How Sound and Smell Cues Can Enhance Learning While You Sleep
Neuroscientists are now starting to put TMR to work.
My mother is one of five children, so she has plenty of stories about her and her siblings’ misadventures. One of my favourites revolves around my ‘weird’ Uncle Dorsey and his early scientific endeavours. When my mom was about eight years old, her older brother slipped a tape player under her bed every night to quietly play a reading of the poem ‘The Raven’ (1845) by Edgar Allan Poe. Night after night, he would play the tape, trying to test whether she would spontaneously recite the poem from all her exposure. The way she tells it, she woke up every time the recording started to play. Sure, she can still recite the first few lines, but only because she was awakened by the poem night after night.
My uncle never managed to get my mom to ‘sleep learn’, but it turns out that some of his ideas might not have been so misguided. While sleep-learning, also referred to as hypnopaedia, has been debunked, neuroscientists in my lab and others are now discovering ways to use stimuli such as sound cues during sleep to strengthen memories.
Early researchers made the same mistake as Uncle Dorsey, and thought that we could learn new material during sleep by osmosis, à la Aldous Huxley’s Brave New World (1932). Just as in the dystopian novel, experiments attempting this sleep-learning were often based on the false premise that sleep is like a hypnotic state. In the 1920s, some researchers believed that they could teach participants totally new information by playing audio recordings as they slept, and inventors began selling devices based on the idea. It wasn’t much different from the ‘Big Cheese’ (1996) episode of Dexter’s Laboratory, in which the cartoon boy-genius uses a massive gadget to try to teach himself French as he sleeps: it didn’t work.
It wasn’t until the 1950s that researchers discovered the touted effects of hypnopaedia were actually not due to sleep at all. Instead these contraptions were actually awakening people. The debunkers could tell by using a relatively established technique called electroencephalography (EEG), which records the brain’s electrical signals through electrodes placed on the scalp. Using EEG on their participants, researchers could tell that the sleep-learners were actually awake (something we still do in research today), and this all but ended research into sleep as a cognitive tool. 50 years later, we now know it is possible to alter memory during sleep, just in a different way than previously expected.
In 2007, the neuroscientist Björn Rasch at Lübeck University and colleagues reported that smells, which were associated with previously learned material, could be used to cue the sleeping brain. The study authors had taught participants the locations of objects on a grid, just like in the game Concentration, and exposed them to the odour of roses as they did so. Next, participants slept in the lab, and the experimenters waited until the deepest stage of sleep (slow-wave sleep) to once again expose them to the odour. Then when they were awake, the participants were significantly better at remembering where the objects were located. This worked only if they had been exposed to the rose odour during learning, and had smelled it during slow-wave sleep. If they were exposed to the odour only while awake or during REM sleep, the cue didn’t work.
It almost seemed too good to be true. Could we really ‘tag’ memories during learning with a smell and then persuade our brain to rehearse it during sleep? Multiple studies since the initial paper verified the finding, and there were even new variations such as using sound cues instead of odours.
At the cognitive neuroscience Paller Lab at Northwestern University where I work, multiple papers have been published demonstrating that neuroscientists can link a single sound to a single object and reactivate it individually. For example, you could play Concentration and learn that the cat is in the lower left corner, and the tea kettle is in the upper right. When you learn the cat, you hear a meow, and when you learn the kettle, you hear a whistle. Now, if during slow-wave sleep we were to play only one of those sounds such as the meow, you would actually remember the cat’s location even better than the kettle. Keep in mind, both of these items were initially learned equally well, showing that the sleep-cueing preferentially helped the cat. This ability to select specific memories to reactivate is called targeted memory reactivation (TMR).
We call it TMR because we believe that playing a sound cue like this reactivates the memory of learning the object’s location from the previous task. My lab believes this replay of the memory allows the brain to strengthen its memory representation, thus leading to better recall. Working with rats, the brain scientists Daniel Bendor and Matthew Wilson of the Massachusetts Institute of Technology found exactly this expected replay when they administered sound cues related to previous learning.
Henri Rousseau [Public domain], via Wikimedia Commons
Neuroscientists are now starting to put TMR to work. One recent study from my group operated a lot like the video game Guitar Hero, where the player takes centre stage as the musician. James Antony, now a postdoc at Princeton University but a graduate student at the time, had participants learn two musical sequences on a keyboard. The songs were composed of four notes, which appeared as falling circles, much like the actual game. After learning both songs equally well, participants took a nap, and Antony cued them with one of the songs. When they were retested after sleep, participants were better at the sleep-cued song than the uncued one. Think of how quickly you could learn a new musical instrument or song, just by reminding your sleeping brain of previous learning!
