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Scientists modify chickens to lay cancer-fighting eggs

Image: Biswarup Ganguly
  • The eggs contain an antiviral protein called human interferon beta.
  • This protein is known to combat some forms of cancer and other conditions.
  • The unusual technique could one day provide cheaper and more effective treatments.

Scientists in Japan have genetically modified chickens to lay eggs containing an extremely valuable protein that helps treat cancer, hepatitis and multiple sclerosis in humans.

The cost of one of these so-called 'golden eggs' is estimated to be between $535,995 and $2.6 million. However, researchers described their work as still being in the early steps and on the road toward cheaper cancer treatment.

"This is a result that we hope leads to the development of cheap drugs," Hironobu Hojo, professor at Osaka University, told The Japan News. "In the future, it will be necessary to closely examine the characteristics of the agents contained in the eggs and determine their safety as pharmaceutical products."

The researchers, working out of Japan's Biomedical Research Institute at the National Institute of Advanced Industrial Science and Technology, recently described their findings in a paper published in Nature.

The 'golden eggs' contain high amounts of human interferon beta, an antiviral protein thought to combat some forms of cancer and hepatitis, and to slow the progression of multiple sclerosis.

How it works

To get hens to lay the valuable eggs, the team used genome-editing technology to modify cells from cockerel embryos so that the animal's protein-producing DNA would go on to produce human interferon beta in eggs instead of normal egg whites. These cells were then reinserted into the embryos and the cockerels later mated with hens.

After two generations, hens were laying eggs with visibly cloudier whites that contained human interferon beta.

Image: Oishi et al.

The researchers are working with Cosmo Bio, a Japanese reagent maker, to potentially produce the drug for the commercial market.

"For interferon-beta protein, we have about 20 hens in-house," Mika Kitahara, a spokesperson for Cosmo Bio, told The Telegraph. "So far our hens produce the eggs constantly, just like normal hens."

Kitahara noted that the process doesn't seem to harm the chickens. "These hens can produce eggs constantly, so we can obtain recombinant proteins in large amounts and with stability," she said. "In addition, this system doesn't involve killing hens."

Hulu's original movie "Palm Springs" is the comedy we needed this summer

Andy Samberg and Cristin Milioti get stuck in an infinite wedding time loop.

Gear
  • Two wedding guests discover they're trapped in an infinite time loop, waking up in Palm Springs over and over and over.
  • As the reality of their situation sets in, Nyles and Sarah decide to enjoy the repetitive awakenings.
  • The film is perfectly timed for a world sheltering at home during a pandemic.
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Two MIT students just solved Richard Feynman’s famed physics puzzle

Richard Feynman once asked a silly question. Two MIT students just answered it.

Surprising Science

Here's a fun experiment to try. Go to your pantry and see if you have a box of spaghetti. If you do, take out a noodle. Grab both ends of it and bend it until it breaks in half. How many pieces did it break into? If you got two large pieces and at least one small piece you're not alone.

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Our ‘little brain’ turns out to be pretty big

The multifaceted cerebellum is large — it's just tightly folded.

Image source: Sereno, et al
Mind & Brain
  • A powerful MRI combined with modeling software results in a totally new view of the human cerebellum.
  • The so-called 'little brain' is nearly 80% the size of the cerebral cortex when it's unfolded.
  • This part of the brain is associated with a lot of things, and a new virtual map is suitably chaotic and complex.

Just under our brain's cortex and close to our brain stem sits the cerebellum, also known as the "little brain." It's an organ many animals have, and we're still learning what it does in humans. It's long been thought to be involved in sensory input and motor control, but recent studies suggests it also plays a role in a lot of other things, including emotion, thought, and pain. After all, about half of the brain's neurons reside there. But it's so small. Except it's not, according to a new study from San Diego State University (SDSU) published in PNAS (Proceedings of the National Academy of Sciences).

A neural crêpe

A new imaging study led by psychology professor and cognitive neuroscientist Martin Sereno of the SDSU MRI Imaging Center reveals that the cerebellum is actually an intricately folded organ that has a surface area equal in size to 78 percent of the cerebral cortex. Sereno, a pioneer in MRI brain imaging, collaborated with other experts from the U.K., Canada, and the Netherlands.

So what does it look like? Unfolded, the cerebellum is reminiscent of a crêpe, according to Sereno, about four inches wide and three feet long.

The team didn't physically unfold a cerebellum in their research. Instead, they worked with brain scans from a 9.4 Tesla MRI machine, and virtually unfolded and mapped the organ. Custom software was developed for the project, based on the open-source FreeSurfer app developed by Sereno and others. Their model allowed the scientists to unpack the virtual cerebellum down to each individual fold, or "folia."

Study's cross-sections of a folded cerebellum

Image source: Sereno, et al.

A complicated map

Sereno tells SDSU NewsCenter that "Until now we only had crude models of what it looked like. We now have a complete map or surface representation of the cerebellum, much like cities, counties, and states."

That map is a bit surprising, too, in that regions associated with different functions are scattered across the organ in peculiar ways, unlike the cortex where it's all pretty orderly. "You get a little chunk of the lip, next to a chunk of the shoulder or face, like jumbled puzzle pieces," says Sereno. This may have to do with the fact that when the cerebellum is folded, its elements line up differently than they do when the organ is unfolded.

It seems the folded structure of the cerebellum is a configuration that facilitates access to information coming from places all over the body. Sereno says, "Now that we have the first high resolution base map of the human cerebellum, there are many possibilities for researchers to start filling in what is certain to be a complex quilt of inputs, from many different parts of the cerebral cortex in more detail than ever before."

This makes sense if the cerebellum is involved in highly complex, advanced cognitive functions, such as handling language or performing abstract reasoning as scientists suspect. "When you think of the cognition required to write a scientific paper or explain a concept," says Sereno, "you have to pull in information from many different sources. And that's just how the cerebellum is set up."

Bigger and bigger

The study also suggests that the large size of their virtual human cerebellum is likely to be related to the sheer number of tasks with which the organ is involved in the complex human brain. The macaque cerebellum that the team analyzed, for example, amounts to just 30 percent the size of the animal's cortex.

"The fact that [the cerebellum] has such a large surface area speaks to the evolution of distinctively human behaviors and cognition," says Sereno. "It has expanded so much that the folding patterns are very complex."

As the study says, "Rather than coordinating sensory signals to execute expert physical movements, parts of the cerebellum may have been extended in humans to help coordinate fictive 'conceptual movements,' such as rapidly mentally rearranging a movement plan — or, in the fullness of time, perhaps even a mathematical equation."

Sereno concludes, "The 'little brain' is quite the jack of all trades. Mapping the cerebellum will be an interesting new frontier for the next decade."

Economists show how welfare programs can turn a "profit"

What happens if we consider welfare programs as investments?

A homeless man faces Wall Street

Spencer Platt/Getty Images
Politics & Current Affairs
  • A recently published study suggests that some welfare programs more than pay for themselves.
  • It is one of the first major reviews of welfare programs to measure so many by a single metric.
  • The findings will likely inform future welfare reform and encourage debate on how to grade success.
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Unhappy at work? How to find meaning and maintain your mental health

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