Expect cancer treatment to be 'smarter'. 1) With cancer genomics, routinely identifying the molecular lesions in individual patients will allow patient-optimized treatment. How mutations interact and how patients with unique combinations respond requires extensive research. 2) The cancer stem cell concept. To 'cure' cancer target the few aberrant stem cells (the seeds of cancer) rather than blindly reducing tumor mass. Distinguishing normal from cancer stem cells is a research 'hot topic'