Understanding Addiction: Why I Only Need Two Drinks and You Need Eight
If your mother was stressed during pregnancy, then you have a higher probability of being an addict when you grow up.
David J. Linden is a Professor in the Department of Neuroscience at the Johns Hopkins University School of Medicine. His laboratory has worked for many years on the cellular substrates of memory storage in the brain and a few other topics. He has a longstanding interest in scientific communication and serves as the Chief Editor of the Journal of Neurophysiology. He lives in Baltimore, Maryland with his two children.
David is the author of The Accidental Mind: How Brain Evolution Has Given Us Love, Memory, Dreams and God and most recently, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good.
The brain’s pleasure circuit is critically dependent upon a neurotransmitter called Dopamine. And so if you carry a genetic variance that turns down the Dopamine function within your pleasure circuit, Dopamine receptors or enzymes that process or package Dopamine for release at the synapses, which are the connections between neurons, then your pleasure will be blunted.
So for example, I go into a bar, I drink two drinks, I feel a little tipsy, I feel good, I hand out with my friends, I leave, I go home. Someone who inherits a genetic variant where their Dopamine signaling is turned down, they go into the bar, they’ve got to have eight drinks to feel the same pleasure that I could get with two.
So it really seems across addictions, not just for alcohol and drugs, but for gambling and sex and food that addicts are attempting to seek the same set point of pleasure through overindulgence that so-called normals can get with more moderate consumption.
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