Sleep-Disrupted Mice Get Fat & Dumb
Artificially separated from a natural cycle of light and dark, the bodies and brains of mice go haywire in ways that may mimic the human effects of circadian disruption.
McEwen’s team turned lab lights on and off to create 20-hour days for mice, while a control group was kept on a regular 24 hour schedule. Within six weeks, the disrupted group started to gain weight, despite eating the same diet as controls. They grew obese, and had altered levels of insulin and leptin, two key metabolic hormones. Effects extended to their brains. In the prelimbic prefrontal cortex, a region important to emotional control and cognitive flexibility, neurons shrank and were arranged in less complex ways. The mice had trouble learning to navigate mazes, and were spooked by new environments. The researchers hope their model of disruption will be used for further investigation of circadian disruption.
Upstreamism advocate Rishi Manchanda calls us to understand health not as a "personal responsibility" but a "common good."
- Upstreamism tasks health care professionals to combat unhealthy social and cultural influences that exist outside — or upstream — of medical facilities.
- Patients from low-income neighborhoods are most at risk of negative health impacts.
- Thankfully, health care professionals are not alone. Upstreamism is increasingly part of our cultural consciousness.
It marks a major shift in the government's battle against the opioid crisis.
- The nation's sixth-largest drug distributor is facing criminal charges related to failing to report suspicious drug orders, among other things.
- It marks the first time a drug company has faced criminal charges for distributing opioids.
- Since 1997, nearly 222,000 Americans have died from prescription opioids, partly thanks to unethical doctors who abuse the system.
A new study shows that some men's reaction to sex is not what you'd expect, resulting in a condition previously observed in women.
The real Game of Thrones might be who best leverages the hit HBO show to shape political narratives.
- Sen. Elizabeth Warren argues that Game of Thrones is primarily about women in her review of the wildly popular HBO show.
- Warren also touches on other parallels between the show and our modern world, such as inequality, political favoritism of the elite, and the dire impact of different leadership styles on the lives of the people.
- Her review serves as another example of using Game of Thrones as a political analogy and a tool for framing political narratives.
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