Dementia is a broad term that covers several types of neurodegenerative disorders which affect a person’s ability to think, learn, recall memories, and perform everyday activities. This deterioration of the brain’s cognitive function is not considered part of the normal process of aging and it affects more than 47 million people worldwide, with 7.7 million new cases every year.
Alzheimer’s disease (AD) is the most common cause of dementia, contributing to 60-70% of cases and has a significant social and economical impact. Evidence suggests that changes on the molecular level that contribute to the development of the disease can occur as far back as 25 years prior to any noticeable symptoms.
Source: Alzheimer’s Association
Recently, researchers have been exploring the connection between AD and post‐traumatic stress disorder (PTSD). Epidemiological data shows that people with PTSD at a young age have an increased risk of developing AD in old age. A study from 2010, looked at data from 181,093 U.S. veterans and found that those diagnosed as having PTSD were nearly 2 times more likely to develop dementia compared with those without PTSD.
People with PTSD have an impaired mechanism, called fear extinction, that causes them to continue having a stress response to a stimulus that is no longer a threat. Normally, through processes like cognitive flexibility and extinction learning the individual would stop having such a response to the stimulus that once caused the traumatic event.
In a recently published study, scientists aimed to discover some of the mechanisms that link PTSD and AD. They observed that age‐associated memory decline is most likely a direct consequence of the reduced expression of a gene called Formin 2 (FMN2). Loss of FMN2 in young mice caused PTSD-like symptoms and also led to accelerated age-associated memory decline. In the tested mice deficits in fear extinction preceded the impairment of memory consolidation.
FMN2 has been associated with intellectual disability and is essential for extinction learning and cognitive flexibility. Both PTSD patients and AD patients have been shown to have a decreased FMN2 expression. The researchers determined that FMN2 levels are altered in blood samples from PTSD patients which may indicate that exposure to PTSD‐inducing events may alter FMN2 levels in the brain.
The link between dementia and PTSD has also been highlighted in another recent study, where researchers caution that delayed-onset post-traumatic symptoms in older people may be misdiagnosed as part of the symptoms of dementia.
Dr. Tarun Kuruvilla, senior author of the Progress in Neurology & Psychiatry review said:
“Every patient with dementia has a unique narrative, which if captured in the earlier stages of the disease, enables clinicians and their families to understand the origin of their distress. Therefore, it is important to look for a history of previous trauma in patients with BPSD as this could be due to delayed onset PTSD.”
U.S. Navy ships
The U.S. Navy controls patents for some futuristic and outlandish technologies, some of which, dubbed "the UFO patents," came to light recently. Of particular note are inventions by the somewhat mysterious Dr. Salvatore Cezar Pais, whose tech claims to be able to "engineer reality." His slate of highly-ambitious, borderline sci-fi designs meant for use by the U.S. government range from gravitational wave generators and compact fusion reactors to next-gen hybrid aerospace-underwater crafts with revolutionary propulsion systems, and beyond.
Of course, the existence of patents does not mean these technologies have actually been created, but there is evidence that some demonstrations of operability have been successfully carried out. As investigated and reported by The War Zone, a possible reason why some of the patents may have been taken on by the Navy is that the Chinese military may also be developing similar advanced gadgets.
Among Dr. Pais's patents are designs, approved in 2018, for an aerospace-underwater craft of incredible speed and maneuverability. This cone-shaped vehicle can potentially fly just as well anywhere it may be, whether air, water or space, without leaving any heat signatures. It can achieve this by creating a quantum vacuum around itself with a very dense polarized energy field. This vacuum would allow it to repel any molecule the craft comes in contact with, no matter the medium. Manipulating "quantum field fluctuations in the local vacuum energy state," would help reduce the craft's inertia. The polarized vacuum would dramatically decrease any elemental resistance and lead to "extreme speeds," claims the paper.
Not only that, if the vacuum-creating technology can be engineered, we'd also be able to "engineer the fabric of our reality at the most fundamental level," states the patent. This would lead to major advancements in aerospace propulsion and generating power. Not to mention other reality-changing outcomes that come to mind.
Among Pais's other patents are inventions that stem from similar thinking, outlining pieces of technology necessary to make his creations come to fruition. His paper presented in 2019, titled "Room Temperature Superconducting System for Use on a Hybrid Aerospace Undersea Craft," proposes a system that can achieve superconductivity at room temperatures. This would become "a highly disruptive technology, capable of a total paradigm change in Science and Technology," conveys Pais.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
Another invention devised by Pais is an electromagnetic field generator that could generate "an impenetrable defensive shield to sea and land as well as space-based military and civilian assets." This shield could protect from threats like anti-ship ballistic missiles, cruise missiles that evade radar, coronal mass ejections, military satellites, and even asteroids.
