David Goggins
Former Navy Seal
Career Development
Bryan Cranston
Critical Thinking
Liv Boeree
International Poker Champion
Emotional Intelligence
Amaryllis Fox
Former CIA Clandestine Operative
Chris Hadfield
Retired Canadian Astronaut & Author
from the world's big
Start Learning

Flu season is here. Researchers may have discovered a cure.

Ferrets are not humans, but this new drug is showing promise.

Tablets are pictured in front of a cup of tea on February 05, 2019 in Berlin, Germany.
Photo Illustration by Florian Gaertner/Getty Images
  • Researchers at Georgia State University and Emory University tweaked an old drug and found great results.
  • None of the ferrets given EIDD-2801 twelve hours after infection developed the flu.
  • Those given the drug a day later developed less severe symptoms than the control group or those receiving Tamiflu.

Disease is part of the price we pay as biological organisms. Contemplating how many diseases we have not eradicated can be daunting, though in reality, since the discovery of vaccination in the late eighteenth century and widespread acceptance of germ theory in the nineteenth, researchers have made great strides in medicine. Formerly deadly diseases are now behind us.

Not every illness is easy to overcome, however. Cancer, as Siddhartha Mukherjee writes in his opus on the topic, is an inherent part of our biology; whether or not those cells get turned on is the grim game of change every one of us faces. Optimize all we like, the possibility is always lurking.

A disease we often overlook in this conversation due to its ubiquity is one most everyone has fallen victim to once (or many times) in their lives: influenza. The flu killed a record number of Americans in 2017-18: 80,000 citizens died that year, according to the CDC.

Even in an average year, the agency states that between 12,000 and 79,000 people die. Yet many more are struck ill—somewhere around nine million up to 50 million. That's nearly one-sixth of the population during especially bad seasons. Globally, over 600,000 people die every single year.

The flu isn't one disease, but a family of viruses. Knowing which will strike in any given year requires educated guessing. (Since Australia experiences its season earlier than America, our flu shots are based on what happens across the planet.) Three of the four influenza viruses affect humans, though there is speculation that the fourth might also make us sick.

It doesn't really matter which virus gets into your system. They're all terrible, and, for the youngest and oldest among us, potentially deadly. Sadly, as with antibiotics, flu drugs are showing less efficacy, as the virus has developed resistance to a popular remedy, oseltamivir (commonly known as Tamiflu).

Hope springs eternal, however. A new study, published in the journal, Science Translational Medicine, is showing promise—in ferrets. Researchers at Georgia State University and Emory University teamed up to test N-hydroxycytidine (NHC) on those polecats; previous research on macaques didn't go well: the medicine wasn't effective in preventing or treating flu symptoms because their bodies couldn't convert the drug.

This time, the researchers created a new compound, EIDD-2801, a minor tweaking of NHC. When the ferrets were infected with the flu and given a round of this new compound twelve hours later, not one of them got sick. Those given the drug a day after infection exhibited fewer symptoms than the control group or the group given Tamiflu.

Influenza - causes, symptoms, diagnosis, treatment, pathology

Andrew Pavia, an infectious disease expert at the University of Utah, breaks it down:

"It's important that they showed a reduction in symptoms in ferrets, because it gets much closer to predicting what happens in people. It's a major step towards developing a drug for humans."

Ferrets are not people, of course, so efficacy and dosage are up for debate. But it's an important potential breakthrough. The team writes,

"In conclusion, our data identify EIDD-2801 as a promising clinical candidate for monotherapy of seasonal and pandemic influenza. Although SI values defined by the human airway epithelia model are encouraging and no gross signs of toxicity were observed in the corresponding ferret efficacy studies, formal two-species multiday toxicity and adverse event testing will determine first-in-human dose concentrations."

Trials on humans are likely to begin next spring, so we'll have to make due with Tamiflu and that old cure-all, sleep and hydration, for a bit longer. Of course, getting your flu shot as soon as possible is also a good idea. Regardless of this season, this new research is an advancement in treating one of the world's most common diseases. Over a half-million lives every year depend on such a development.


Stay in touch with Derek on Twitter and Facebook.

Take your career to the next level by raising your EQ

Emotional intelligence is a skill sought by many employers. Here's how to raise yours.

  • Daniel Goleman's 1995 book Emotional Intelligence catapulted the term into widespread use in the business world.
  • One study found that EQ (emotional intelligence) is the top predictor of performance and accounts for 58% of success across all job types.
  • EQ has been found to increase annual pay by around $29,000 and be present in 90% of top performers.
Keep reading Show less

Yale scientists restore cellular function in 32 dead pig brains

Researchers hope the technology will further our understanding of the brain, but lawmakers may not be ready for the ethical challenges.

Still from John Stephenson's 1999 rendition of Animal Farm.
Surprising Science
  • Researchers at the Yale School of Medicine successfully restored some functions to pig brains that had been dead for hours.
  • They hope the technology will advance our understanding of the brain, potentially developing new treatments for debilitating diseases and disorders.
  • The research raises many ethical questions and puts to the test our current understanding of death.
Keep reading Show less

Face mask study reveals worst material for blocking COVID-19

A study published Friday tested how well 14 commonly available face masks blocked the emission of respiratory droplets as people were speaking.

Fischer et al.
  • The study tested the efficacy of popular types of face masks, including N95 respirators, bandanas, cotton-polypropylene masks, gaiters, and others.
  • The results showed that N95 respirators were most effective, while wearing a neck fleece (aka gaiter) actually produced more respiratory droplets than wearing no mask at all.
  • Certain types of homemade masks seem to be effective at blocking the spread of COVID-19.
Keep reading Show less

You want to stop child abuse? Here's how you can actually help.

Sharing QAnon disinformation is harming the children devotees purport to help.

Photo: Atjanan Charoensiri / Shutterstock
Politics & Current Affairs
  • The conspiracy theory, QAnon, is doing more harm than good in the battle to end child trafficking.
  • Foster youth expert, Regan Williams, says there are 25-29k missing children every year, not 800k, as marketed by QAnon.
  • Real ways to help abused children include donating to nonprofits, taking educational workshops, and becoming a foster parent.
Keep reading Show less
Strange Maps

Here’s a map of Mars with as much water as Earth

A 71% wet Mars would have two major land masses and one giant 'Medimartian Sea.'

Scroll down to load more…