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Autopsies of COVID-19 patients reveal surprising effects of heart damage
The information could influence future treatments.

Medical staff members transport a patient to the ICU of Mater Dei hospital amid the coronavirus (COVID-19) pandemic on June 23, 2020 in Belo Horizonte, Brazil.
- LSU Health New Orleans pathologists conducted autopsies on 22 patients that died of the novel coronavirus.
- The team discovered that damage is not typical inflammation of the heart, as is common with myocarditis.
- These research findings could have implications in treating COVID-19.
Science is not an infallible truth waiting to be discovered, but the process of acquiring knowledge through experimentation, observation, and confirmation. The fact that science—in the case of the novel coronavirus pandemic, medicine—is beholden to the whims of breaking news cycles sets us back. Medicine should be not be politicized, but we can't escape who we are.
We can become better, however, which is why the scientific process is valuable. A novel virus is just that: "new or unusual in an interesting way." COVID-19 is new, and while we've labeled it a respiratory virus, researchers recognize there's more going on. A lot more.
Take this new Research Letter on a series of 22 autopsies focused on heart damage caused by COVID-19. Conducted by LSU Health New Orleans pathologists and published in the journal, "Circulation," the researchers discovered that the heart damage is not typical inflammation, as is common with myocarditis.
Instead, the pathologists found a unique pattern of cell death in a number of heart muscle cells. This pattern differs from the first SARS coronavirus. Richard Vander Heide, professor and director of Pathology Research at LSU Health New Orleans School of Medicine and corresponding author of the Research Letter, says that while COVID-19 is similar to SARS in some ways, their findings reveal important distinctions that could affect future treatments.
Medical staff members wearing personal protective equipment (PPE) walks near a patient at Parque dos Atletas (Athlete's Village) field hospital amidst the coronavirus (COVID-19) pandemic on June 8, 2020 in Rio de Janeiro, Brazil.
Photo by Buda Mendes/Getty Images
An earlier report by the team found that patents suffered from diffuse alveolar damage, which affects "the small airspaces of the lung where gas exchange occurs." Blood clots and bleeding in blood vessels in the lungs, alongside severely enlarged right ventricles, were the major causes of death.
The age range of the patients was 44 to 79, with a median age of 68.5. Ten male and a dozen female patients were autopsied, 19 of whom were African-American. All suffered from pre-existing conditions: 18 had hypertension; nine were obese; half suffered from type 2 diabetes; and four had chronic kidney disease. While 18 of these patients were intubated, all died of respiratory failure.
The exact mechanism of cardiac injury from COVID-19 remains unknown. As the team writes in the Research Letter, these autopsies are providing insight into that process.
"Given that inflammatory cells can pass through the heart without being present in the tissue proper, a role for cytokine-induced endothelial damage cannot be ruled out."
Members of the LSU team are not the only researchers to discover viral infection of the endothelium, which might be the trigger for the cytokine storm.
Until the development of a vaccine, which may be some time off (and may never happen), or until more successful treatments are discovered, we'll have to settle for incremental knowledge. Like COVID-19 itself, the research process is not beholden to a news cycle, but we can be thankful for small gains in our understanding of this virus.
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Stay in touch with Derek on Twitter, Facebook and Substack. His next book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."
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‘Designer baby’ book trilogy explores the moral dilemmas humans may soon create
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
Tribalism and discrimination
<p>One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.</p><p>"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."</p><p>For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product." </p><p>Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with. </p><p>Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate? </p>Sexuality dilemmas
<p>Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.</p><p>But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.</p><p>But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image. </p><p>When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc. </p><p>Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.</p><p>"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.</p><p>But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme. </p>Regulating designer babies
<p>On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.</p><p>In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough." </p><p>After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations <a href="https://www.uvm.edu/~lkaelber/eugenics/" target="_blank">into the 1970s</a>). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century. </p><p>Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">illegal to implant a genetically modified embryo</a>. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies. </p><p>But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits. </p><p>If the industry did that, it'd effectively signal that the <em>opposites of those traits are undesirable. </em>As the International Bioethics Committee <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">wrote</a>, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."</p><p><em>"Genetic Pressure Volume I: Baby Steps"</em><em> by Eugene Clark is <a href="http://bigth.ink/38VhJn3" target="_blank">available now.</a></em></p>Massive 'Darth Vader' isopod found lurking in the Indian Ocean
The father of all giant sea bugs was recently discovered off the coast of Java.
A close up of Bathynomus raksasa
- A new species of isopod with a resemblance to a certain Sith lord was just discovered.
- It is the first known giant isopod from the Indian Ocean.
- The finding extends the list of giant isopods even further.
