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How psychedelics help you "die before you die"
The heart of the religious ritual is mysticism, argues Brian Muraresku in "The Immortality Key."
- The concept of "dying before you die" lies at the heart of religious tradition, argues Brian Muraresku.
- This secret ritual connects the Eleusinian Mysteries with the origins of Christianity.
- In "The Immortality Key," Muraresku speculates that psychedelic wine could have been the original Christian Eucharist.
After a 20-year ban on clinical psychedelics research, the U.S. government approved trials on DMT in 1990. At first, Rick Strassman, a clinical associate professor of psychiatry at the University of New Mexico School of Medicine, only wanted to study the physiological strain of injecting DMT: heart rate, blood pressure, and so on. Given that psychedelics had been contentiously demonized for a generation, he wondered if physical consequences were as dangerous as advertised.
LSD had been administered tens of thousands of times in the 1950s and early 1960s. Did it really fry your brain like eggs, as the Reagans so confidently declared?
Over the next five years, Strassman administered 400 doses of N,N-dimethyltryptamine (DMT) to over 50 volunteers. It turned out that DMT, the fast-acting psychoactive ingredient in ayahuasca—the "soul vine" persists for hours only when blended with MAOIs to slow the breakdown of enzymes in your gut—has few negative effects. A longtime Zen Buddhist practitioner, Strassman noticed something else going on when over half of participants reported having profound religious experiences.
They were dying before dying.
Well, some of them were being visited by alien creatures, a phenomenon MAPS founder Rick Doblin possibly attributes to the "setting" part of "set and setting": tripping out in a sterile hospital room surrounded by clinicians in white lab coats certainly felt foreign, perhaps otherworldly. Other volunteers saw a beautiful light at the end of a tunnel and returned—a sensation noted in the ayahuasca literature for as long as we have records.
DMT is chemically related to serotonin and melatonin. The latter hormone is produced by the pineal gland, which is symbolically called the "third eye"—Descartes famously called it the "seat of the soul." Since every mammal that's been tested (including humans) produce endogenous DMT, could our third eye possibly release this structural analog of tryptamine at death? Is it a coincidence that the pineal gland, according to Strassman, appears in fetuses at 49 days, the exact duration of the "passage" of souls described in The Tibetan Book of the Dead?
Strassman admits this is speculation. The anecdotes are irrefutable, however. His clinical work led to Charles Grob's government-approved research on ayahuasca and MDMA in the 1990s, which opened the door to Johns Hopkins researchers studying psilocybin to treat the existential dread hospice patients encounter, which opened the floodgates to the psychedelic revolution occurring today.That initial Johns Hopkins study, which found that psilocybin (structurally similar to DMT) eases distress by helping initiates die before they die, helped give form to Brian Muraresku's 12-year journey while writing his debut book, "The Immortality Key: The Secret History of the Religion With No Name."
Brian Muraresku explains the potential role of psychedelics in Christianity
Muraresku has been getting a lot of press since the book's publication, in part boosted by his appearance on Joe Rogan's podcast. The classicist speculates that the Christian Eucharist is rooted in the Eleusinian Mysteries, which may have involved the ceremonial ingestion of wine spiked with psychedelic ingredients. The idea of a psychedelic Christianity is not new, but Muraresku brings a detailed level of scholarship and compassion to the topic.
As he told me in a recent interview, the "immortality key" is not psychedelics, but the concept of dying before dying. He opens his book with a Greek inscription: "If you die before you die / You won't die when you die." Muraresku, a devout Catholic raised in the Jesuit tradition, kicks off the discussion with an atheist from the Johns Hopkins trial. Despite her lack of faith, she felt an "overwhelming, all-encompassing love" that helped her deal with the inevitable consequences of mixed-cell ovarian cancer—really, the inevitable consequences of being an animal bound to die.
The Hopkins study went mainstream when Michael Pollan wrote about it in the New Yorker. The results were stunning: 70 percent of participants felt a single dose of psilocybin produced the most meaningful (or among the top five) experience of their lives. Interestingly, the same result occurred after the famous Marsh Chapel experiment, when Timothy Leary and friends dosed Harvard Divinity School grad students with psilocybin; a quarter-century later, all but one rated the event in their top five.
Not only do you die before you die while under the influence of psychedelics, but you also gain a new perspective on life. The ego death that occurs during the ritual changes their orientation about existence. And what good is a religious experience if it can't be applied to living?
