Write in style for life with this 100% inkless wooden stylus
Two famous Italian design companies joined forces to create this masterpiece.
- Styluses date back to ancient Mesopotamia and are considered the original writing instruments.
- With no lead, graphite, or ink cartridges, this stylus will last a lifetime without replacement parts.
- Two top Italian design companies worked together to create this unique stylus.
Ancient Mesopotamians used styluses to write in cuneiform. Egyptians used reed styluses in order to write hieroglyphs. Western Europeans employed styluses until the late Middle Ages to jot down text. And they're still used in Mexico in pottery design.
Writing still matters, even in a technological age. Research has shown that writing your notes by hand helps you retain information better than typing. That means your memory stays sharper as you age. You remember ideas and facts more efficiently thanks to the motor coordination needed in writing. And styluses offer a unique opportunity to connect with the original form of writing instruments. You can feel that connection for yourself with the Forever Pininfarina Cambiano Inkless Pen—a beautifully crafted stylus that produces elegant text with no ink, lead, or graphite.
This stylus is the result of a partnership between NAPKIN®, an Italian company with significant design experience, and Pininfarina, a famed Italian design company founded in 1930. Crafted with an aluminum shell and an Ethegraph (patented metal alloy) tip, you're guaranteed a lifetime of gorgeous penmanship with this masterpiece.
The Forever Pininfarina Cambiano is also beautiful. You'll feel a sense of elegance when picking it up from your desk to take notes or bring life to your thoughts. There's something to be said for such simple pleasures.
Connect with the original form of penmanship with this luxe, everlasting pen. The Forever Pininfarina Cambiano Inkless Pen is on sale for just $64.99, nearly half off of the original price.
The microbes that eventually produced the planet's oxygen had to breathe something, after all.
- We owe the Earth's oxygen to ancient microbes that photosynthesized and released it into the world's oceans.
- A long-standing question has been "before oxygen, what did they breathe?"
- The discovery of microbes living in a hostile early-Earth-like environment may provide the answer.
Unassuming but remarkable microbial mats<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ0NzE3Ny9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzMjk0MzE4Nn0.FhrDr5RTfRIBdf5uhnmzSPNYz-CwNiPbVYgam5eNaoY/img.jpg?width=980" id="d5e1c" class="rm-shortcode" data-rm-shortcode-id="c2e5e1b019d0bb1987ee730f91b550cc" data-rm-shortcode-name="rebelmouse-image" />
Credit: Razzu Engen/Flickr<p> Photosynthesis chiefly requires sunlight, water, and CO<sup>2</sup>. The CO<sup>2</sup> gets broken down into carbon and oxygen — the plant uses some of this oxygen and releases the rest. Without CO<sup>2</sup>'s oxygen molecules, though, how did this work? </p><p> There are known microbial mats today that live in oxygen-free environments, but they're not thought to be sufficiently like their ancestors to explain ancient photosynthesis in an oxygen-free environment. </p><p> There have been a few oxygen stand-ins proposed. Photosynthesis can work with iron molecules, but fossil-record evidence doesn't support that idea. Hydrogen and sulphur have also been proposed, though evidence for them is also lacking. </p><p> The spotlight began to shift to arsenic in the first decade of the millennium when arsenic-breathing microbial mats were discovered in two hypersaline California lakes, <a href="https://science.sciencemag.org/content/308/5726/1305.abstract" target="_blank">Searles Lake</a> and <a href="https://www.discovermagazine.com/planet-earth/mono-lake-bacteria-build-their-dna-using-arsenic-and-no-this-isnt-about-aliens" target="_blank" rel="noopener