For the First Time Tiny Robots Treat Infection in a Living Organism


Scientists from the department of NanoEngineering at the University of California San Diego were able to successfully use chemically-powered micromotors to deliver antibiotics in the gut of a mouse and treat a gastric bacterial infection. It is the first use of such technology in a living organism and could pave the way for further applications in treating various types of diseases. The study was published in Nature Communications

The bacteria that caused the infection is called H.pylori - a common type found in the digestive tract of more than half of all people in the world. H.pylori can cause ulcers in the stomach and the small intestine as well as gastritis. The bacteria is capable of living in the acidic environment of the stomach and can also penetrate the stomach lining where immune cells are not capable of reaching it.

The acidic environment of the stomach and the location of the bacteria makes antibiotic treatment difficult. Antibiotics have to be administered with proton pump inhibitors (PPIs) to reduce the production of gastric acid and preserve the effectiveness of the drugs. Unfortunately, the use of PPIs can cause other problems in the long term, like headaches, diarrhea and even anxiety and depression. This is why a treatment that can effectively deliver the antibiotics without the use of PPIs could be very beneficial.

The scientists created tiny motors made of a spherical magnesium core, covered with several layers. One layer carried the antibiotic and another enabled adhesion to the stomach wall, enabling localized delivery. The motors were propelled by the stomach acid, which was used as a fuel via a chemical reaction. This reaction also temporarily reduced the acidic environment.  

The treatment proved more effective than regular antibiotic treatment. In addition, stomach pH was restored within 24 hours, while the motors themselves dissolved, leaving no signs of toxicity.

According to the researchers, this study and its favorable results open the door to the use of synthetic motors to deliver treatments for other diseases as well. 

Stand up against religious discrimination – even if it’s not your religion

As religious diversity increases in the United States, we must learn to channel religious identity into interfaith cooperation.

Sponsored by Charles Koch Foundation
  • Religious diversity is the norm in American life, and that diversity is only increasing, says Eboo Patel.
  • Using the most painful moment of his life as a lesson, Eboo Patel explains why it's crucial to be positive and proactive about engaging religious identity towards interfaith cooperation.
  • The opinions expressed in this video do not necessarily reflect the views of the Charles Koch Foundation, which encourages the expression of diverse viewpoints within a culture of civil discourse and mutual respect.
Keep reading Show less

NASA's idea for making food from thin air just became a reality — it could feed billions

Here's why you might eat greenhouse gases in the future.

Jordane Mathieu on Unsplash
Technology & Innovation
  • The company's protein powder, "Solein," is similar in form and taste to wheat flour.
  • Based on a concept developed by NASA, the product has wide potential as a carbon-neutral source of protein.
  • The man-made "meat" industry just got even more interesting.
Keep reading Show less

Where the evidence of fake news is really hiding

When it comes to sniffing out whether a source is credible or not, even journalists can sometimes take the wrong approach.

Sponsored by Charles Koch Foundation
  • We all think that we're competent consumers of news media, but the research shows that even journalists struggle with identifying fact from fiction.
  • When judging whether a piece of media is true or not, most of us focus too much on the source itself. Knowledge has a context, and it's important to look at that context when trying to validate a source.
  • The opinions expressed in this video do not necessarily reflect the views of the Charles Koch Foundation, which encourages the expression of diverse viewpoints within a culture of civil discourse and mutual respect.
Keep reading Show less