Confessions of an Outlaw: A Creativity Workshop, with Philippe Petit

Confessions of an Outlaw: A Creativity Workshop, with Philippe Petit

High-wire artist Philippe Petit, who four decades ago performed illegally between the World Trade Center towers, explains how his personal brand of outlaw creativity can be harnessed to inspire and solve problems.

Confessions of an Outlaw: The Self You Bring

How to you inspire people? How do you touch an audience? High-wire artist Philippe Petit explains that the secret is to not try at all. Instead, be yourself. Follow your own personal muses instead of being a crowd pleaser. Genuine individual creativity is endearing enough on its own that if your passion emerges through your work, your audience will be reached.

This is the first video in a nine-part series with Philippe Petit available in playlist form here.

Confessions of an Outlaw: Chaos and Order

High-wire artist Philippe Petit describes his process of compressing chaos in order to build a model for creative output. When faced with a long list of goals and subjects for a creative endeavor, make a list. Introduce order. Compartmentalize your thoughts and ambitions. The key is to find the precise marriage between madness and structure.

Confessions of an Outlaw: The Alchemy of Sleep

High-wire artist Philippe Petit explains how he practices creativity while sleeping. If he falls asleep with an idea in his head, Petit allows his subconscious self the opportunity to find a solution. Often he wakes up with the solution sitting there waiting for him.

Confessions of an Outlaw: Finding Focus

High-wire artist Philippe Petit doesn't own a cellphone, doesn't own jewelry, doesn't wear a watch. These are all distractions that would draw his focus away from his art. And when you're walking a wire and a millisecond's loss of focus results in tragedy, perhaps eschewing gadgetry is the way to go.

Petit explains how an occasional foray into being a Luddite will allow you to reconnect with your raw humanity.

Confessions of an Outlaw: Discipline and Play

A marriage of discipline and play seems contradictory, but Philippe Petit says he thrives on being an extreme and contradictory artist. The high-wire artist explains why being a successful artist requires a marriage of extremes. You have to work hard and play hard. There is no sacrificing either.

This is the fifth video in a nine-part series with Philippe Petit available in playlist form here.

Confessions of an Outlaw: The Art of Balance

High-wire artist Philippe Petit wasn't just born with superior balance; it's something he's developed all his life and something he applies to all his life. It's balance -- in more meanings of the word -- which keeps Petit alive.

Confessions of an Outlaw: Intuition and Improvisation

High-wire artist Philippe Petit explains that intuition and improvisation are not opposites. They are cousins. One must take an intellectual approach to an adventurous exploration of the unknown.

Confessions of an Outlaw: Valuable Mistakes

As a high-wire artist, Philippe Petit doesn't have much room for mistakes. Still, he finds that mistakes are our best teachers and advises friends and students to treat them as such.

This is the ninth video in a nine-part series with Philippe Petit available in playlist form here.

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The U.S. Food and Drug Administration requires all new medicines to be tested in animals before use in people. Pigs make better medical research subjects than mice, because they are closer to humans in size, physiology and genetic makeup.

In recent years, our team at Iowa State University has found a way to make pigs an even closer stand-in for humans. We have successfully transferred components of the human immune system into pigs that lack a functional immune system. This breakthrough has the potential to accelerate medical research in many areas, including virus and vaccine research, as well as cancer and stem cell therapeutics.

Existing biomedical models

Severe Combined Immunodeficiency, or SCID, is a genetic condition that causes impaired development of the immune system. People can develop SCID, as dramatized in the 1976 movieThe Boy in the Plastic Bubble." Other animals can develop SCID, too, including mice.

Researchers in the 1980s recognized that SCID mice could be implanted with human immune cells for further study. Such mice are called “humanized" mice and have been optimized over the past 30 years to study many questions relevant to human health.

Mice are the most commonly used animal in biomedical research, but results from mice often do not translate well to human responses, thanks to differences in metabolism, size and divergent cell functions compared with people.

Nonhuman primates are also used for medical research and are certainly closer stand-ins for humans. But using them for this purpose raises numerous ethical considerations. With these concerns in mind, the National Institutes of Health retired most of its chimpanzees from biomedical research in 2013.

Alternative animal models are in demand.