The ocean depths are home to many creatures that some consider to be unnatural.
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzU2NzY4My9vcmlnaW4ucG5nIiwiZXhwaXJlc19hdCI6MTYxNTUwMzg0NX0.BTK3zVeXxoduyvXfsvp4QH40_9POsrgca_W5CQpjVtw/img.png?width=980" id="b6fb0" class="rm-shortcode" data-rm-shortcode-id="2739ec50d9f9a3bd0058f937b6d447ac" data-rm-shortcode-name="rebelmouse-image" data-width="1512" data-height="2224" />Bathynomus raksasa specimen (left) next to a closely related supergiant isopod, B. giganteus (right)
<p>According to<a href="https://www.livescience.com/supergiant-isopod-newfound-species.html" target="_blank" rel="dofollow"> LiveScience</a>, the Bathynomus genus is sometimes referred to as "Darth Vader of the Seas" because the crustaceans are shaped like the character's menacing helmet. Deemed Bathynomus raksasa ("raksasa" meaning "giant" in Indonesian), this cockroach-like creature can grow to over 30 cm (12 inches). It is one of several known species of giant ocean-going isopod. Like the other members of its order, it has compound eyes, seven body segments, two pairs of antennae, and four sets of <a href="https://www.livescience.com/supergiant-isopod-newfound-species.html" target="_blank" rel="noopener noreferrer dofollow">jaws</a>.</p><p>The incredible size of this species is likely a result of deep-sea gigantism. This is the tendency for creatures that inhabit deeper parts of the ocean to be much larger than closely related species that live in shallower waters. B. raksasa appears to make its home between 950 and 1,260 meters (3,117 and 4,134 ft) below sea <a href="https://news.nus.edu.sg/research/new-species-supergiant-isopod-uncovered" target="_blank" rel="noopener noreferrer dofollow">level</a>. </p><p>Perhaps fittingly for a creature so creepy looking, that is the lower sections of what is commonly called <a href="https://en.wikipedia.org/wiki/Mesopelagic_zone" target="_blank" rel="noopener noreferrer dofollow">The Twilight Zone</a><em>, </em>named for the lack of light available at such depths. </p><p>It isn't the only giant isopod, <a href="https://en.wikipedia.org/wiki/Giant_isopod" target="_blank">far from it</a>. Other species of ocean-going isopod can get up to 50 cm long (20 inches) and also look like they came out of a nightmare. These are the unusual ones, though. Most of the time, isopods stay at much more reasonable <a href="https://indianexpress.com/article/explained/explained-raksasa-cockroach-from-the-deep-the-stuff-nightmares-are-made-of-6513281/" target="_blank" rel="noopener noreferrer dofollow">sizes</a>. </p><p>The discovery of this new species was published in <a href="https://zookeys.pensoft.net/article/53906/" target="_blank" rel="noopener noreferrer dofollow">ZooKeys</a>. The remainder of the specimens from the trip are still being analyzed. The full report will be published <a href="https://www.futurity.org/deep-sea-giant-isopod-bathynomus-raksasa-2422042/" target="_blank" rel="noopener noreferrer dofollow">shortly</a>.<em> </em></p>What benefit does this find have for science? And is it as evil as it looks?
<div class="rm-shortcode" data-media_id="7XqcvwWp" data-player_id="FvQKszTI" data-rm-shortcode-id="8506fcd195866131efb93525ae42dec4"> <div id="botr_7XqcvwWp_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/7XqcvwWp-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/7XqcvwWp-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/7XqcvwWp-FvQKszTI.js"></script> </div> <p>The discovery of a new species is always a cause for celebration in zoology. That this is the discovery of an animal that inhabits the deeps of the sea, one of the least explored areas humans can get to, is the icing on the cake.</p><p>Helen Wong of the National University of Singapore, who co-authored the species' description, explained the importance of the discovery:</p><p>"The identification of this new species is an indication of just how little we know about the oceans. There is certainly more for us to explore in terms of biodiversity in the deep sea of our region." </p><p>The animal's visual similarity to Darth Vader is a result of its compound eyes and the curious shape of its <a href="https://lkcnhm.nus.edu.sg/research/sjades2018/" target="_blank" rel="noopener noreferrer dofollow" style="">head</a>. However, given the location of its discovery, the bottom of the remote seas, it may be associated with all manner of horrifically evil Elder Things and <a href="https://en.wikipedia.org/wiki/Cthulhu" target="_blank" rel="dofollow">Great Old Ones</a>. <em></em></p>These are the world’s greatest threats in 2021
We look back at a year ravaged by a global pandemic, economic downturn, political turmoil and the ever-worsening climate crisis.