noreferrer">Mono Lake</a>. In 2014, Visscher and colleagues <a href="https://www.nature.com/articles/ngeo2276" target="_blank">unearthed indications</a> of arsenic-based photosynthesis, or ""arsenotrophic," microbial mats deep in the fossil record of the Tumbiana Formation of Western Australia. </p><p> Still, given the ever-shifting geology of the planets, the fractured ancient fossil record makes definitive study of ancient arsenotrophic photosynthesis difficult. The fossil record can't identify the role of the arsenic it reveals: was it involved in photosynthesis or just a toxic chemical that happened to be there? </p><p>Then, last year, arsenic-breathing microorganisms <a href="https://www.washington.edu/news/2019/05/01/arsenic-breathing-life-discovered-in-the-tropical-pacific-ocean/" target="_blank" rel="noopener noreferrer">were discovered</a> in the Pacific Ocean. A sulphur bacterium, <em>Ectothiorhodospira sp.</em> was also recently found to be metablozing arsenic into <a href="https://en.wikipedia.org/wiki/Arsenite" target="_blank">arsenite</a> in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064118/" target="_blank" rel="noopener noreferrer">Big Soda Lake</a> in Nevada. </p>
An ancient Earth environment, today<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ0NzIxMC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY1OTQwOTYyN30.v96ZRXpIAf4yzDwcvXzVV3Fa4qULtUMxanXguPHD2wI/img.jpg?width=980" id="9eec4" class="rm-shortcode" data-rm-shortcode-id="a23585c057ee50ed500b96125e4a6b05" data-rm-shortcode-name="rebelmouse-image" />
a Map of Northern Chile; b Detail of frame showing Laguna La Brava in the southern Atacama; c The channel showing the mats in purple; d Hand sample, cross-section; e Microscopic image of bacteria.
Credit: Visscher, et al./communications earth & environment<p>The study reports on Visscher's discovery of a living microbial mat thriving in an arsenic environment in Laguna La Brava in the Atacama Desert in Chile. "We started working in Chile," Visscher tells <a href="https://today.uconn.edu/2020/09/without-oxygen-earths-early-microbes-relied-arsenic-sustain-life/" target="_blank"><em>UConn Today</em></a>, "where I found a blood-red river. The red sediments are made up by <a href="https://en.wikipedia.org/wiki/Anoxygenic_photosynthesis" target="_blank">anoxogenic</a> photosynthetic bacteria. The water is very high in arsenic as well. The water that flows over the mats contains hydrogen sulfide that is volcanic in origin and it flows very rapidly over these mats. There is absolutely no oxygen."</p><p>The mats have not previously been studied, and the conditions in which they live are tantalizingly similar to those of early Earth. It's a high-altitude, permanently oxygen-free state with extreme temperature swings and lots of UV exposure. </p><p>The mats that somewhat resemble Nevada's purple <em>Ectothiorhodospira sp.</em> are going about their business of making carbonate deposits, forming new stromatolites. Most excitingly, those deposits contain evidence that the mats are metabolizing arsenic. The rushing waters surrounding the mats are also rich in hydrogen sulphide and arsenic.</p><p>Says Visscher, "I have been working with microbial mats for about 35 years or so. This is the only system on Earth where I could find a microbial mat that worked absolutely in the absence of oxygen."</p><p>Not that Earth is the only place where this could happen. Visscher notes that the equipment they used for studying the Laguna La Brava mats is not unlike the system aboard the Mars Perseverance Rover. He says, "In looking for evidence of life on Mars, they will be looking at iron, and probably they should be looking at arsenic also."</p>
Techshot's 3D BioFabrication Facility successfully printed human heart tissue aboard the International Space Station.
