How an HIV Vaccine Could Be the Cure
Researchers at Johns Hopkins School of Medicine have found that an HIV vaccine could work in conjunction with antiretroviral therapies, prepping the immune system to eliminate HIV-1 viruses.
What's the Latest Development?
Researchers at Johns Hopkins have found that a vaccine could work in conjunction with antiretroviral medications to eliminate HIV from patients' bodies. The virus enters a dormant or 'latent' state with antiretroviral treatment but quickly reactivates when the treatments are stopped. In a recent experiment, Dr. Robert F. Siliciano of Johns Hopkins found that a vaccine which boosts the immune response of host T-cells just before antiretroviral treatments are stopped helps the body to eliminate HIV once it becomes reactivated.
What's the Big Idea?
Antiretroviral therapies, which work by making HIV cells dormant in the body, cannot eliminate the disease, meaning patients must commit to the therapy all their life. This raises concerns over non-compliance and the treatment's financial burden on patients, particularly among those in poor regions of the world where the disease is more prevalent to begin with. Life-long antiretroviral treatment also raises the risk that the HIV-1 virus will mutate and become resistant to treatment, says Siliciano. For this reason, a vaccine may prove essential.
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Step inside the unlikely friendship of a former ACLU president and an ultra-conservative Supreme Court Justice.
- Former president of the ACLU Nadine Strossen and Supreme Court Justice Antonin Scalia were unlikely friends. They debated each other at events all over the world, and because of that developed a deep and rewarding friendship – despite their immense differences.
- Scalia, a famous conservative, was invited to circles that were not his "home territory", such as the ACLU, to debate his views. Here, Strossen expresses her gratitude and respect for his commitment to the exchange of ideas.
- "It's really sad that people seem to think that if you disagree with somebody on some issues you can't be mutually respectful, you can't enjoy each other's company, you can't learn from each other and grow in yourself," says Strossen.
- The opinions expressed in this video do not necessarily reflect the views of the Charles Koch Foundation, which encourages the expression of diverse viewpoints within a culture of civil discourse and mutual respect.
Learn how to redesign your job for maximum reward.
- Broaching the question "What is my purpose?" is daunting – it's a grandiose idea, but research can make it a little more approachable if work is where you find your meaning. It turns out you can redesign your job to have maximum purpose.
- There are 3 ways people find meaning at work, what Aaron Hurst calls the three elevations of impact. About a third of the population finds meaning at an individual level, from seeing the direct impact of their work on other people. Another third of people find their purpose at an organizational level. And the last third of people find meaning at a social level.
- "What's interesting about these three elevations of impact is they enable us to find meaning in any job if we approach it the right way. And it shows how accessible purpose can be when we take responsibility for it in our work," says Hurst.
Erik Verlinde has been compared to Einstein for completely rethinking the nature of gravity.
- The Dutch physicist Erik Verlinde's hypothesis describes gravity as an "emergent" force not fundamental.
- The scientist thinks his ideas describe the universe better than existing models, without resorting to "dark matter".
- While some question his previous papers, Verlinde is reworking his ideas as a full-fledged theory.
TuSimple, an autonomous trucking company, has also engaged in test programs with the United States Postal Service and Amazon.
PAUL RATJE / Contributor
- This week, UPS announced that it's working with autonomous trucking startup TuSimple on a pilot project to deliver cargo in Arizona using self-driving trucks.
- UPS has also acquired a minority stake in TuSimple.
- TuSimple hopes its trucks will be fully autonomous — without a human driver — by late 2020, though regulatory questions remain.