Billions are at risk of missing out on the digital leap forward, as growing disparities challenge the social fabric.
Image: Global Risks Report 2021
<h3>Widespread effects</h3><p>"The immediate human and economic costs of COVID-19 are severe," the report says. "They threaten to scale back years of progress on reducing global poverty and inequality and further damage social cohesion and global cooperation."</p><p>For those reasons, the pandemic demonstrates why infectious diseases hits the top of the impact list. Not only has COVID-19 led to widespread loss of life, it is holding back economic development in some of the poorest parts of the world, while amplifying wealth inequalities across the globe.</p><p>At the same time, there are concerns the fight against the pandemic is taking resources away from other critical health challenges - including a <a href="https://www.weforum.org/agenda/2020/09/charts-covid19-malnutrition-educaion-mental-health-children-world/" target="_blank" rel="noopener noreferrer">disruption to measles vaccination programmes</a>.</p>Columbia study finds new way to extract energy from black holes
A new study explains how a chaotic region just outside a black hole's event horizon might provide a virtually endless supply of energy.
- In 1969, the physicist Roger Penrose first proposed a way in which it might be possible to extract energy from a black hole.
- A new study builds upon similar ideas to describe how chaotic magnetic activity in the ergosphere of a black hole may produce vast amounts of energy, which could potentially be harvested.
- The findings suggest that, in the very distant future, it may be possible for a civilization to survive by harnessing the energy of a black hole rather than a star.
The ergosphere
<p>The ergosphere is a region just outside a black hole's event horizon, the boundary of a black hole beyond which nothing, not even light, can escape. But light and matter just outside the event horizon, in the ergosphere, would also be affected by the immense gravity of the black hole. Objects in this zone would spin in the same direction as the black hole at incredibly fast speeds, similar to objects floating around the center of a whirlpool.</p><p>The Penrose process states, in simple terms, that an object could enter the ergosphere and break into two pieces. One piece would head toward the event horizon, swallowed by the black hole. But if the other piece managed to escape the ergosphere, it could emerge with more energy than it entered with.</p><p>The movie "Interstellar" provides an example of the Penrose process. Facing a fuel shortage on a deep-space mission, the crew makes a last-ditch effort to return home by entering the ergosphere of a blackhole, ditching part of their spacecraft, and "slingshotting" away from the black hole with vast amounts of energy.</p><p>In a recent study published in the American Physical Society's <a href="https://journals.aps.org/prd/abstract/10.1103/PhysRevD.103.023014" target="_blank" style="">Physical Review D</a><em>, </em>physicists Luca Comisso and Felipe A. Asenjo used similar ideas to describe another way energy could be extracted from a black hole. The idea centers on the magnetic fields of black holes.</p><p style="margin-left: 20px;">"Black holes are commonly surrounded by a hot 'soup' of plasma particles that carry a magnetic field," Comisso, a research scientist at Columbia University and lead study author, told <a href="https://news.columbia.edu/energy-particles-magnetic-fields-black-holes" target="_blank" rel="noopener noreferrer">Columbia News</a>.</p>Ergosphere representation
<p>In the ergosphere of a rotating black hole, magnetic field lines are constantly breaking and reconnecting at fast speeds. The researchers theorized that when these lines reconnect, plasma particles shoot out in two different directions. One flow of particles shoots off against the direction of the spinning black hole, eventually getting "swallowed" by the black hole. But the other flow shoots in the same direction as the spin, potentially gaining enough velocity to escape the black hole's gravitational pull.</p><p>The researchers proposed that this occurs because the breaking and reconnecting of magnetic field lines can generate negative-energy particles. If the negative-energy particles get "swallowed" by the black hole, the positive particles would theoretically be exponentially accelerated.</p><p style="margin-left: 20px;">"Our theory shows that when magnetic field lines disconnect and reconnect, in just the right way, they can accelerate plasma particles to negative energies and large amounts of black hole energy can be extracted," Comisso said. "It is like a person could lose weight by eating candy with negative calories."</p>Black hole
Event Horizon Telescope Collaboration
<p>While there might not be immediate applications for the theory, it could help scientists better understand and observe black holes. On an abstract level, the findings may expand the limits of what scientists imagine is possible in deep space.</p><p style="margin-left: 20px;">"Thousands or millions of years from now, humanity might be able to survive around a black hole without harnessing energy from stars," Comisso said. "It is essentially a technological problem. If we look at the physics, there is nothing that prevents it."</p>A psychiatric diagnosis can be more than an unkind ‘label’
A popular and longstanding wave of thought in psychology and psychotherapy is that diagnosis is not relevant for practitioners in those fields.
