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Psilocybin rapidly promotes neuroplasticity in the brains of rats
The compound found in "magic mushrooms" has significant and fast-acting impact on the brains of rats.
- Psilocybin and psilocin are chemical compounds found in "magic mushrooms."
- A recent study published in the Journal of Psychopharmacology found very interesting results when psilocybin was administered to rats to research the potential impact the chemical could have on the human brain.
- Several studies have suggested that psilocybin could be a treatment for depression.
A recent study published in the Journal of Psychopharmacology found very interesting results when psilocybin was administered to rats to research the potential impact the chemical could have on the human brain.
Psilocybin increases the expression of several genes related to neuroplasticity in the brain of rats after just one dose.
What is psilocybin?
Psilocybin and psilocin are chemical compounds found in "magic mushrooms." These are typically obtained from certain types of dried or fresh mushrooms found in places such as Mexico and South America. These compounds have a similar structure to lysergic acid diethylamide (LSD) and are often abused for their hallucinogenic and euphoric effects.
What is neuroplasticity?
Neuroplasticity is the ability of neural networks in the brain to change through both growth and reorganization, and the above increases/decreases of certain genes provoked by psilocybin is a form of neuroplasticity that happens in response to even small doses of psilocybin (magic mushrooms)
The study: magic mushrooms and the prefrontal cortex/hippocampus of rats
Psilocybin increases the expression of several genes related to neuroplasticity in the brain of rats after just one dose.
Photo by bukhta79 on Adobe Stock
The study examined the acute effects of a single dose (0.5-20mg/kg) of psilocybin on the brain of rats. In total, 45 genes and 8 reference genes were assessed using real-time quantitative polymerase chain reaction. The corresponding protein levels of the three most commonly regulated genes were then assessed using Western blotting.
In the prefrontal cortex, the drug increased the expression of the following:
- CEBPB (protein-coding gene)
- c-Fos (a proto-oncogene)
- DUSP-1 (protein-coding gene)
- FOSB (protein-coding gene)
- JunB (protein-coding gene)
- IkBa (inhibitor gene)
- Nr4a1 (growth factor gene)
- P11 (protein)
- Psd95 (protein)
- SGK1 (protein-coding gene)
The drug also decreased the expression of CLK1, an enzyme that, in humans, is encoded by the CLK1 gene.
In the hippocampus, psilocybin strongly increased the expression of:
The drug also decreased the expression of ARC (neuronal gene encoder), CLK1, EGR2 (protein-coding), and PTGS2 (protein-coding). The protein levels of certain genes (IkBa, DUSP1, and SGK1) showed only partial agreement with transcriptional patterns, which stresses the importance of assessing downstream translation with these kinds of rapid gene responses.
What does this mean?
This study demonstrates that psilocybin not only includes gene expression that's heavily related to neuroplasticity, but it does so as a very rapid response to the chemical. The results were biased towards the prefrontal cortex compared to the hippocampus, but the findings of this study provide undeniable evidence for the rapid plasticity-promoting effects of psilocybin.
Can magic mushrooms treat depression?
Several studies (including this one from 2017) have suggested that psilocybin could be a treatment for depression. In this study, 19 patients were given two incrementally larger doses of psilocybin administered one week apart. MRI scans were taken of the brains of patients before and after the doses were administered. The results of the study showed that the chemical reduced and then increased the amount of blood flow to (and thus changing the activity levels of) different regions of the brain, some of which are associated with depressive symptoms.
The patients of this study also self-reported improved mood spikes lasting for up to five weeks after the ingestion of psilocybin. The patients even explained that they felt as though their brains had been "reset" or "rebooted" - this effect being known (in unscientific settings) as the "afterglow" of psilocybin use.
Psychedelic drugs (like psilocybin) may hold untold potential in treating not only depression but anxiety and addiction, as well.
While researchers are still pursuing how psychedelics like psilocybin could be beneficial to human brains, there are some theories surrounding how psychedelics could help in addiction therapies.
