Which Genes Cause Disease?

New genomic analyses suggest that the most common genetic variants in the human genome aren't the ones most likely causing disease, genetic experts at Duke University Medical Center report.

Dr. David Goldstein, director of the Duke Center for Human Genome Variation, said: "'The more common a variant is, the less likely it is to be found in a functional region of the genome. Scientists have reported this observation before, but this study is the most comprehensive effort to date using annotations of the functional regions of the human genome and fully sequenced genomes.' ... He also said he was surprised by the notable consistency of the finding. 'It's not just that the most rare variants are different from the most common, it's that at every increase in frequency, a variant is less and less likely to be found in a functional region of the DNA,' Goldstein said."

Big Think Edge
  • The meaning of the word 'confidence' seems obvious. But it's not the same as self-esteem.
  • Confidence isn't just a feeling on your inside. It comes from taking action in the world.
  • Join Big Think Edge today and learn how to achieve more confidence when and where it really matters.
Videos
  • Bad outcomes get criticized as evidence of bad decisions, but that's not necessarily so.
  • Here, poker pro Annie Duke desribes a simple thought experiment that separates decisions from outcomes.
  • It is quite possible to make a very good decision that, due to external factors, results in a bad outcome.


Decide to Play Great Poker: A Strategy Guide to No-Limit Texas Hold '’Em

www.amazon.com

Decide to Play Great Poker: A Strategy Guide to No-Limit Texas Hold '’Em [Annie Duke, John Vorhaus] on Amazon.com. *FREE* shipping on qualifying offers. Ask the great poker players how they'd play a hand and the answer is always, It depends. That answer can be infuriating. But guess what? It really does depend. The key to becoming a great poker player is in knowing exactly what it depends on. At last there's a book that gives you that answer. Poker is a game of so many variables: table position

Racial purity is 'scientifically meaningless,' say 8,000 geneticists

American geneticists take a stand against the misuse of their science by racists.

Milk chugging white supremacists.
Politics & Current Affairs
  • The largest society of geneticists decries the distortion of ideas by racists.
  • Science does not support the concept of race.
  • Race is a social construct, explain the scientists.
Keep reading Show less

To boost your self-esteem, write about chapters of your life

If you're lacking confidence and feel like you could benefit from an ego boost, try writing your life story.

Personal Growth

In truth, so much of what happens to us in life is random – we are pawns at the mercy of Lady Luck. To take ownership of our experiences and exert a feeling of control over our future, we tell stories about ourselves that weave meaning and continuity into our personal identity.

Keep reading Show less