Many vegetative patients are actually 'covertly conscious'

This unsettling new understanding of vegetative patients raises medical ethics issues.

Many vegetative patients are actually 'covertly conscious'
Photo by Daan Stevens on Unsplash
  • For a long time, doctors assessed whether patients were in vegetative states through behavioral tests.
  • However, brain scans have revealed that some of these patients are actually in a state of "covert consciousness."
  • Covertly conscious patients are aware of their surroundings, but cannot respond to external stimuli.


In 2005, a 23-year-old woman was caught in a traffic accident that gave her a traumatic brain injury. Her doctors diagnosed her as being in a vegetative state — that is, absent of awareness and responsiveness, but still able to keep her heart pumping, her lungs breathing, to fall asleep and become awake, and so on.

Five months after her accident, however, researchers conducted an experiment showing that she had not completely lost her conscious awareness. Using an fMRI, researchers asked her to imagine playing tennis or walking through her house. Though the patient had been unable to respond to any other cues, the fMRI showed that her brain lit up when asked to imagine these things, suggesting that she was, in fact, conscious to some degree — just unable to move her hands or open her eyes on command. This patient would be the first time that signs of consciousness were detected in an ostensibly vegetative state using fMRI.

The trouble with diagnosing vegetative states

Since then, more and more cases of this sort have come to light. In fact, over the years, researchers estimate that around 10 to 20 percent of supposedly vegetative patients in fact experience what's called "covert" consciousness. Patients with covert consciousness do not respond to behavioral tests of awareness yet show brain activity related to awareness. It is important to note that covertly conscious patients do not fail to respond to behavioral tests because they are paralyzed. Instead, they fail to respond because the parts of their brain that respond to stimuli are damaged — they can still move, and sometimes will, but typically not in response to external stimuli.

After a traumatic brain injury that lands a patient in an ostensibly vegetative state, many clinicians assume a poor prognosis. As a result, many families decide whether to keep their loved one on life support or to withdraw it within the first three days after admission.

"The problem with severe brain injury," said neuroscientist Nicholas Schiff in The Scientist, "is that you have people who all look the same who could have very different trajectories of recovery over time, response to treatment, or already achieved level of recovery." Better diagnostic tools are needed to "sort the variance and also to figure out who we should look at more closely and immediately."

A better method

A healthcare professional administers an EEG.

BSIP/Universal Images Group via Getty Images

Patients with covert consciousness have been shown to recover at higher rates than those in persistent vegetative states even though they appear to be the same from the outside. Deciding to pull the plug on a loved one is never an easy task, but the uncertainty of whether or not they are truly beyond help makes it even more difficult.

Fortunately, researchers are working on ways to improve diagnosing these cases of covert consciousness. While fMRIs were the original way that researchers detected covert consciousness, applying them in critical care settings can be challenging. Electroencephalographs (EEGs) are likely to be far more useful as a diagnostic tool.

The first large-scale demonstration of using EEGs to diagnose cases of covert consciousness was recently published in the New England Journal of Medicine, where doctors asked patients to move their hands (which neither vegetative nor covertly conscious patients can do), and then used machine learning to decipher their EEG readings to identify brain activity in response to the commands. Twelve months later, 44 percent of those patients who were detected to have some brain activity were no longer vegetative and could function independently compared to just 14 percent of patients with no sign of activity in the EEG.

"This is very big for the field," Nicholas Schiff told The New York Times. "The understanding that, as the brain recovers, one in seven people could be conscious and aware, very much aware, of what's being said about them, and that this applies every day, in every I.C.U. — it's gigantic."

Archaeologists identify contents of ancient Mayan drug containers

Scientists use new methods to discover what's inside drug containers used by ancient Mayan people.

A Muna-type paneled flask with distinctive serrated-edge decoration from AD 750-900.

Credit: WSU
Surprising Science
  • Archaeologists used new methods to identify contents of Mayan drug containers.
  • They were able to discover a non-tobacco plant that was mixed in by the smoking Mayans.
  • The approach promises to open up new frontiers in the knowledge of substances ancient people consumed.
Keep reading Show less

Why cities are critical to achieving a carbon-neutral world

In May 2018, the city of Paris set an ambition to be carbon-neutral by 2050.

Photo by Rodrigo Kugnharski on Unsplash
Technology & Innovation
  • Countries, governments and companies are aligning on a need for net-zero - and this is an opportunity to rethink decarbonizing our cities.
  • There is no "one-size-fits-all" solution – each city's needs must be at the heart of developing integrated energy solutions.
  • A city can only decarbonize through collaboration between government, the private sector, and local communities.
Keep reading Show less

Japanese government appoints new "Minister of Loneliness"

While not the first such minister, the loneliness epidemic in Japan will make this one the hardest working.

Minister Tetsushi Sakamoto

Photo by CHARLY TRIBALLEAU/AFP via Getty Images
Politics & Current Affairs
  • The Japanese government has appointed a Minister of Loneliness to implement policies designed to fight isolation and lower suicide rates.
  • They are the second country, after the U.K., to dedicate a cabinet member to the task.
  • While Japan is famous for how its loneliness epidemic manifests, it isn't alone in having one.
Keep reading Show less
Culture & Religion

How art and design can rebuild a community

MIT professor Azra Akšamija creates works of cultural resilience in the face of social conflict.

Quantcast