All that's fit to bioprint<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ0MTc4OS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NjUyMTkxN30.c02tUlYJLxdekTGR5ExOagL2Sh-5rmWN6pYkqger920/img.jpg?width=1245&coordinates=0%2C210%2C0%2C2&height=700" id="c20c0" class="rm-shortcode" data-rm-shortcode-id="a6a286e57a8ba31f1fd815c03bfd080d" data-rm-shortcode-name="rebelmouse-image" />
Dr. Eugene Boland, Techshot's chief scientist, presents the 3D BioFabrication Facility at NASA's Kennedy Space Center, Florida
A heart from your new BFF<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="1fa24e6ada521bcdac46de275c37f2da"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/p_hauPqouH8?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>In partnership with <a href="https://www.nscrypt.com/about-us/" target="_blank">nScrypt</a>, Techshot developed the BFF to manufacture human tissue in space. In July 2019, they launched the bioprinter aboard the SpaceX CRS-18 cargo mission to be delivered to the International Space Station. There, it was loaded up with nerve, muscle, and vascular bioinks. As the BFF pinned the cells together in a culturing cassette, generating layers several times thinner than a human hair, the microgravity environment ensured the low-viscosity structure kept together. That's courtesy of the same surface tension property that allows for those <a href="https://www.youtube.com/watch?v=H_qPWZbxFl8" target="_blank">moving water spheres astronauts love to play with</a>.</p><p>"So, now you can have a vascular cell where you want a blood vessel to be, the nerve cell where you want the nerve to pass through, and muscle cells where you need a muscle bundle to be," Boland said. "All of those will stay where you put them in three-dimensions and then grow and mature where you want them."</p><p>A non-cellular ink was added to the mix to provide a bit of framework and prevent cells from sliding around during the printing process. But because Earth's gravity had less pull, this framework didn't need to be as ridged as terrestrial scaffolding. This non-cellular ink was water-soluble, meaning it could be washed away after the printing was complete. The end result, a more natural fabrication of human tissue.</p><p>Once 25 percent of the cells needed for the mature tissue were in place, the cell-culturing cassette was moved to another payload, the Advanced Space Experiment Processor (ADSEP). There, the cells lived and grew as they would naturally. Fully differentiated cells signaled to the adult stems cells that they should be heart cells. The stem cells grew and multiplied, supported by the nutrients provided in the ink. A few weeks later and the cassette was home to human heart tissue.</p><p>This January, <a href="https://www.prnewswire.com/news-releases/success-3d-bioprinter-in-space-prints-with-human-heart-cells-300982759.html" target="_blank">Techshot announced</a> the BFF had cultured successful test prints aboard the ISS. These heart prints measured 30 mm long by 20 mm wide by 12.6mm high. In a follow-up experiment, the BFF also manufactured <a href="https://techshot.com/techshot-successfully-completes-knee-cartilage-test-prints-in-space/" target="_blank" rel="noopener noreferrer">test prints of a partial human knee meniscus</a>, the soft cartilage that acts as a shock absorber between your shinbone and thighbone.</p>
The future of medicine is in space?<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ0MTc5MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY2MjQwODUxOH0.VAg1FIZkGz_IOCaGUAHxylX1h44qA2-tk-9odXPoLT0/img.jpg?width=1245&coordinates=0%2C118%2C0%2C94&height=700" id="2176b" class="rm-shortcode" data-rm-shortcode-id="932d3caca0897797883d941a6255885e" data-rm-shortcode-name="rebelmouse-image" />
NASA Astronaut Jessica Meir prepares Techshot's cell-culturing cassettes for their return trip to Earth.
Crows have their own version of the human cerebral cortex.