"People will often report a changed relationship in observing themselves. I think this is much like what we refer to as mindfulness: someone's ability to view their own motivations and behaviour from a more detached and less judgemental perspective," said Matthew Johnson, a professor of psychology at Johns-Hopkins University who is testing psilocybin in a trial aimed at nicotine addiction.
- From mushrooms to ecstasy, a renaissance in psychedelics research ›
- Magic in those mushrooms: first psilocybin research center to open ... ›
- Psychedelics may be a powerful treatment for alcoholism - Big Think ›
A man's skeleton, found facedown with his hands bound, was unearthed near an ancient ceremonial circle during a high speed rail excavation project.
- A skeleton representing a man who was tossed face down into a ditch nearly 2,500 years ago with his hands bound in front of his hips was dug up during an excavation outside of London.
- The discovery was made during a high speed rail project that has been a bonanza for archaeology, as the area is home to more than 60 ancient sites along the planned route.
- An ornate grave of a high status individual from the Roman period and an ancient ceremonial circle were also discovered during the excavations.
An ancient skeleton of a man dating back to the Iron Age was uncovered outside of London last month, and though archaeologists aren't certain what the cause of death was, clues point to a murder most foul.
A skeleton representing a man who was tossed face down into a ditch nearly 2,500 years ago with his hands bound in front of his hips was dug up during a high speed rail excavation.
The positioning of the remains have led archaeologists to suspect that the man may have been a victim of an ancient murder or execution. Though any bindings have since decomposed, his hands were positioned together and pinned under his pelvis. There was also no sign of a grave or coffin.
"He seems to have had his hands tied, and he was face-down in the bottom of the ditch," said archaeologist Rachel Wood, who led the excavation. "There are not many ways that you end up that way."
Currently, archaeologists are examining the skeleton to uncover more information about the circumstances of the man's death. Fragments of pottery found in the ditch may offer some clues as to exactly when the man died.
"If he was struck across the head with a heavy object, you could find a mark of that on the back of the skull," Wood said to Live Science. "If he was stabbed, you could find blade marks on the ribs. So we're hoping to find something like that, to tell us how he died."
Other discoveries at Wellwick Farm
The grim discovery was made at Wellwick Farm near Wendover. That is about 15 miles north-west of the outskirts of London, where a tunnel is going to be built as part of a HS2 high-speed rail project due to open between London and several northern cities sometime after 2028. The infrastructure project has been something of a bonanza for archaeology as the area is home to more than 60 ancient sites along the planned route that are now being excavated before construction begins.
The farm sits less than a mile away from the ancient highway Icknield Way that runs along the tops of the Chiltern Hills. The route (now mostly trails) has been used since prehistoric times. Evidence at Wellwick Farm indicates that from the Neolithic to the Medieval eras, humans have occupied the region for more than 4,000 years, making it a rich area for archaeological finds.
Wood and her colleagues found some evidence of an ancient village occupied from the late Bronze Age (more than 3,000 years ago) until the Roman Empire's invasion of southern England about 2,000 years ago. At the site were the remains of animal pens, pits for disposing food, and a roundhouse — a standard British dwelling during the Bronze Age constructed with a circular plan made of stone or wood topped with a conical thatched roof.
Ceremonial burial site
A high status burial in a lead-lined coffin dating back to Roman times.
Photo Credit: HS2
While these ancient people moved away from Wellwick Farm before the Romans invaded, a large portion of the area was still used for ritual burials for high-status members of society, Wood told Live Science. The ceremonial burial site included a circular ditch (about 60 feet across) at the center, and was a bit of a distance away from the ditch where the (suspected) murder victim was uncovered. Additionally, archaeologists found an ornately detailed grave near the sacred burial site that dates back to the Roman period, hundreds of years later when the original Bronze Age burial site would have been overgrown.
The newer grave from the Roman period encapsulated an adult skeleton contained in a lead-lined coffin. It's likely that the outer coffin had been made of wood that rotted away. Since it was clearly an ornate burial, the occupant of the grave was probably a person of high status who could afford such a lavish burial. However, according to Wood, no treasures or tokens had been discovered.