Swine are a viable option for medical research because of their similarities to humans. And with their widespread commercial use, pigs are met with fewer ethical dilemmas than primates. Upwards of 100 million hogs are slaughtered each year for food in the U.S.

Humanizing pigs

In 2012, groups at Iowa State University and Kansas State University, including Jack Dekkers, an expert in animal breeding and genetics, and Raymond Rowland, a specialist in animal diseases, serendipitously discovered a naturally occurring genetic mutation in pigs that caused SCID. We wondered if we could develop these pigs to create a new biomedical model.

Our group has worked for nearly a decade developing and optimizing SCID pigs for applications in biomedical research. In 2018, we achieved a twofold milestone when working with animal physiologist Jason Ross and his lab. Together we developed a more immunocompromised pig than the original SCID pig – and successfully humanized it, by transferring cultured human immune stem cells into the livers of developing piglets.

During early fetal development, immune cells develop within the liver, providing an opportunity to introduce human cells. We inject human immune stem cells into fetal pig livers using ultrasound imaging as a guide. As the pig fetus develops, the injected human immune stem cells begin to differentiate – or change into other kinds of cells – and spread through the pig's body. Once SCID piglets are born, we can detect human immune cells in their blood, liver, spleen and thymus gland. This humanization is what makes them so valuable for testing new medical treatments.

We have found that human ovarian tumors survive and grow in SCID pigs, giving us an opportunity to study ovarian cancer in a new way. Similarly, because human skin survives on SCID pigs, scientists may be able to develop new treatments for skin burns. Other research possibilities are numerous.

An indoor space housing pigs, with specialize air vents and plastic sheeting.

The ultraclean SCID pig biocontainment facility in Ames, Iowa. Adeline Boettcher, CC BY-SA

Pigs in a bubble

Since our pigs lack essential components of their immune system, they are extremely susceptible to infection and require special housing to help reduce exposure to pathogens.

SCID pigs are raised in bubble biocontainment facilities. Positive pressure rooms, which maintain a higher air pressure than the surrounding environment to keep pathogens out, are coupled with highly filtered air and water. All personnel are required to wear full personal protective equipment. We typically have anywhere from two to 15 SCID pigs and breeding animals at a given time. (Our breeding animals do not have SCID, but they are genetic carriers of the mutation, so their offspring may have SCID.)

As with any animal research, ethical considerations are always front and center. All our protocols are approved by Iowa State University's Institutional Animal Care and Use Committee and are in accordance with The National Institutes of Health's Guide for the Care and Use of Laboratory Animals.

Every day, twice a day, our pigs are checked by expert caretakers who monitor their health status and provide engagement. We have veterinarians on call. If any pigs fall ill, and drug or antibiotic intervention does not improve their condition, the animals are humanely euthanized.

Our goal is to continue optimizing our humanized SCID pigs so they can be more readily available for stem cell therapy testing, as well as research in other areas, including cancer. We hope the development of the SCID pig model will pave the way for advancements in therapeutic testing, with the long-term goal of improving human patient outcomes.

Adeline Boettcher earned her research-based Ph.D. working on the SCID project in 2019.The Conversation

Christopher Tuggle, Professor of Animal Science, Iowa State University and Adeline Boettcher, Technical Writer II, Iowa State University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

  • A recent study used data collected by NASA satellites to conduct a statistical analysis of surface temperatures near volcanoes that erupted from 2002 to 2019.
  • The results showed that surface temperatures near volcanoes gradually increased in the months and years prior to eruptions.
  • The method was able to detect potential eruptions that were not anticipated by other volcano monitoring methods, such as eruptions in Japan in 2014 and Chile in 2015.

How can modern technology help warn us of impending volcanic eruptions?

One promising answer may lie in satellite imagery. In a recent study published in Nature Geoscience, researchers used infrared data collected by NASA satellites to study the conditions near volcanoes in the months and years before they erupted.

The results revealed a pattern: Prior to eruptions, an unusually large amount of heat had been escaping through soil near volcanoes. This diffusion of subterranean heat — which is a byproduct of "large-scale thermal unrest" — could potentially represent a warning sign of future eruptions.

large-scale thermal unrest Conceptual model of large-scale thermal unrestCredit: Girona et al.