Dr. Pais's ideas center around the phenomenon he dubbed "The Pais Effect". He referred to it in his writings as the "controlled motion of electrically charged matter (from solid to plasma) via accelerated spin and/or accelerated vibration under rapid (yet smooth) acceleration-deceleration-acceleration transients." In less jargon-heavy terms, Pais claims to have figured out how to spin electromagnetic fields in order to contain a fusion reaction – an accomplishment that would lead to a tremendous change in power consumption and an abundance of energy.
According to his bio in a recently published paper on a new Plasma Compression Fusion Device, which could transform energy production, Dr. Pais is a mechanical and aerospace engineer working at the Naval Air Warfare Center Aircraft Division (NAWCAD), which is headquartered in Patuxent River, Maryland. Holding a Ph.D. from Case Western Reserve University in Cleveland, Ohio, Pais was a NASA Research Fellow and worked with Northrop Grumman Aerospace Systems. His current Department of Defense work involves his "advanced knowledge of theory, analysis, and modern experimental and computational methods in aerodynamics, along with an understanding of air-vehicle and missile design, especially in the domain of hypersonic power plant and vehicle design." He also has expert knowledge of electrooptics, emerging quantum technologies (laser power generation in particular), high-energy electromagnetic field generation, and the "breakthrough field of room temperature superconductivity, as related to advanced field propulsion."
Suffice it to say, with such a list of research credentials that would make Nikola Tesla proud, Dr. Pais seems well-positioned to carry out groundbreaking work.
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
The patents won't necessarily lead to these technologies ever seeing the light of day. The research has its share of detractors and nonbelievers among other scientists, who think the amount of energy required for the fields described by Pais and his ideas on electromagnetic propulsions are well beyond the scope of current tech and are nearly impossible. Yet investigators at The War Zone found comments from Navy officials that indicate the inventions are being looked at seriously enough, and some tests are taking place.
If you'd like to read through Pais's patents yourself, check them out here.
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
Can we hack sugar to be healthy? www.youtube.com
Humans consume too much sugar. This is a refrain you've likely read for years, if not decades. As with any generality, that topline assessment misses nuance. While certainly true that we over-consume sugar in the Western diet — added sugar goes by at least 61 names and has been found in 74 percent of processed foods — sugar itself is a necessary carbohydrate. In fact, core metabolic processes, like glycolysis and the Krebs cycle, largely revolve around the processing of glucose.
This fact has caused some researchers to ask: can we create healthy sugar?
A primer on sugar and fad diets
Trying to make sense of the market for sugar substitutes is not necessarily helpful. Reading a nutrition label with terms like coconut sugar, xylitol, sucralose, Ace-k, or non-GMO dextrose leaves consumers scratching their heads. The aggressive agave nectar marketing campaign a few years ago caused many companies to market their products as having "real sugar." (As opposed to what? Fake sugar?)
The biochemical story of what happens to this carbohydrate inside of the human body is complex, however, and rarely will be answered by a company trying to sell its wares.
Monosaccharides, a.k.a. "simple sugars," are quite common. Galactose, glucose, and fructose fall in this category. Compound sugars, a.k.a. disaccharides, include sucrose (table sugar), maltose, and lactose. Then there are chemicals like sugar alcohols and glycerol, which are sweet but not actually sugar.
Most plants contain sugar. Fruit and honey also contain readily available simple sugars. Two common sources for processed food sugars are sugarcane and sugar beets. The cheapest to produce is corn syrup, which has been at the heart of the sugar debate for years. Due to farm subsidies, an overproduction of corn has led to this class of sugars being ubiquitous in the Western diet. Biochemically, believe it or not, high-fructose corn syrup isn't all that different from honey.
Historically, sugar was a rare and valuable commodity, often hard-won through gnawing on sugarcane. Fruits provide a quick and reliable burst of energy through their high sugar content, an especially useful trait for hunter-gatherers who relied on such fuel. As humans became addicted to sweetness, eschewing other flavor profiles to get right to the sugar rush, we figured out how to produce (and overproduce) it rapidly.
Thus, we got diet fads like "juice cleanses," which offer a rush of sugar without the fiber that slows its absorption into your bloodstream. Fiber is the most important part of the fruit. Detoxifying through such cleanses is a myth. Given the climate for sweet alternatives and nutritional shortcuts, however, we've grown susceptible to flashy marketing over solid nutritional science.
Israeli food-tech company DouxMatok (Hebrew for "double sweet") has created a sugary product that uses 40 percent less actual sugar yet still tastes like the sucrose that you would find in many products. The team noticed that our sweet receptors only detect about 20 percent of the sugar molecules that we consume, meaning the other 80 percent goes right into our bodies unnoticed by our mouths.