Sacred timber circle
An aerial view of the sacred circular monument.
Photo Credit: HS2
One of the most compelling archaeological discoveries at Wellwick Farm are the indications of a huge ceremonial circle once circumscribed by timber posts lying south of the Bronze Age burial site. Though the wooden posts have rotted away, signs of the post holes remain. It's thought to date from the Neolithic period to 5,000 years ago, according to Wood.
This circle would have had a diameter stretching 210 feet across and consisted of two rings of hundreds of posts. There would have been an entry gap to the south-west. Five posts in the very center of the circle aligned with that same gap, which, according to Wood, appeared to have been in the direction of the rising sun on the day of the midwinter solstice.
Similar Neolithic timber circles have been discovered around Great Britain, such as one near Stonehenge that is considered to date back to around the same time.
Scientists should be cautious when expressing an opinion based on little more than speculation.
- In October 2017, a strange celestial object was detected, soon to be declared our first recognized interstellar visitor.
- The press exploded when a leading Harvard astronomer suggested the object to have been engineered by an alien civilization.
- This is an extraordinary conclusion that was based on a faulty line of scientific reasoning. Ruling out competing hypotheses doesn't make your hypothesis right.
Sometimes, when you are looking for something ordinary, you find the unexpected. This is definitely the case with the strange 'Oumuamua, which made international headlines as a potential interstellar visitor. Its true identity remained obscure for a while, as scientists proposed different explanations for its puzzling behavior. This is the usual scientific approach of testing hypotheses to make sense of a new discovery.
What captured the popular imagination was the claim that the object was no piece of rock or comet, but an alien artifact, designed by a superior intelligence.
Do you remember the black monolith tumbling through space in the classic Stanley Kubrick movie 2001: A Space Odyssey? The one that "inspired" our ape-like ancestors to develop technology and followed humanity and its development since then? What made this claim amazing is that it wasn't coming from the usual UFO enthusiasts but from a respected astrophysicist from Harvard University, Avi Loeb, and his collaborator Shmuel Bialy. Does their claim really hold water? Were we really visited by an alien artifact? How would we know?
A mystery at 200,000 miles per hour
Before we dive into the controversy, let's examine some history. 'Oumuamua was discovered accidentally by Canadian astronomer Robert Weryk while he was routinely reviewing images captured by the telescope Pan-STARRS1 (Panoramic Survey and Rapid Response System 1), situated atop the ten-thousand-foot Haleakala volcanic peak on the Hawaiian island of Maui. The telescope scans the skies in search of near-Earth objects, mostly asteroids and possibly comets that come close to Earth. The idea is to monitor the solar system to learn more about such objects and their orbits and, of course, to sound the alarm in case of a potential collision course with Earth. Contrary to the objects Weryk was used to seeing, mostly moving at about 40,000 miles per hour, this one was moving almost five times as fast — nearly 200,000 miles per hour, definitely an anomaly.
Intrigued, astronomers tracked the visitor while it was visible, concluding that it indeed must have come from outside our solar system, the first recognized interstellar visitor. Contrary to most known asteroids that move in elliptical orbits around the sun, 'Oumuamua had a bizarre path, mostly straight. Also, its brightness varied by a factor of ten as it tumbled across space, a very unusual property that could be caused either by an elongated cigar shape or by it being flat, like a CD, one side with a different reflectivity than the other. The object, 1I/2017 U1, became popularly known as 'Oumuamua, from the Hawaiian for "scout."
In their paper, Loeb and Bialy argue that the only way the object could be accelerated to the speeds observed was if it were extremely thin and very large, like a sail. They estimated that its thickness had to be between 0.3 to 0.9 millimeters, which is extremely thin. After confirming that such an object is robust enough to withstand the hardships of interstellar travel (e.g., collision with gas particles and dust grains, tensile stresses, rotation, and tidal forces), Loeb and Bialy conclude that it couldn't possibly be a solar system object like an asteroid or comet. Being thus of interstellar origin, the question is whether it is a natural or artificial object. This is where the paper ventures into interesting but far-fetched speculation.
