The Platform That Gives Your Loved Ones Access To The Latest Innovative Treatments

Every year, millions of patients are told that they have exhausted conventional treatment options. With statistics showing the disturbing increase of cancer cases, it is unfortunately becoming common to have a loved one – relative or friend - suffering from the disease. There were an estimated 14.1 million cancer cases around the world in 2012. This number is expected to increase to 24 million by 2035 (WCRF). Having a loved one battling a disease such as cancer is a special kind of hell that only people who have experienced can really understand. It was exactly such people that created myTommorrows – a global platform, started in the Netherlands, that facilitates the contact between patients and innovative bio-tech companies.


MyTomorrows helps patients with terminal illnesses, such as cancer and motor neurone disease, who have exhausted conventional treatment options, to gain faster access to innovative drugs that have shown promising results during clinical trials, but are not officially registered yet.

In the 1960s it took 3 years for a drug to be approved. Now it takes almost 15 years. At the end of the 1980s AIDS patients did everything they could to find a solution. They obtained prohibited drugs from Mexico and broke into pharmaceutical companies. This personal experimentation and the social pressure created as a result accelerated the development of the AIDS inhibiting drugs prescribed today. Unfortunately, the illegal drug trade, with all of the risks that it involves, is still thriving in other areas of the healthcare market. We want to give patients who have reached the end of conventional treatment routes, and their doctors, legal new options. For more or better quality tomorrows. — Sjaak Vink, co-founder and CEO myTomorrows

MyTomorrows wants to help seriously ill patients that don’t have any treatment options left. The platform currently provides Fast Track treatments for several types of cancer and depression. A Fast Track Treatment offers early access to and up-to-date information about promising medicines that are not yet authorized, but have at least successfully finished phase I of a clinical trial. At that stage the medicine’s safety has been tested and there are promising efficacy indications. In order to take part in the treatment, patients need the support of their doctor who can request more detailed information, such as anonymized real life treatment data from other patients who started a Fast Track Treatment. Once the patient and the doctor have agreed on the treatment, myTommorrows coordinates the necessary request with the regulatory authorities and makes sure the medicine is made available to the hospital or the hospital pharmacy. 

The founders of myTomorrows believe that everyone should be able to choose earlier access to a promising medicine that might better his or her situation. Even though there are no guarantees about the efficacy of the selected treatments, it is the freedom of choice that the creators want to give back to those who have been told they have no more choice left. 

Learn more about the platform here.

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Why "nuclear pasta" is the strongest material in the universe

Through computationally intensive computer simulations, researchers have discovered that "nuclear pasta," found in the crusts of neutron stars, is the strongest material in the universe.

Accretion disk surrounding a neutron star. Credit: NASA
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  • The strongest material in the universe may be the whimsically named "nuclear pasta."
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Superman is known as the "Man of Steel" for his strength and indestructibility. But the discovery of a new material that's 10 billion times harder to break than steel begs the question—is it time for a new superhero known as "Nuclear Pasta"? That's the name of the substance that a team of researchers thinks is the strongest known material in the universe.

Unlike humans, when stars reach a certain age, they do not just wither and die, but they explode, collapsing into a mass of neurons. The resulting space entity, known as a neutron star, is incredibly dense. So much so that previous research showed that the surface of a such a star would feature amazingly strong material. The new research, which involved the largest-ever computer simulations of a neutron star's crust, proposes that "nuclear pasta," the material just under the surface, is actually stronger.

The competition between forces from protons and neutrons inside a neutron star create super-dense shapes that look like long cylinders or flat planes, referred to as "spaghetti" and "lasagna," respectively. That's also where we get the overall name of nuclear pasta.

Caplan & Horowitz/arXiv

Diagrams illustrating the different types of so-called nuclear pasta.

The researchers' computer simulations needed 2 million hours of processor time before completion, which would be, according to a press release from McGill University, "the equivalent of 250 years on a laptop with a single good GPU." Fortunately, the researchers had access to a supercomputer, although it still took a couple of years. The scientists' simulations consisted of stretching and deforming the nuclear pasta to see how it behaved and what it would take to break it.

