New study identifies 126 species that could host coronavirus

The study suggests scientists are underestimating the number of animal species that could generate the next novel coronavirus.

New study identifies 126 species that could host coronavirus
Credit: Pixabay
  • The novel coronavirus that causes COVID-19 is a product of different coronaviruses recombining in animal species.
  • A new study suggests that hundreds of animal species may harbor multiple types of coronaviruses, meaning recombination events could be more likely than previously thought.
  • The authors noted that their results could help improve surveillance programs to mitigate the risks associated with a future novel coronavirus.

A new study highlights hundreds of mammal species that could contract multiple coronaviruses, including SARS-CoV-2, and therefore become sources of new coronaviruses. Published in Nature Communications, the research suggests that novel coronaviruses could emerge from many more animal species than scientists have so far observed.

Coronaviruses comprise a large family of viruses. Humans are known to contract only seven coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2, all of which can cause severe disease or death. But coronaviruses can circulate more widely in the animal kingdom, and within it scientists have identified hundreds of unique strains.

Some animals can become infected with multiple coronaviruses at the same time. When this occurs, genes from the different viruses can combine and replicate, creating a novel coronavirus. This natural process is called recombination, and it's what produced SARS-CoV-2, the novel coronavirus that causes COVID-19.

So, in which animal species might the next novel coronavirus originate through recombination?


Wardeh et al.

Predicted hosts are grouped by order (inner circle). Middle circle presents probability of association between host and SARS-CoV-2 (grey scale indicates predicted associations with probability in range > 0.5 to ≤0.75. Red scale indicates predicted associations with probability in range > 0.75 to <0.9821. Blue to purple scale present indicates associations with probability ≥ 0.9821). Yellow bars represent number of coronaviruses (species or strains) observed to be found in each host. Blue stacked bars represent other coronaviruses predicted to be found in each host by our model. Predicted coronaviruses per host are grouped by prediction probability into three categories (from inside to outside): ≥0.9821, >0.75 to <0.9821 and >0.5 to ≤0.75.

To answer that, the researchers behind the recent study created a computer model to predict which species have the highest risk of being "reservoirs" for coronaviruses. Using data from GenBank, a National Institutes of Health database, the team compared 411 coronaviruses with 876 mammalian species that are known to contract coronaviruses.

The model predicted that each coronavirus species can infect, on average, more than 12 types of mammalian hosts. Meanwhile, the results suggested that each mammalian host can contract roughly five different types of coronavirus.

In terms of recombination, some mammalian species pose outsized threats. The study noted that the domestic pig presents a high risk because it is known to harbor many diverse coronaviruses.

"Given the large number of predicted viral associations presented here, the pig's close association to humans, its known reservoir status for many other zoonotic viruses, and its involvement in genetic recombination of some of these viruses, the pig is predicted to be one of the foremost candidates an important recombination host," the authors wrote.

Credit: Pixabay

The study also identified species in which SARS-CoV-2 might combine with other coronaviruses. These included the lesser Asiatic yellow bat, the common hedgehog, the European rabbit, chimpanzees, the African green monkey and domestic cats (which are already known to contract SARS-CoV-2, though there's no evidence that cats or other pets can spread the novel coronavirus to humans).

Also on that list was the dromedary camel, a "known host of multiple coronaviruses and the primary route of transmission of MERS-CoV to humans." It'd be especially concerning if MERS-CoV and SARS-CoV-2 recombined, considering the former is highly deadly and the latter is highly contagious.

Improved surveillance programs

Still, many factors must align for coronaviruses to merge and generate a novel coronavirus, and just because an animal is vulnerable to multiple viruses doesn't mean those viruses will recombine. But the team behind the study noted that scientists are likely underestimating the number of animals that could generate novel coronaviruses, and that the results can help inform surveillance programs for at-risk species.

"Such information could help inform prevention and mitigation strategies and provide a vital early warning system for future novel coronaviruses," the authors wrote.

How tiny bioelectronic implants may someday replace pharmaceutical drugs

Scientists are using bioelectronic medicine to treat inflammatory diseases, an approach that capitalizes on the ancient "hardwiring" of the nervous system.

Left: The vagus nerve, the body's longest cranial nerve. Right: Vagus nerve stimulation implant by SetPoint Medical.

Credit: Adobe Stock / SetPoint Medical
Sponsored by Northwell Health
  • Bioelectronic medicine is an emerging field that focuses on manipulating the nervous system to treat diseases.
  • Clinical studies show that using electronic devices to stimulate the vagus nerve is effective at treating inflammatory diseases like rheumatoid arthritis.
  • Although it's not yet approved by the US Food and Drug Administration, vagus nerve stimulation may also prove effective at treating other diseases like cancer, diabetes and depression.
Keep reading Show less

Just how cold was the Ice Age? New study finds the temperature

Researchers figure out the average temperatures of the last ice age on Earth.

Icebergs.

Credit: Pixabay
Surprising Science
  • A new study analyzes fossil data to find the average temperatures during the last Ice Age.
  • This period of time, about 20,000 years ago, had the average temperature of about 46 degrees Fahrenheit (7.8 C).
  • The study has implications for understanding climate change.

Keep reading Show less

Best. Science. Fiction. Show. Ever.

"The Expanse" is the best vision I've ever seen of a space-faring future that may be just a few generations away.

Credit: "The Expanse" / Syfy
13-8
  • Want three reasons why that headline is justified? Characters and acting, universe building, and science.
  • For those who don't know, "The Expanse" is a series that's run on SyFy and Amazon Prime set about 200 years in the future in a mostly settled solar system with three waring factions: Earth, Mars, and Belters.
  • No other show I know of manages to use real science so adeptly in the service of its story and its grand universe building.
Keep reading Show less

How exercise changes your brain biology and protects your mental health

Contrary to what some might think, the brain is a very plastic organ.

PRAKASH MATHEMA/AFP via Getty Images
Mind & Brain

As with many other physicians, recommending physical activity to patients was just a doctor chore for me – until a few years ago. That was because I myself was not very active.

Keep reading Show less
Surprising Science

Here's a 10-step plan to save our oceans

By 2050, there may be more plastic than fish in the sea.

Quantcast