I'm not saying it was aliens, but it was aliens
First, the authors consider that it might be garbage "floating in interstellar space as debris from advanced technological equipment," ejected from its own stellar system due to its non-functionality; essentially, alien space junk. Then, they suggest that a "more exotic scenario is that 'Oumuamua may be a fully operational probe sent intentionally to Earth vicinity by an alien civilization," [italicized as in the original] concluding that a "survey for lightsails as technosignatures in the solar system is warranted, irrespective of whether 'Oumuamua is one of them."
You can shoot down as many hypotheses as you want to vindicate yours, but this doesn't prove yours is the right one.
I have known Avi Loeb for decades and consider him a serious and extremely talented astrophysicist. His 2018 paper includes a suggestive interpretation of strange data that obviously sparks the popular imagination. Theoretical physicists routinely suggest the existence of traversable wormholes, multiverses, and parallel quantum universes. Not surprisingly, Loeb was highly in demand by the press to fill in the details of his idea. A book followed, Extraterrestrial: The First Sign of Intelligent Life Beyond Earth, and its description tells all: "There was only one conceivable explanation: the object was a piece of advanced technology created by a distant alien civilization."
This is where most of the scientific establishment began to cringe. One thing is to discuss the properties of a strange natural phenomenon and rule out more prosaic hypotheses while suggesting a daring one. Another is to declare to the public that the only conceivable explanation is one that is also speculative. An outsider will conclude that a reliable scientist has confirmed not only the existence of extraterrestrial life but of intelligent and technologically sophisticated extraterrestrial life with an interest in our solar system. I wonder if Loeb considered the impact of his words and how they reflect on the scientific community as a whole.
This is why aliens won't talk to us
Earlier this year, in a live public lecture hosted by the Catholic University of Chile, Avi Loeb locked horns with Jill Tarter, the scientist that is perhaps most identifiable as someone who spent her career looking for signs of extraterrestrial intelligence. (Coincidentally, I was the speaker that followed Loeb the next week in the same seminar series and was cautioned — along with the other panelists — to behave myself to avoid another showdown. I smiled, knowing that my topic was pretty tame in comparison. I mean, how can the limits of human knowledge compare with alien surveillance?)
The Loeb-Tarter exchange was awful and, it being a public debate, was picked up by the press. Academics can be rough like anyone else. But the issue goes deeper.
What scientists say matters. When should a scientist make public declarations about a cutting-edge topic with absolute certainty? I'd say never. There is no clear-cut certainty in cutting-edge science. There are hypotheses that should be tested more until there is community consensus. Even then, consensus is not guaranteed proof. The history of science is full of examples where leading scientists were convinced of something, only to be proven wrong later.
The epistemological mistake Loeb committed was to make an assertion that publicly amounted to certainty by using a process of elimination of other competing hypotheses. You can shoot down as many hypotheses as you want to vindicate yours, but this doesn't prove yours is the right one. It only means that the other hypotheses are wrong. I do, however, agree with Loeb when he says that 'Oumuamua should be the trigger for an increase in funding for the search for technosignatures, a way of detecting intelligent extraterrestrial life.
Even with six months' notice, we can't stop an incoming asteroid.
- At an international space conference, attendees took part in an exercise that imagined an asteroid crashing into Earth.
- With the object first spotted six months before impact, attendees concluded that there was insufficient time for a meaningful response.
- There are an estimated 25,000 near-Earth objects potentially threatening our planet.
The asteroid 2021 PDC was first spotted on April 19, 2021 by the Pan-STARRS project at the University of Hawaii. By May 2, astronomers were 100% certain it was going to strike Earth somewhere in Europe or northern Africa. On October 20, 2021, the asteroid plowed into Europe, taking countless lives.