Health risks of sugar
Sugar science is constantly evolving. The WHO currently recommends a maximum of five to ten teaspoons (roughly 50 grams) of added sugar per day. To put that into perspective, Americans average 17 teaspoons (71 grams) per day — a whopping 57 pounds of sugar every year. One can of Coke contains nearly 10 teaspoons of sugar. Orange juice isn't much better.
This excess sugar leads to many potential health problems. A 2014 study in JAMA Internal Medicine states it bluntly: people who received between 17 and 21 percent of their daily calories from sugar had a 38 percent higher risk of dying from cardiovascular disease than those who consumed 8 percent of their calories from sugar. Harvard nutrition professor Dr. Frank Hu summarized his research with a simple assessment: "Basically, the higher the intake of added sugar, the higher the risk for heart disease."
The problems don't stop there. Sugar is metabolized similarly in the liver as alcohol — indeed, many alcoholic beverages contain high amounts of sugar — and the carbohydrates are turned into fat. As you gain weight, the health problems continue to escalate.
Issues with overconsumption of sugar include:
- High blood pressure. A 2014 study suggests that sugar might be worse for your blood pressure than salt. Along with an increase in insulin, sugar elevates heart rate and blood pressure by activating the sympathetic nervous system. Sugar was also found to reduce the sensitivity of blood pressure receptors and deplete cellular energy stores (ATP), both of which increase blood pressure.
- Diabetes. Type 2 diabetes is the primary problem with excess sugar intake, given that your body becomes resistant to insulin, causing sugar to build up in your blood. Sugar intake is not the only cause (genetics plays a role), though excess belly weight is clearly linked to the development of diabetes.
- Fatty liver disease. Excess fatty build-up in the liver leads to this disease. While common in alcoholics, some research suggests that sugar also negatively impacts the liver.
- Inflammation. While inflammation is essential for our body's self-repair process, excess sugar has been linked to chronic low-grade inflammation. In fact, just 40 grams per day has been demonstrated to have adverse inflammatory effects. While this is problematic in itself, inflammation can trigger many other health problems as well.
- Dementia. The science is less clear here, though some research has found that sugar impacts memory due to increased bodily inflammation.
- Tooth decay. For healthy teeth, it is ideal to keep your sugar intake to under 10 percent of total calories. The WHO found that excess sugar intake is the number one dietary factor for the development of cavities.
Photo: aboikos / Adobe Stock
Common sugar substitutes
Regardless of negative health effects, people love sweet foods. The desire for sweet-tasting foods is biologically programmed into us. The problem isn't eating sugar-rich foods per se; it's excessive consumption. Public health advice to cut down isn't working, and so a lot of companies are trying to offer alternatives.
High-intensity sweeteners are the most common substitute. These compounds are much sweeter than table sugar, meaning you need less of them in order to achieve the same level of sweetness. In America, there are six FDA-approved sweeteners in this category:
- Aspartame
- Sucralose
- Neotame
- Acesulfame potassium (Ace-K)
- Saccharin
- Advantame
Other common sugar substitutes include Stevia, sugar alcohols, honey, and agave nectar.
Acesulfame Potassium (Ace-K). Most commonly known under its trade names, Sunett and Sweet One, this potassium salt was first discovered in 1967. Two hundred times sweeter than common sugar, research has shown that Ace-K has no effect on body weight. Concerns over its possible carcinogenic effects were dismissed by the FDA, though as with all sugar substitutes, research is ongoing.
Advantame. This non-caloric sweetener is a whopping 20,000 times sweeter than sucrose and is commonly used in gum, drinks, and candy. It is approved in the U.S. as a flavor enhancer except in meat and poultry. It was recognized as safe by the European Food Safety Authority in 2013.
Agave syrup. This sweetener from the agave cactus was commonly used in health circles for years. It contains 56 percent fructose and dissolves quickly, making it ideal for cooking. Blue-agave syrup is between 1.4 and 1.6 times sweeter than sugar, though, and being over half fructose in composition, it also has many of the same detrimental effects as sugar.
Aspartame. As with Ace-K, aspartame is 200 times sweeter than sucrose. First approved by the FDA in 1981, this peptide is one of the most widely tested food ingredients and has been found to be safe. That said, people who suffer from a rare inherited disease, phenylketonuria, cannot consume aspartame, which is why any foods sold in America must list this ingredient with a warning label.
Honey. Foods featuring honey are often marketed as containing "real honey," though in reality, its composition is similar to sucrose (it contains fructose and glucose), and it is roughly as sweet as sucrose. Anyone consuming honey should heed the same warnings as with common sugar.
Neotame. The aspartame analog, created by NutraSweet, is 8,000 times sweeter than sugar. First approved by the FDA in 2002, Neotame is common in colas, gums, yogurts, cakes, and drink powders. It's also used to cover the bitter taste of coffee.
