Gene Therapy to Treat Depression

"Researchers find they can alleviate depression in mice by boosting a protein in one part of the brain." Technology Review on how gene therapy could be used in humans.

"For decades, medications for depression have acted pretty much the same way—by manipulating levels of serotonin and other chemical messengers in the brain. New drugs have offered only modest changes from the old ones. Now a team of researchers, led by Michael Kaplitt, an associate professor at Weill Cornell Medical College, has proposed a different way to attack depression: by using gene therapy to boost levels of a protein called p11 in an area of the brain called the nucleus accumbens. 'We do believe that the deficiency of this gene in this area of the brain may be one of the underlying root causes of depression, and that addressing that could help improve symptoms,' says Kaplitt."

'Upstreamism': Your zip code affects your health as much as genetics

Upstreamism advocate Rishi Manchanda calls us to understand health not as a "personal responsibility" but a "common good."

Sponsored by Northwell Health
  • Upstreamism tasks health care professionals to combat unhealthy social and cultural influences that exist outside — or upstream — of medical facilities.
  • Patients from low-income neighborhoods are most at risk of negative health impacts.
  • Thankfully, health care professionals are not alone. Upstreamism is increasingly part of our cultural consciousness.
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Big Think Edge
  • Economist Sylvia Ann Hewlett breaks down what qualities will inspire others to believe in you.
  • Here's how 300 leaders and 4,000 mid-level managers described someone with executive presence.
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Is there an optimal time of day to exercise?

Two new studies say yes. Unfortunately, each claims a different time.

Bronx, N.Y.: NYPD officer Julissa Camacho works out at the 44th precinct gym in the Bronx, New York on April 3, 2019. (Photo by Alejandra Villa Loarca/Newsday via Getty Images)
Surprising Science
  • Research at the Weizmann Institute of Sciences declares evening to be the best time for an exercise session.
  • Not so fast, says a new study at UC Irvine, which replies that late morning is the optimal workout time.
  • Both studies involved mice on treadmills and measured different markers to produce their results.
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In U.S. first, drug company faces criminal charges for distributing opioids

It marks a major shift in the government's battle against the opioid crisis.

George Frey/Bloomberg via Getty Images
Politics & Current Affairs
  • The nation's sixth-largest drug distributor is facing criminal charges related to failing to report suspicious drug orders, among other things.
  • It marks the first time a drug company has faced criminal charges for distributing opioids.
  • Since 1997, nearly 222,000 Americans have died from prescription opioids, partly thanks to unethical doctors who abuse the system.
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