As Muraresku told me,
"[Psychedelics] is one tool in the Spiritual Toolkit. What I mean by 'the key' is in Greek, which is preserved at St. Paul's monastery: if you die before you die, you won't die when you die. That's the actual key. It's not psychedelics, it's not drugs; it's this concept of navigating the liminal space between what you and I are doing right now, and dreaming and death. In that state, the mystics and sages tell us, is the potential to grasp a very different view of reality."Muraresku taps into a growing consensus that humans are "wired" for mystical experiences. He points to lead Johns Hopkins researcher, Roland Griffiths, who believes that mysticism is included in our operating system at birth. You just have to turn it on. While the effects of psychedelics can be replicated through the more arduous path of meditation, in the right set and setting anyone can tap into mystical states of consciousness. Psychedelics provide a shortcut to these states.
Credit: Galyna Andrushko / Adobe Stock
Western religious leaders, especially those in Christianity and Islam, treat their prophets as standalone figures. The best you can hope for is being granted access to some special place after you die. Gnostics and Sufis—sects within those faiths that attempt to replicate their prophet's mysticism—are considered outcasts by mainstream religious figures. In some circumstances, they're outlawed, threatened, or even killed for their supposed heresy.
Sufis might spin for hours in ecstatic rapture to reach this mystical state, but as Muraresku's extensive research shows, psychedelics also tap into this "secret" knowledge that he believes to be at the heart of Christian—and if we extrapolate, religious—tradition. And to him, this is the essence of the religion, not a byproduct of the real faith.
"I didn't write this book to be anti-organized religion. In some cases, it's the exact opposite. In the intro, I mentioned Brother David Steindl-Rast, a Benedictine monk who is a hero of mine. He talks about the tension between mystics and the dogma and doctrine of organized faith. I don't think you can have one without the other. The balance, as Brother David says, is to rediscover that original visionary power and live in it as a lived experience. This is what Joseph Campbell says of religion being a lived experience. We're talking about emotional potential. That's how the great anthropologist Clifford Geertz defines religion: these powerful, pervasive, long-lasting moods and motivations. That only happens when you're talking about something that gets inside of people's bones. That's what the mystical experience is; it's how these religions are born. Brother David says it's virtually impossible to start a religion without mystical experience, like Moses in the burning bush, Paul on the road to Damascus, or Peter, in Acts, caught up in a trance."
Campbell's conversation with Bill Moyers in "The Power of Myth" nicely ties together this idea:
"People say that what we're all seeking is a meaning for life. I don't think that's what we're really seeking. I think that what we're seeking is an experience of being alive, so that our life experiences on the purely physical plane will have resonances with our own innermost being and reality, so that we actually feel the rapture of being alive."
The mythologist also advocated for a reformation of religion every generation so that the faith speaks to the times. This is effectively what Muraresku advocates for in "The Immortality Key": an honest conversation regarding the historical circumstances that birthed the world's most-followed religion in the hopes of applying the foundational lessons to our current reality. If that means a psychedelic ritual that shows you how to die before you die so that you may better know how to live, then it's time to rethink the role of the sacrament.
Mysticism is a universal phenomenon. The "eternal return" Mircea Eliade wrote about has been experienced throughout history in disparate regions of the world. As Strassman's and Griffiths's work shows, we retain the capability of dying before dying. In fact, current research on psilocybin, LSD, iboga, DMT, and ayahuasca show that these substances are helping people gain a perspective of their lives, be it in depression treatment, addiction recovery, or easing the pain of hospice care. A little mysticism goes a long way.
Let's move beyond this notion that mysticism only applies to a chosen few. In fact, let's reconsider the role of consciousness in general. Every religion has its own take on what happens after we die. Yet we have tools at our disposal to show us how to exist now: a living religion that speaks to the entire planet.
Stay in touch with Derek on Twitter and Facebook. His new book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."
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Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.
- U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
- Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
- While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
The U.S. Navy controls patents for some futuristic and outlandish technologies, some of which, dubbed "the UFO patents," came to light recently. Of particular note are inventions by the somewhat mysterious Dr. Salvatore Cezar Pais, whose tech claims to be able to "engineer reality." His slate of highly-ambitious, borderline sci-fi designs meant for use by the U.S. government range from gravitational wave generators and compact fusion reactors to next-gen hybrid aerospace-underwater crafts with revolutionary propulsion systems, and beyond.
Of course, the existence of patents does not mean these technologies have actually been created, but there is evidence that some demonstrations of operability have been successfully carried out. As investigated and reported by The War Zone, a possible reason why some of the patents may have been taken on by the Navy is that the Chinese military may also be developing similar advanced gadgets.