For the study, the researchers conducted a statistical analysis of changes in surface temperature near volcanoes, using data collected over 16.5 years by NASA's Terra and Aqua satellites. The results showed that eruptions tended to occur around the time when surface temperatures near the volcanoes peaked.

Eruptions were preceded by "subtle but significant long-term (years), large-scale (tens of square kilometres) increases in their radiant heat flux (up to ~1 °C in median radiant temperature)," the researchers wrote. After eruptions, surface temperatures reliably decreased, though the cool-down period took longer for bigger eruptions.

"Volcanoes can experience thermal unrest for several years before eruption," the researchers wrote. "This thermal unrest is dominated by a large-scale phenomenon operating over extensive areas of volcanic edifices, can be an early indicator of volcanic reactivation, can increase prior to different types of eruption and can be tracked through a statistical analysis of little-processed (that is, radiance or radiant temperature) satellite-based remote sensing data with high temporal resolution."

Temporal variations of target volcanoes Temporal variations of target volcanoesCredit: Girona et al.

Although using satellites to monitor thermal unrest wouldn't enable scientists to make hyper-specific eruption predictions (like predicting the exact day), it could significantly improve prediction efforts. Seismologists and volcanologists currently use a range of techniques to forecast eruptions, including monitoring for gas emissions, ground deformation, and changes to nearby water channels, to name a few.

Still, none of these techniques have proven completely reliable, both because of the science and the practical barriers (e.g. funding) standing in the way of large-scale monitoring. In 2014, for example, Japan's Mount Ontake suddenly erupted, killing 63 people. It was the nation's deadliest eruption in nearly a century.

In the study, the researchers found that surface temperatures near Mount Ontake had been increasing in the two years prior to the eruption. To date, no other monitoring method has detected "well-defined" warning signs for the 2014 disaster, the researchers noted.

The researchers hope satellite-based infrared monitoring techniques, combined with existing methods, can improve prediction efforts for volcanic eruptions. Volcanic eruptions have killed about 2,000 people since 2000.

"Our findings can open new horizons to better constrain magma–hydrothermal interaction processes, especially when integrated with other datasets, allowing us to explore the thermal budget of volcanoes and anticipate eruptions that are very difficult to forecast through other geophysical/geochemical methods."

    • A new essay compares the power-up system in Mario Kart to feedback loops in real-life systems.
    • Both try to provide targeted benefits to those who most need them.
    • While games are simpler than reality, Mario's example makes the real-life cases easier to understand.

      Poverty can be a self-sustaining cycle that might require an external influence to break it. A new paper published in Nature Sustainability and written by professor Andrew Bell of Boston University suggests that we could improve global anti-poverty and economic development systems by turning to an idea in a video game about a race car-driving Italian plumber.

      A primer on Mario Kart

      For those who have not played it, Mario Kart is a racing game starring Super Mario and other characters from the video game franchise that bears his name. Players race around tracks collecting power-ups that can directly help them, such as mushrooms that speed up their karts, or slow down other players, such as heat-seeking turtle shells that momentarily crash other karts.

      The game is well known for having a mechanism known as "rubber-banding." Racers in the front of the pack get wimpy power-ups, like banana peels to slip up other karts, while those toward the back get stronger ones, like golden mushrooms that provide extra long speed boosts. The effect of this is that those in the back are pushed towards the center, and those in front don't get any boosts that would make catching them impossible.

      If you're in last, you might get the help you need to make a last-minute break for the lead. If you're in first, you have to be on the lookout for these breakouts (and the ever-dreaded blue shells). The game remains competitive and fun.

      Rubber-banding: A moral and economic lesson from Mario Kart

      In the real world, we see rubber-banding used all the time. Welfare systems tend to provide more aid to those who need it than those who do not. Many of them are financed by progressive taxation, which is heavier on the well-off than the down-and-out. Some research suggests that these do work, as countries with lower levels of income inequality have higher social mobility levels.

      It is a little more difficult to use rubber-banding in real life than in a video game, of course. While in the game, it is easy to decide who is doing well and who is not, things can be a little more muddled in reality. Furthermore, while those in a racing game are necessarily antagonistic to each other, real systems often strive to improve conditions for everybody or to reach common goals.