Saccharin. This well-known sodium salt is roughly 400 times sweeter than common sugar. While used in numerous drinks, candies, and even medicine, it produces a metallic aftertaste. Considered safe for diabetics, saccharin has no nutritional value and is generally safe — though, anyone with an allergy to sulfonamide could experience symptoms after consuming saccharin.
Stevia. Derived from the South American Stevia rebaudiana plant, it's "generally recognized as safe" by the FDA. Up to 150 times sweeter than sucrose, stevia is a common additive in many health food products, though some consumers don't like its bitter aftertaste. The plant itself has been in use for at least 1,500 years as a tea sweetener and medicine.
Sugar alcohols. Sugar alcohols have been all the rage in keto products over the last few years. Otherwise known as polyols, they are actually less sweet than sugar, marketed for not spiking blood glucose levels. Common sugar alcohols include sorbitol, xylitol, and lactitol. This family of sweeteners is considered safe.
Sucralose. Six hundred times sweeter than sugar, sucralose is the most common artificial sweetener in the world. Deemed safe by governing bodies in America, New Zealand, Australia, Canada, and Europe, it is appropriate for diabetics and does not cause tooth decay. The most common iteration of sucralose is Splenda, which is mixed with maltodextrin and dextrose and sold worldwide.
Can sugar be good for you?
The question of whether sugar can be good for you is common but based on an incorrect assumption: we must consume sugar. Our bodies rely on carbohydrates for energy, and carbs are all ultimately turned into sugars. If you were to only eat protein and fat, you would quickly encounter numerous other health problems. The question isn't whether sugar is good but how much and in what form it should be consumed.
For example, glucose and maltodextrin are high glycemic additives, whereas sucrose is moderate and agave syrup and fructose are low. High glycemic foods are known to give you a "sugar crash," which is a spike in blood sugar followed by a rapid fall in levels. High glycemic foods should generally be avoided.
But what about for people who exercise a lot? If you don't exercise often, sugar will be turned into fat, leading to a cascade of health problems. For endurance athletes, however, sugar is a necessary fuel for training.
Athletes and people who regularly exercise can benefit from high glycemic foods because our bodies recognize the intake as fuel for the activity. Whereas you would mostly want to consume low glycemic foods when not exercising, using a mix of maltodextrin and fructose during or after exercise is a smart choice. In fact, consuming low glycemic foods while exercising can cause stomach bloating.
Photo: veineleissa / Adobe Stock
What is the daily recommended sugar intake?
As mentioned above, the recommended daily allowance (RDA) of sugar caps at 10 teaspoons for adults. The latest edition of federal dietary guidelines offers a bit more detail, however.
- Americans older than two years should cap their added sugar intake to no more than 10 percent of total calories. "Added sugar" is important because, as mentioned, all carbohydrates eventually turn into sugar in your body. Eating whole fruit doesn't count in this total; soft drinks and fruit juices do.
- Children under age two are advised to avoid foods with added sugars.
How is DouxMatok trying to create the healthiest sweetener on the market?
As mentioned earlier, our sweet receptors only recognize 20 percent of the common sugar we consume. Israeli food-tech company DouxMatok was founded by Professor Avraham Baniel, who in 2014, at the age of 96, applied his 75 years of industrial chemical research experience to create Incredo® Sugar. While the start-up aspires to create tastier and healthier variations of a variety of foods (including salt), sugar was the most pressing issue Baniel and his son, Eran, wanted to solve.
DouxMatok is not alone in this quest. For example, global food giant Nestle produced its own sugar reduction in a "healthier" candy bar called Milkybar Wowsomes. The experiment didn't end well as the company had to pull the item from shelves due to low consumer demand. Matching the flavor profile, density, and texture of sugar is harder than it sounds.
Nestle hasn't abandoned the quest for sugar alternatives, however. Companies realize their bottom line depends on offering healthier sugar without sacrificing taste and affordability — the same quest that meat alternative companies have been facing for years. While stevia and aspartame are widely used, for example, some consumers recognize the metallic taste and opt for what they know best. This will remain a real barrier until scientists can dial in an alternative that performs well in blind taste tests.
Incredo® Sugar is a sugar reduction created from cane or beet sugar. As the video at the top of the article shows, at least one anecdotal study in the Freethink office scored favorably for DouxMatok. The race is still on. DouxMatok's initial creation doesn't work well in liquids, at least not yet. Also, you can't cook with it on your own; the company is focused on using their sugar alternative in consumer food products first.
As Dr. Robert Margolskee, Director of the Monell Chemical Senses Center, says of the possible timeline, "I think within five years we'll be able to reduce 80 to 90 percent of the sugar in a food and still get pretty much the full sugar sensation. It's not an impossible dream."--
Stay in touch with Derek on Twitter. His most recent book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."