Among Dr. Pais's patents are designs, approved in 2018, for an aerospace-underwater craft of incredible speed and maneuverability. This cone-shaped vehicle can potentially fly just as well anywhere it may be, whether air, water or space, without leaving any heat signatures. It can achieve this by creating a quantum vacuum around itself with a very dense polarized energy field. This vacuum would allow it to repel any molecule the craft comes in contact with, no matter the medium. Manipulating "quantum field fluctuations in the local vacuum energy state," would help reduce the craft's inertia. The polarized vacuum would dramatically decrease any elemental resistance and lead to "extreme speeds," claims the paper.
Not only that, if the vacuum-creating technology can be engineered, we'd also be able to "engineer the fabric of our reality at the most fundamental level," states the patent. This would lead to major advancements in aerospace propulsion and generating power. Not to mention other reality-changing outcomes that come to mind.
Among Pais's other patents are inventions that stem from similar thinking, outlining pieces of technology necessary to make his creations come to fruition. His paper presented in 2019, titled "Room Temperature Superconducting System for Use on a Hybrid Aerospace Undersea Craft," proposes a system that can achieve superconductivity at room temperatures. This would become "a highly disruptive technology, capable of a total paradigm change in Science and Technology," conveys Pais.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
Another invention devised by Pais is an electromagnetic field generator that could generate "an impenetrable defensive shield to sea and land as well as space-based military and civilian assets." This shield could protect from threats like anti-ship ballistic missiles, cruise missiles that evade radar, coronal mass ejections, military satellites, and even asteroids.
Dr. Pais's ideas center around the phenomenon he dubbed "The Pais Effect". He referred to it in his writings as the "controlled motion of electrically charged matter (from solid to plasma) via accelerated spin and/or accelerated vibration under rapid (yet smooth) acceleration-deceleration-acceleration transients." In less jargon-heavy terms, Pais claims to have figured out how to spin electromagnetic fields in order to contain a fusion reaction – an accomplishment that would lead to a tremendous change in power consumption and an abundance of energy.
According to his bio in a recently published paper on a new Plasma Compression Fusion Device, which could transform energy production, Dr. Pais is a mechanical and aerospace engineer working at the Naval Air Warfare Center Aircraft Division (NAWCAD), which is headquartered in Patuxent River, Maryland. Holding a Ph.D. from Case Western Reserve University in Cleveland, Ohio, Pais was a NASA Research Fellow and worked with Northrop Grumman Aerospace Systems. His current Department of Defense work involves his "advanced knowledge of theory, analysis, and modern experimental and computational methods in aerodynamics, along with an understanding of air-vehicle and missile design, especially in the domain of hypersonic power plant and vehicle design." He also has expert knowledge of electrooptics, emerging quantum technologies (laser power generation in particular), high-energy electromagnetic field generation, and the "breakthrough field of room temperature superconductivity, as related to advanced field propulsion."
Suffice it to say, with such a list of research credentials that would make Nikola Tesla proud, Dr. Pais seems well-positioned to carry out groundbreaking work.
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
The patents won't necessarily lead to these technologies ever seeing the light of day. The research has its share of detractors and nonbelievers among other scientists, who think the amount of energy required for the fields described by Pais and his ideas on electromagnetic propulsions are well beyond the scope of current tech and are nearly impossible. Yet investigators at The War Zone found comments from Navy officials that indicate the inventions are being looked at seriously enough, and some tests are taking place.
If you'd like to read through Pais's patents yourself, check them out here.
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
Scientists do not know what is causing the overabundance of the gas.
- A new study looked to understand the source of methane on Saturn's moon Enceladus.
- The scientists used computer models with data from the Cassini spacecraft.
- The explanation could lie in alien organisms or non-biological processes.
Something is producing an overabundance of methane in the ocean hidden under the ice of Saturn's moon Enceladus. A new study analyzed if the source could be an alien life form or some other explanation.
The study, published in Nature Astronomy, was carried out by scientists at the University of Arizona and Paris Sciences & Lettres University, who looked at composition data from the water plumes erupting on Enceladus.
The particular chemistry, discovered by the Cassini spacecraft which flew through the plumes, suggested a high concentration of molecules that have been linked to hydrothermal vents on the bottom of Earth's oceans. Such vents are potential cradles of life on Earth, according to previous studies. The data from Cassini, which has been studying Saturn after entering its orbit in 2004, revealed the presence of molecular hydrogen (dihydrogen), methane, and carbon dioxide, with the amount of methane presenting a particular interest to the scientists."We wanted to know: Could Earthlike microbes that 'eat' the dihydrogen and produce methane explain the surprisingly large amount of methane detected by Cassini?" shared one of the study's lead authors Régis Ferrière, an associate professor in the department of Ecology and Evolutionary Biology at the University of Arizona.