      As Bell points out, rubber-banding can also be used to encourage sustainable, growth programs that help the poor other than welfare. They point out projects such as irrigation systems in Pakistan or Payments for Ecosystems Services (PES) schemes in Malawi, which utilize positive feedback loops to both provide aid to the poor and promote stable systems that benefit everyone.

      Rubber-banding feedback loops in different systems. Mario Kart (a), irrigation systems in Pakistan (b), and PES operations in Malawi (c) are shown. Links between one better-off (blue) and one worse-off (red) individual are highlighted. Feedback in Mario Kart (a), designed to balance the racers, imprAndrew Bell/ Nature Sustainability

      In the Malawi case, farmers were paid to practice conservation agriculture to reduce the amount of sediment from their farms flowing into a river. This immediately benefits hydroelectric producers and their customers but also provides real benefits to farmers in the long run as their soil doesn't erode. By providing an incentive to the farmers to conserve the soil, a virtuous cycle of conservation, soil improvement, and improved yields can begin.

      While this loop differs from the rubber-banding in Mario, the game's approach can help illustrate the benefits of rubber-banding in achieving a more equitable world.

      The task now, as Bell says in his paper, is to look at problems that exist and find out "what the golden mushroom might be."

      • A new study found that women with elevated stress before, during, and after conception are twice as likely to deliver a girl.
      • One factor could be that sperm carrying an X chromosome are better equipped to reach the egg under adverse conditions.
      • Another factor could be miscarriage of male fetuses during times of stress.

        Stress in the modern world is generally viewed as a hindrance to a healthy life.

        Indeed, excess stress is associated with numerous problems, including cardiovascular disease, high blood pressure, insomnia, depression, obesity, and other conditions. While the physiological mechanisms associated with stress can be beneficial, as Kelly McGonigal points out in The Upside of Stress, the modern wellness industry is built on the foundation of stress relief.

        The effects of stress on pregnant mothers is another longstanding area of research. For example, what potential negative effects do elevated levels of cortisol, epinephrine, and norepinephrine have on fetal development?

        A new study, published in the Journal of Developmental Origins of Health and Disease, investigated a very specific aspect of stress on fetuses: does it affect sex? Their findings reveal that women with elevated stress are twice as likely to give birth to a girl.

        For this research, the University of Granada scientists recorded the stress levels of 108 women before, during, and after conception. By testing cortisol concentration in their hair and subjecting the women to a variety of psychological tests, the researchers discovered that stress indeed influences sex. Specifically, stress made women twice as likely to deliver a baby girl.

        The team points out that their research is consistent with other research that used saliva to show that stress resulted in a decreased likelihood of delivering a boy.

        Maria Isabel Peralta RamírezPhoto courtesy of University of Granada

        Lead author María Isabel Peralta Ramírez, a researcher at the UGR's Department of Personality, Evaluation and Psychological Treatment, says that prior research focused on stress levels leading up to and after birth. She was interested in stress's impact leading up to conception. She says:

        "Specifically, our research group has shown in numerous publications how psychological stress in the mother generates a greater number of psychopathological symptoms during pregnancy: postpartum depression, a greater likelihood of assisted delivery, an increase in the time taken for lactation to commence (lactogenesis), or inferior neurodevelopment of the baby six months after birth."

        While no conclusive evidence has been rendered, the research team believes that activation of the mother's endogenous stress system during conception sets the concentration of sex hormones that will be carried throughout development. As the team writes, "there is evidence that testosterone functions as a mechanism when determining the baby's sex, since the greater the prenatal stress levels, the higher the levels of female testosterone." Levels of paternal stress were not factored into this research.

        Previous studies show that sperm carrying an X chromosome are better equipped to reach the egg under adverse conditions than sperm carrying the Y chromosome. Y fetuses also mature slowly and are more likely to produce complications than X fetuses. Peralta also noted that there might be more aborted male fetuses during times of early maternal stress, which would favor more girls being born under such circumstances.

          In the future, Peralta and her team say an investigation into aborted fetuses should be undertaken. Right now, the research was limited to a small sample size that did not factor in a number of elements. Still, the team concludes, "the research presented here is pioneering to the extent that it links prenatal stress to the sex of newborns."