While they were able to discover just how strong nuclear pasta seems to be, no one is holding their breath that we'll be sending out missions to mine this substance any time soon. Instead, the discovery has other significant applications.

One of the study's co-authors, Matthew Caplan, a postdoctoral research fellow at McGill University, said the neutron stars would be "a hundred trillion times denser than anything on earth." Understanding what's inside them would be valuable for astronomers because now only the outer layer of such starts can be observed.

"A lot of interesting physics is going on here under extreme conditions and so understanding the physical properties of a neutron star is a way for scientists to test their theories and models," Caplan added. "With this result, many problems need to be revisited. How large a mountain can you build on a neutron star before the crust breaks and it collapses? What will it look like? And most importantly, how can astronomers observe it?"

Another possibility worth studying is that, due to its instability, nuclear pasta might generate gravitational waves. It may be possible to observe them at some point here on Earth by utilizing very sensitive equipment.

The team of scientists also included A. S. Schneider from California Institute of Technology and C. J. Horowitz from Indiana University.

Check out the study "The elasticity of nuclear pasta," published in Physical Review Letters.


How a huge, underwater wall could save melting Antarctic glaciers

Scientists think constructing a miles-long wall along an ice shelf in Antarctica could help protect the world's largest glacier from melting.

Image: NASA
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The world's oceans will rise significantly over the next century if the massive ice shelves connected to Antarctica begin to fail as a result of global warming.

To prevent or hold off such a catastrophe, a team of scientists recently proposed a radical plan: build underwater walls that would either support the ice or protect it from warm waters.

In a paper published in The Cryosphere, Michael Wolovick and John Moore from Princeton and the Beijing Normal University, respectively, outlined several "targeted geoengineering" solutions that could help prevent the melting of western Antarctica's Florida-sized Thwaites Glacier, whose melting waters are projected to be the largest source of sea-level rise in the foreseeable future.

An "unthinkable" engineering project

"If [glacial geoengineering] works there then we would expect it to work on less challenging glaciers as well," the authors wrote in the study.

One approach involves using sand or gravel to build artificial mounds on the seafloor that would help support the glacier and hopefully allow it to regrow. In another strategy, an underwater wall would be built to prevent warm waters from eating away at the glacier's base.

The most effective design, according to the team's computer simulations, would be a miles-long and very tall wall, or "artificial sill," that serves as a "continuous barrier" across the length of the glacier, providing it both physical support and protection from warm waters. Although the study authors suggested this option is currently beyond any engineering feat humans have attempted, it was shown to be the most effective solution in preventing the glacier from collapsing.

Source: Wolovick et al.

An example of the proposed geoengineering project. By blocking off the warm water that would otherwise eat away at the glacier's base, further sea level rise might be preventable.

But other, more feasible options could also be effective. For example, building a smaller wall that blocks about 50% of warm water from reaching the glacier would have about a 70% chance of preventing a runaway collapse, while constructing a series of isolated, 1,000-foot-tall columns on the seafloor as supports had about a 30% chance of success.

Still, the authors note that the frigid waters of the Antarctica present unprecedently challenging conditions for such an ambitious geoengineering project. They were also sure to caution that their encouraging results shouldn't be seen as reasons to neglect other measures that would cut global emissions or otherwise combat climate change.

"There are dishonest elements of society that will try to use our research to argue against the necessity of emissions' reductions. Our research does not in any way support that interpretation," they wrote.

"The more carbon we emit, the less likely it becomes that the ice sheets will survive in the long term at anything close to their present volume."

A 2015 report from the National Academies of Sciences, Engineering, and Medicine illustrates the potentially devastating effects of ice-shelf melting in western Antarctica.

"As the oceans and atmosphere warm, melting of ice shelves in key areas around the edges of the Antarctic ice sheet could trigger a runaway collapse process known as Marine Ice Sheet Instability. If this were to occur, the collapse of the West Antarctic Ice Sheet (WAIS) could potentially contribute 2 to 4 meters (6.5 to 13 feet) of global sea level rise within just a few centuries."