Earth's hydrothermal vents feature microorganisms that use dihydrogen for energy, creating methane from carbon dioxide via the process of methanogenesis.
Searching for such microorganisms known as methanogens on the seafloor of Enceladus is not yet feasible. Likely, it would require very sophisticated deep diving operations that will be the objective of future missions.
So, Ferrière's team took a more available approach to pinpointing the origins of the methane, creating mathematical models that attempted to explain the Cassini data. They wanted to calculate the likelihood that particular processes were responsible for producing the amount of methane observed. For example, is the methane more likely the result of biological or non-biological processes?
They found that the data from Cassini was consistent with either microbial activity at hydrothermal vents or processes that have nothing to do with life but could be quite different from what happens on Earth. Intriguingly, models that didn't involve biological entities didn't seem to produce enough of the gas.
"Obviously, we are not concluding that life exists in Enceladus' ocean," Ferrière stated. "Rather, we wanted to understand how likely it would be that Enceladus' hydrothermal vents could be habitable to Earthlike microorganisms. Very likely, the Cassini data tell us, according to our models."
Still, the scientists think future missions are necessary to either prove or discard the "life hypothesis." One explanation for the methane that does not involve biological organisms is that the gas is the result of a chemical breakdown of primordial organic matter within Enceladus' core. This matter could have become a part of Saturn's moon from comets rich in organic materials.
It marks a breakthrough in using gene editing to treat diseases.
This article was originally published by our sister site, Freethink.
For the first time, researchers appear to have effectively treated a genetic disorder by directly injecting a CRISPR therapy into patients' bloodstreams — overcoming one of the biggest hurdles to curing diseases with the gene editing technology.
The therapy appears to be astonishingly effective, editing nearly every cell in the liver to stop a disease-causing mutation.
The challenge: CRISPR gives us the ability to correct genetic mutations, and given that such mutations are responsible for more than 6,000 human diseases, the tech has the potential to dramatically improve human health.
One way to use CRISPR to treat diseases is to remove affected cells from a patient, edit out the mutation in the lab, and place the cells back in the body to replicate — that's how one team functionally cured people with the blood disorder sickle cell anemia, editing and then infusing bone marrow cells.
Bone marrow is a special case, though, and many mutations cause disease in organs that are harder to fix.
Another option is to insert the CRISPR system itself into the body so that it can make edits directly in the affected organs (that's only been attempted once, in an ongoing study in which people had a CRISPR therapy injected into their eyes to treat a rare vision disorder).
Injecting a CRISPR therapy right into the bloodstream has been a problem, though, because the therapy has to find the right cells to edit. An inherited mutation will be in the DNA of every cell of your body, but if it only causes disease in the liver, you don't want your therapy being used up in the pancreas or kidneys.
A new CRISPR therapy: Now, researchers from Intellia Therapeutics and Regeneron Pharmaceuticals have demonstrated for the first time that a CRISPR therapy delivered into the bloodstream can travel to desired tissues to make edits.
We can overcome one of the biggest challenges with applying CRISPR clinically.
"While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," she continued.
What they did: During a phase 1 clinical trial, Intellia researchers injected a CRISPR therapy dubbed NTLA-2001 into the bloodstreams of six people with a rare, potentially fatal genetic disorder called transthyretin amyloidosis.
The livers of people with transthyretin amyloidosis produce a destructive protein, and the CRISPR therapy was designed to target the gene that makes the protein and halt its production. After just one injection of NTLA-2001, the three patients given a higher dose saw their levels of the protein drop by 80% to 96%.
A better option: The CRISPR therapy produced only mild adverse effects and did lower the protein levels, but we don't know yet if the effect will be permanent. It'll also be a few months before we know if the therapy can alleviate the symptoms of transthyretin amyloidosis.
This is a wonderful day for the future of gene-editing as a medicine.
If everything goes as hoped, though, NTLA-2001 could one day offer a better treatment option for transthyretin amyloidosis than a currently approved medication, patisiran, which only reduces toxic protein levels by 81% and must be injected regularly.
Looking ahead: Even more exciting than NTLA-2001's potential impact on transthyretin amyloidosis, though, is the knowledge that we may be able to use CRISPR injections to treat other genetic disorders that are difficult to target directly, such as heart or brain diseases.
"This is a wonderful day for the future of gene-editing as a medicine," Fyodor Urnov, a UC Berkeley professor of genetics, who wasn't involved in the trial, told NPR. "We as a species are watching this remarkable new show called: our gene-edited future."