            Stay in touch with Derek on Twitter and Facebook. His most recent book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."

            • Conflict and violence cost the world more than $14 trillion a year.
            • That's the equivalent of $5 a day for every person on the planet.
            • Research shows that peace brings prosperity, lower inflation and more jobs.
            • Just a 2% reduction in conflict would free up as much money as the global aid budget.
            • Report urges governments to improve peacefulness, especially amid COVID-19.

            What is the price of peace?

            Or put another way, how much better off would we all be in a world where armed conflict was avoided?

            Around $14.4 trillion in 2019, according to the Institute for Economics and Peace (IEP) which crunched the numbers. That's about $5 a day for every person on the planet.

            To give some context, 689 million people - more than 9% of the world's population - live on less than $1.90 a day, according to World Bank figures, underscoring the potential impact peace-building activities could have.

            Just over 10% of global GDP is being spent on containing, preventing and dealing with the consequences of violence. As well as the 1.4 million violent deaths each year, conflict holds back economic development, causes instability, widens inequality and erodes human capital.

            Putting a price tag on peace and violence helps us see the disproportionately high amounts spent on creating and containing violent acts compared to what is spent on building resilient, productive, and peaceful societies.
            —Steve Killelea, founder and executive chairman, Institute for Economics & Peace (IEP)

            The cost of violence

            In a report titled "The Economic Value of Peace 2021", the IEP says that for every death from violent conflict, 40 times as many people are injured. The world's 10 most affected countries are spending up to 59% of their GDP on the effects of violence.

            Grounds for hope

            But the picture is not all bleak. The economic impact of violence fell for the second year in a row in 2019, as parts of the world became more peaceful.

            The global cost dropped by $64 billion between 2018 and 2019, even though it was still $1.2 trillion higher than in 2012.

            In five regions of the world the costs increased in 2019. The biggest jump was in Central America and the Caribbean, where a rising homicide rate pushed the cost up 8.3%.

            Syria, with its ongoing civil war, suffered the greatest economic impact with almost 60% of its GDP lost to conflict in 2019. That was followed by Afghanistan (50%) and South Sudan (46%).

            The report makes a direct link between peace and prosperity. It says that, since 2000, countries that have become more peaceful have averaged higher GDP growth than those which have become more violent.

            "This differential is significant and represents a GDP per capita that is 30% larger when compounded over a 20-year period," the report says adding that peaceful countries also have substantially lower inflation and unemployment.

            "Small improvements in peace can have substantial economic benefits," it adds. "For example, a 2% reduction in the global impact of violence is roughly equivalent to all overseas development aid in 2019."

            Equally, the total value of foreign direct investment globally only offsets 10% of the economic impact of violence. Authoritarian regimes lost on average 11% of GDP to the costs of violence while in democracies the cost was just 4% of GDP.

            And the gap has widened over time, with democracies reducing the cost of violence by almost 16% since 2007 while in authoritarian countries it has risen by 27% over the same period.

            The report uses 18 economic indicators to evaluate the cost of violence. The top three are military spending (which was $5.9 trillion globally in 2019), the cost of internal security which makes up over a third of the total at $4.9 trillion and homicide.

            Peace brings prosperity

            The formula also contains a multiplier effect because as peace increases, money spent containing violence can instead be used on more productive activities which drive growth and generate higher monetary and social returns.

            "Substantial economic improvements are linked to improvements in peace," says the report. "Therefore, government policies should be directed to improving peacefulness, especially in a COVID-19 environment where economic activity has been subdued."

            The IEP says what it terms "positive peace" is even more beneficial than "negative peace" which is simply the absence of violence or the fear of violence. Positive peace involves fostering the attitudes, institutions & structures that create and sustain peaceful societies.

            The foundations of a positively peaceful society, it says, are: a well functioning government, sound business environment, acceptance of the rights of others, good relations with neighbours, free flow of information, high levels of human capital, low levels of corruption and equitable distribution of resources.

            The World Economic Forum's report Mobilizing the Private Sector in Peace and Reconciliation urged companies large and small to recognise their potential to work for peace quoting the former Goldman Sachs chair, the late Peter Sutherland, who said: "Business thrives where society thrives."

            Reprinted with permission of the World Economic Forum. Read the original article.