restrictions of 600 calories or less on the fasting days.
Those with diabetes or metabolic diseases should definitely consult a doctor before jumping in the deep and attempting a somewhat extreme diet. It's not for everyone, but the results achieved by the fasting appear to mimic cell autophagy, or "cellular cleaning" of damaged cells.
Not bad for just withholding, eh?
The new version's battery has a shorter range and a price $4,000 lower than the previous starting price.
- Tesla's new version of the Model 3 costs $45,000 and can travel 260 miles on one charge.
- The Model 3 is the best-selling luxury car in the U.S.
- Tesla still has yet to introduce a fully self-driving car, even though it once offered the capability as an option to be installed at a future date.
"It's about having employees that are empowered."
Denmark may be the birthplace of the Lego tower, but its workplace hierarchy is the flattest in the world.
According to the World Economic Forum's Global Competitiveness Report 2018, the nation tops an index measuring "willingness to delegate authority" at work, beating 139 other countries.
We all know sleeping with your ex is a bad idea, or is it?
- In the first study of its kind, researchers have found sex with an ex didn't prevent people from getting over their relationship.
- Instead of feeling worse about their breakup after a hookup, the new singles who attempted sexual contact with their ex reported feeling better afterwards.
- The findings suggest that not every piece of relationship advice is to be taken at face value.
Want a happy, satisfying relationship? Psychologists say the best way is to learn to take a joke.
- New research looks at how partners' attitudes toward humor affects the overall quality of a relationship.
- Out of the three basic types of people, people who love to be laughed at made for better partners.
- Fine-tuning your sense of humor might be the secret to a healthy, happy, and committed relationship.
It's hard to imagine such a number. But these images will help you try.
The Mega Millions lottery just passed $1 billion for tonight's drawing.
What does that even look like, when represented by various currencies?
It takes just 6 numbers to win. You can only, however, purchase tickets up until 10:45 ET tonight.
Tiny and efficient, these biodegradable single cells show promise as a way to target hard-to-reach cancers.
- Scientists in Germany have found a potential improvement on the idea of bacteria delivering medicine.
- This kind of microtargeting could be useful in cancer treatments.
- The microswimmers are biodegradable and easy to produce.
Metin Sitti and colleagues at the Max Planck Institute in Germany recently demonstrated that tiny drugs could be attached to individual algae cells and that those algae cells could then be directed through body-like fluid by a magnetic field.
The results were recently published in Advanced Materials, and the paper as a whole offers up a striking portrait of precision and usefulness, perhaps loosely comparable in overall quality to recent work done by The Yale Quantum Institute. It begins by noting that medicine has been attached to bacteria cells before, but bacteria can multiply and end up causing more harm than good.
A potential solution to the problem seems to have been found in an algal cell: the intended object of delivery is given a different electrical charge than the algal cell, which helps attach the object to the cell. The movement of the algae was then tested in 2D and 3D. (The study calls this cell a 'microswimmer.') It would later be found that "3D mean swimming speed of the algal microswimmers increased more than twofold compared to their 2D mean swimming speed." The study continues —
More interestingly, 3D mean swimming speed of the algal microswimmers in the presence of a uniform magnetic field in the x-direction was approximately threefolds higher than their 2D mean swimming speed.
After the 2D and 3D speed of the algal was examined, it was then tested in something made to approximate human fluid, including what they call 'human tubal fluid' (think of the fallopian tubes), plasma, and blood. They then moved to test the compatibility of the microswimmer with cervical cancer cells, ovarian cancer cells, and healthy cells. They found that the microswimmer didn't follow the path of bacteria cells and create something toxic.
The next logical steps from the study include testing this inside a living organism in order to assess the safety of the procedure. Potential future research could include examining how effective this method of drug delivery could be in targeting "diseases in deep body locations," as in, the reproductive and gastrointestinal tracts.
Our modern-day Kafka on his new novel Lake Success and the dark comedy that in 2018 pretty much writes itself
- riding the Greyhounds of hell, from New York to El Paso
- the alternate reality of hedge fund traders
Here's why the school you went to is less relevant than ever.
- Learning agility is the ability to learn new things quickly and be aware of the trends that are emerging in your industry. It's the most important job skill hiring managers should be looking for and job seekers should be putting forward, says Kelly Palmer.
- Want to test your learning agility? Answer this practice interview question: "What did you learn last week?"
- Hiring people based on the school they went to is less relevant than ever. Why? Palmer explains: "If I asked you, "Tell me about your health," and you told me you ran a marathon 10 years ago, does that really tell me what your health is like? Not really." It's what you can offer now and how agile you are that matters.
- Kelly Palmer is the author of The Expertise Economy.
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