There was absolutely nothing anyone could do to deflect it from its deadly course. Experts could only warn a panicking population to get out of the way as soon as possible, if it was possible.
The above scenario is the result of a recently concluded NASA thought experiment.
The question the agency sought to answer was this: If we discovered a potentially deadly asteroid destined to hit Earth in six months, was there anything we could do to prevent a horrifying catastrophe? The disturbing answer is "no," not with currently available technology.
While Europe can breathe easy for now, the simulation conducted by NASA/JPL's Center for Near Earth Object Studies and presented at the 7th IAA Planetary Defense Conference is troubling. Space agencies spot "near-Earth objects" (NEOs) all the time. Many are larger than 140 meters in size, which means they're potentially deadly.
Credit: ImageBank4U / Adobe Stock
"The level [at] which we're finding the 140-meter and larger asteroids remains pretty stable, at about 500 a year. Our projection of the number of these objects out there is about 25,000, and we've only found a little over one-third of those so far, maybe 38% or so," NASA's Planetary Defense Office Lindley Johnson tells Space.com.
With our current technology, spotting an NEO comes down to whether we just happen to have a telescope pointing in its direction. To remove humanity's blind spot, the Planetary Society — the same organization that deployed Earth's first light sails — is developing the NEO Surveyor spacecraft, which they plan to deploy in 2025. According to the Planetary Society, it will be able to detect 90 percent of NEOs of 140 meters or larger, a vast improvement.
How to move an asteroid
The DART spacecraft will attempt to deflect an asteroid.Credit: NASA
The NASA/JPL exercise made clear that six months is just not enough time with our current technology to prepare and launch a mission in time to nudge an NEO off its course. (Small course adjustments become significant over great distances, which is why "nudging" an asteroid is a potential strategy.)
What would such a mission look like? Hollywood aside — remember Armageddon?— we know of no good way to redirect an NEO headed our way. Experts believe that shooting laser beams at an incoming rock, exciting as it might look, is not a realistic possibility. Targeted nuclear blasts might work, but forget about landing Bruce Willis, Ben Affleck, and Liv Tyler on an asteroid to set off a course-altering bomb, especially just a month after its discovery (as was the case in the movie).
Another thing that might work is crashing a spacecraft into an NEO hard enough to shift its course. That's the idea behind NASA's Double Asteroid Redirection Test (DART). This mission will shoot a spacecraft at the (non-threatening) asteroid Dimorphos in the fall of 2022 in the hope of changing its trajectory.
The deadly asteroid's journey
The asteroid "2021 PDC" hit Europe in NASA's simulation.Credit: NASA/JPL
The harrowing "tabletop exercise," as NASA/JPL called it, took place across four days at the conference:
- Day 1, "April 19" — The asteroid named "2021 PDC" is discovered 35 million miles away. Scientists calculate it has a 1-in-20 chance of striking Earth.
- Day 2, "May 2" — Now certain that 2021 PDC will hit Earth, space mission designers attempt to dream up a response. They conclude that with less than six months to impact, there's not enough time to realistically mount a mission to disrupt the NEO's course.
- Day 3, "June 30" — Images from the world's four largest telescopes reveal the area in Europe that will be hit. Space-based infrared measurements narrow the object's size to between 35 and 700 meters. This would pack a similar punch as a 1.2-megaton nuclear bomb.
- Day 4, "October 14" — Six days before impact, the asteroid is just 6.3 million km from Earth. Finally, the Goldstone Solar System Radar has been able to assess the size of 2021 PDC. Scientists calculate the blast from the asteroid will be primarily confined to the border region between Germany, Czechia, Austria, Slovenia, and Croatia. Disaster response experts develop plans for addressing the human toll.
"Each time we participate in an exercise of this nature," says Johnson, "we learn more about who the key players are in a disaster event, and who needs to know what information, and when."
Practically speaking, little can be done to hurry technological development along other than budgeting more money toward that goal. Maybe we should have Bruce Willis on call, just in case.