Action-packed pallia<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ0NjkyOS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyMjg5MDExM30.Od6d_eg9TvI7qbCLHvyDbxAX4cODF3mDtD0mwjD9KyM/img.jpg?width=980" id="6ddd1" class="rm-shortcode" data-rm-shortcode-id="ac499ad788511254fe0355e497ad8e39" data-rm-shortcode-name="rebelmouse-image" />
Credit: Amaranth Tade/Unsplash<p>It's long been assumed that higher intellectual functioning is strictly the product of a layered cerebral cortex. But bird brains are different, and the authors of the study found crows' unlayered but neuron-dense <a href="https://en.wikipedia.org/wiki/Pallium_(neuroanatomy)" target="_blank">pallium</a> may play a similar role for the avians. Supporting this possibility, <a href="https://science.sciencemag.org/cgi/doi/10.1126/science.abc5534" target="_blank">another study</a> published last week in <em>Science</em> finds that the neuroanatomy of pigeons and barn owls may also support higher intelligence.</p><p>"It has been a good week for bird brains!" crow expert John Marzluff of the University of Washington <a href="https://www.statnews.com/2020/09/24/crows-possess-higher-intelligence-long-thought-primarily-human/?utm_content=buffer87cd6&utm_medium=social&utm_source=twitter&utm_campaign=twitter_organic" target="_blank">tells Stat</a>. (He was not involved in either study.)</p><p>Corvids are known to be as mentally capable as monkeys and great apes. However, bird neurons are so much smaller that their palliums actually contain many more of them than would be found in an equivalent-sized primate cortex. This may constitute a clue regarding their expansive mental capabilities.</p><p>In any event, there appears to be a general correspondence between the number of neurons and animal has in its pallium and its intelligence, says <a href="http://www.suzanaherculanohouzel.com" target="_blank" rel="noopener noreferrer">Suzana Herculano-Houzel</a> in her <a href="https://science.sciencemag.org/content/369/6511/1567" target="_blank">commentary</a> on both new studies for <em>Science</em>. Humans, she says, sit "satisfyingly" atop this comparative chart, having even more neurons there than elephants, despite our much smaller body size. It's estimated that crow brains have about 1.5 billion neurons.</p>
Fun with Ozzie and Glenn<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ0Njk2MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYxMzY4Njc2MX0.ZgpsPMCK6qOj2o0kErvVPjdua1EnMCIwCuHHGrb3LiY/img.jpg?width=980" id="acbeb" class="rm-shortcode" data-rm-shortcode-id="4061cce4f4b679e5b0836a04ec6bff49" data-rm-shortcode-name="rebelmouse-image" />
Ozzie and Glenn (not pictured)
Credit: narubono/Unsplash<p>The kind of higher intelligence crows exhibited in the new research is similar to the way we solve problems. We catalog the relevant knowledge we possess and then explore different combinations of what we know to arrive at an action or solution.</p><p>The researchers, led by neurobiologist <a href="https://homepages.uni-tuebingen.de/andreas.nieder/" target="_blank">Andreas Nieder</a> of the University of Tübingen in Germany, trained two carrion crows (<em>Corvus corone</em>), Ozzie and Glenn.</p><p>The crows were trained to watch for a flash — which didn't always appear — and then peck at a red or blue target to register whether or not a flash of light was seen. Ozzie and Glenn were also taught to understand a changing "rule key" that specified whether red or blue signified the presence of a flash with the other color signifying that no flash occurred.</p><p>In each round of a test, after a flash did or didn't appear, the crows were presented a rule key describing the current meaning of the red and blue targets, after which they pecked their response.</p><p>This sequence prevented the crows from simply rehearsing their response on auto-pilot, so to speak. In each test, they had to take the entire process from the top, seeing a flash or no flash, and then figuring out which target to peck.</p><p>As all this occurred, the researchers monitored their neuronal activity. When Ozzie or Glenn saw a flash, sensory neurons fired and then stopped as the bird worked out which target to peck. When there was no flash, no firing of the sensory neurons was observed before the crow paused to figure out the correct target.</p><p>Nieder's Interpretation of this sequence is that Ozzie or Glenn had to see or not see a flash, deliberately note that there had or hadn't been a flash — exhibiting self-awareness of what had just been experienced — and then, in a few moments, connect that recollection to their knowledge of the current rule key before pecking the correct target.</p><p>During those few moments after the sensory neuron activity had died down, Nieder reported activity among a large population of neurons as the crows put the pieces together preparing to report what they'd seen. Among the busy areas in the crows' brains during this phase of the sequence was, not surprisingly, the pallium.</p><p>Overall, the study may eliminate the layered cerebral cortex as a requirement for higher intelligence. As we learn more about the intelligence of crows, we can at least say with some certainty that it would be wise to avoid <a href="https://www.nytimes.com/2008/08/26/science/26crow.html" target="_blank" rel="noopener noreferrer">angering one</a>.</p>
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