Test Can Predict Alzheimer's 18 Years Ahead of Onset
Researchers find the symptoms of Alzheimer's disease may manifest substantially earlier than previously thought.
Natalie has been writing professionally for about 6 years. After graduating from Ithaca College with a degree in Feature Writing, she snagged a job at PCMag.com where she had the opportunity to review all the latest consumer gadgets. Since then she has become a writer for hire, freelancing for various websites. In her spare time, you may find her riding her motorcycle, reading YA novels, hiking, or playing video games. Follow her on Twitter: @nat_schumaker
Alzheimer's disease is something most of us would rather not think about — our memories and our identity slowly slipping as we age. But recent breakthroughs have shown significant hope, making diagnosis and early detection possible in the future. One past study showed a causal link between poor sleep and the disease later on in life. A new study suggests that errors in memory and thinking tests could be a red flag for Alzheimer's up to 18 years in advance.
Kumar B. Rajan, from the Rush University Medical Center in Chicago, led the study, which has been published in the journal Neurology.
He said in a press release that his findings suggest:
"The changes in thinking and memory that precede obvious symptoms of Alzheimer's disease begin decades before. While we cannot currently detect such changes in individuals at risk, we were able to observe them among a group of individuals who eventually developed dementia due to Alzheimer's."
The study consisted of 2,125 participants with an average age of 73 — all without Alzheimer's disease when the study began. For the next 18 years, every three years, the participants were given an exam, which tested their memory and thinking. The researcher reported that a total of “442 (21 percent) developed clinical [Alzheimer's disease] dementia over 18 years of follow-up.”
Over the course of the study, the researcher found “[p]erformance on individual cognitive tests of episodic memory, executive function, and global cognition ... significantly predicted the development of [Alzheimer's] dementia, with associations exhibiting a similar trend over 18 years.” Their study shows substantial evidence that the symptoms of Alzheimer's disease may manifest substantially earlier than previously thought.
"A general current concept is that in development of Alzheimer's disease, certain physical and biologic changes precede memory and thinking impairment. If this is so, then these underlying processes may have a very long duration. Efforts to successfully prevent the disease may well require a better understanding of these processes near middle age."
Read more about the study at Science Daily.
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Why self-control makes your life better, and how to get more of it.
(Photo by Geem Drake/SOPA Images/LightRocket via Getty Images)
- Research demonstrates that people with higher levels of self-control are happier over both the short and long run.
- Higher levels of self-control are correlated with educational, occupational, and social success.
- It was found that the people with the greatest levels of self-control avoid temptation rather than resist it at every turn.
Ready your Schrödinger's Cat Jokes.
- For a time, quantum computing was more theory than fact.
- That's starting to change.
- New quantum computer designs look like they might be scalable.
Quantum computing has existed in theory since the 1980's. It's slowly making its way into fact, the latest of which can be seen in a paper published in Nature called, "Deterministic teleportation of a quantum gate between two logical qubits."
To ensure that we're all familiar with a few basic terms: in electronics, a 'logic gate' is something that takes in one or more than one binary inputs and produces a single binary output. To put it in reductive terms: if you produce information that goes into a chip in your computer as a '0,' the logic gate is what sends it out the other side as a '1.'
A quantum gate means that the '1' in question here can — roughly speaking — go back through the gate and become a '0' once again. But that's not quite the whole of it.
A qubit is a single unit of quantum information. To continue with our simple analogy: you don't have to think about computers producing a string of information that is either a zero or a one. A quantum computer can do both, simultaneously. But that can only happen if you build a functional quantum gate.
That's why the results of the study from the folks at The Yale Quantum Institute saying that they were able to create a quantum gate with a "process fidelity" of 79% is so striking. It could very well spell the beginning of the pathway towards realistic quantum computing.
The team went about doing this through using a superconducting microwave cavity to create a data qubit — that is, they used a device that operates a bit like a organ pipe or a music box but for microwave frequencies. They paired that data qubit with a transmon — that is, a superconducting qubit that isn't as sensitive to quantum noise as it otherwise could be, which is a good thing, because noise can destroy information stored in a quantum state. The two are then connected through a process called a 'quantum bus.'
That process translates into a quantum property being able to be sent from one location to the other without any interaction between the two through something called a teleported CNOT gate, which is the 'official' name for a quantum gate. Single qubits made the leap from one side of the gate to the other with a high degree of accuracy.
Above: encoded qubits and 'CNOT Truth table,' i.e., the read-out.
The team then entangled these bits of information as a way of further proving that they were literally transporting the qubit from one place to somewhere else. They then analyzed the space between the quantum points to determine that something that doesn't follow the classical definition of physics occurred.
They conclude by noting that "... the teleported gate … uses relatively modest elements, all of which are part of the standard toolbox for quantum computation in general. Therefore ... progress to improve any of the elements will directly increase gate performance."
In other words: they did something simple and did it well. And that the only forward here is up. And down. At the same time.
These modern-day hermits can sometimes spend decades without ever leaving their apartments.
- A hikikomori is a type of person in Japan who locks themselves away in their bedrooms, sometimes for years.
- This is a relatively new phenomenon in Japan, likely due to rigid social customs and high expectations for academic and business success.
- Many believe hikikomori to be a result of how Japan interprets and handles mental health issues.
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