Can aging be reversed by getting blood transfusions from young people?

Vampires and the Fountain of Youth are living legends once again. New studies that hope to find youthful properties in the blood of humans under the age of 25. What could go wrong?

A nurse carrying out a blood test. (Photo by: BSIP/UIG via Getty Images)


Silicon Valley bigwig Peter Thiel is a big fan of immortality. He’s using a lot of his biotech fortune to fund research aiming to reverse and ultimately stop the biological deterioration also known as aging. His latest idea is to inject young people’s blood into himself. If that sounds like modern-day vampirism, you’re correct.

Almost every culture in the world has a version of the vampire myth. In all of them, the vampire must ingest the blood of the living in order to retain its immortality. While humans created the monster, the belief in the life-giving properties of blood has been with us for millennia.

The first researcher to figure this out was Wanda Ruth Lunsford. She was a 26-year-old scientist working in New York City. She put an old rat and a young rat to sleep and tied their skin together. The rats’ blood supplies joined, and after several weeks the old rat had new neurons growing in its brain. The old rat also had a stronger heartbeat, bigger muscles, and brown hair instead of gray hair. Those results made Lunsford believe young blood could scientifically reverse the aging process. Professor David Agus backs her up:

While Lunsford was run out of the scientific community, scientists found her conclusions compelling. This year, laboratories at Harvard, Stanford, and University of California San Francisco not only repeated her experiment; it replicated her results. The exact reasons for those results are unclear, but the most likely culprit may be blood plasma.

Additional scientific testing on mice has shown that giving old mice blood plasma from young mice improves muscle function, cognition, and even sense of smell. Even more striking, those same studies showed that transfusing old blood into young mice sped up signs of aging. The results happened whether the mice’s circulatory systems were surgically combined or simple injections of blood plasma, but further tests are needed to determine why.

Yet one of the key culprits of blood plasma that may be causing these results is its ability to transport stem cells. Stem cells, according to The Mayo Clinic, are “the body's raw materials — cells from which all other cells with specialized functions are generated.” Those cells can generate new cells, and those cells “can either become new stem cells (self-renewal) or specialized cells (differentiation) with a more specific function, such as blood cells, brain cells, heart muscle or bone. No other cell in the body has the natural ability to generate new cell types.”

Stem cells are important and powerful -- but as Dr. Agus explains in the video above, they shut off at age 25. That’s why researchers are now focusing on blood transfusions from people under that age. One US company pursuing this research is Ambrosia, who hopes to inject 35-year-olds with the blood plasma of 25-year-olds. They’re hoping to examine the effects of those stem cells in the older participants, and are currently hoping to recruit 600 volunteers. Given that they’re charging participants $8,000 for each injection, their participant list may be skewed toward the Silicon Valley crowd. Similar studies in China and Korea are pursuing this line of research, too, albeit without the steep cost.

The science may sound more like fiction than fact, but it’s not. The FDA has approved blood for off-label prescription uses, provided its results are not guaranteed. That clearance, combined with the fact that the majority of the funds for this research are being provided by Silicon Valley, means blood might become a premium anti-aging treatment solely for the uber-rich. Putting that kind of medicine in the hands of people paying for its outcome is problematic. Hopefully, if promising results come in, more objective research can advance it for everyone’s benefit.

--

The world and workforce need wisdom. Why don’t universities teach it?

Universities claim to prepare students for the world. How many actually do it?

Photo: Take A Pix Media / Getty Images
Sponsored by Charles Koch Foundation
  • Many university mission statements do not live up to their promise, writes Ben Nelson, founder of Minerva, a university designed to develop intellect over content memorization.
  • The core competencies that students need for success—critical thinking, communication, problem solving, and cross-cultural understanding, for example—should be intentionally taught, not left to chance.
  • These competencies can be summed up with one word: wisdom. True wisdom is the ability to apply one's knowledge appropriately when faced with novel situations.
Keep reading Show less

What the world will look like in the year 250,002,018

This is what the world will look like, 250 million years from now

On Pangaea Proxima, Lagos will be north of New York, and Cape Town close to Mexico City
Surprising Science

To us humans, the shape and location of oceans and continents seems fixed. But that's only because our lives are so short.

Keep reading Show less

Six-month-olds recognize (and like) when they’re being imitated

A new study may help us better understand how children build social cognition through caregiver interaction.

Personal Growth
  • Scientists speculate imitation helps develop social cognition in babies.
  • A new study out of Lund University shows that six-month-olds look and smile more at imitating adults.
  • Researchers hope the data will spur future studies to discover what role caregiver imitation plays in social cognition development.
  • Keep reading Show less

    New study connects cardiovascular exercise with improved memory

    Researchers at UT Southwestern noted a 47 percent increase in blood flow to regions associated with memory.

    An elderly man runs during his morning exercises at the promenade on the Bund along the Huangpu Rive the Bund in Shanghai on May 18, 2017.

    Photo: Johannes Eisele/AFP via Getty Images
    Surprising Science
    • Researchers at UT Southwestern observed a stark improvement in memory after cardiovascular exercise.
    • The year-long study included 30 seniors who all had some form of memory impairment.
    • The group of seniors that only stretched for a year did not fair as well in memory tests.
    Keep reading Show less
    Scroll down to load more…