Though some translational research has started to surface, we still don’t know the boundaries of TMR or sleep-cueing in general. In a 2017 paper, the postdoctoral researcher Laura Batterink from my lab and colleagues found that TMR cueing in combination with REM sleep led to better recall of words that were cued during an afternoon nap. This research seems to point to REM sleep as a beneficial state when cued memories are integrated into preexisting memory networks.
Outstanding questions that we have yet to address include: does this work for foreign-language learning (ie, grammar learning), or just learning foreign vocabulary? Could it be used to help maintain memory performance in an ageing population? Does reactivating some memories mean that others are wiped away even more quickly?
I’m personally interested in how these reactivated memories might be changing due to these cues. My current projects are aimed at investigating whether cueing causes the whole memory to maintain detail or whether these cues might be consolidating the ‘gist’ of the memory and losing extraneous detail. Alternatively, TMR might help to boost all aspects of memory consolidation and show cognitive costs only for uncued items.
We have some hunches, and new projects to address these questions are cropping up all the time. But we’re still on the frontier of understanding the sleeping brain. For an activity that we do for about one third of our life, there are more questions than answers. Maybe weird Uncle Dorsey and his Poe tapes actually were prescient of the future of sleep research.
This article was originally published at Aeon and has been republished under Creative Commons.
Dominique Crenn, the only female chef in America with three Michelin stars, joins Big Think Live this Thursday at 1pm ET.
Astronomers spot an object heading into Earth orbit.
Minimoons<p>Scientists have confirmed just two prior minimoons. One was <a href="https://en.wikipedia.org/wiki/2006_RH120" target="_blank">2006 RH120</a>, which orbited us from September 2006 to June 2007. The other was <a href="https://en.wikipedia.org/wiki/2020_CD3" target="_blank">2020 CD3</a>, which got stuck in the 2015–2016 timeframe, and is believed to gotten away in May 2020.</p><p>2020 SO, the new kid on the block, is expected to arrive in October 2020 and pop out of orbit in May 2021.</p><div id="37962" class="rm-shortcode" data-rm-shortcode-id="f4c0fc8a2cba6536ea4cd960ebed3e6e"><blockquote class="twitter-tweet twitter-custom-tweet" data-twitter-tweet-id="1307729521869611008" data-partner="rebelmouse"><div style="margin:1em 0">Asteroid 2020 SO may get captured by Earth from Oct 2020 - May 2021. Current nominal trajectory shows shows capture… https://t.co/F5utxRvN6Z</div> — Tony Dunn (@Tony Dunn)<a href="https://twitter.com/tony873004/statuses/1307729521869611008">1600621989.0</a></blockquote></div>
Identifying 2020 SO<p>The first clue 2020 SO isn't your ordinary asteroid is its exceptionally low velocity. It's traveling much more slowly that a typical asteroid — their <a href="https://www.lpi.usra.edu/exploration/training/illustrations/craterMechanics/" target="_blank">average rate of travel</a> <a href="https://www.lpi.usra.edu/exploration/training/illustrations/craterMechanics/" target="_blank" rel="noopener noreferrer"></a>is 18 kilometers (58,000 feet) per second. Even <a href="https://en.wikipedia.org/wiki/Moon_rock" target="_blank">moon rocks</a> sent careening into Earth orbit by impacts on the lunar surface outpace pokey 2020 SO.</p><p>For another thing, 2020 SO has an orbital path very similar to Earth's, lasting about one Earth year. It's also just slightly less circular than our own orbit, from which it's barely tilted off-axis.</p><p>So, what is it? <a href="https://cneos.jpl.nasa.gov/ca/" target="_blank">NASA estimates</a> that the object has dimensions very reminiscent of a discarded Centaur rocket stage from the <a href="https://en.wikipedia.org/wiki/Surveyor_2" target="_blank" rel="noopener noreferrer">Surveyor 2 mission</a> that landed an unmanned craft on the moon. Back in the day, rocket stages were jettisoned as craft were aimed toward their desired position. This stuff, if released high enough, remains in space. It appears that this Centaur rocket, launched in September 1966, is now making its way back homeward, at least for a little bit.</p><p>When 2020 SO arrives at its closest point in December, the rocket is expected to be about 50,000 kilometers from Earth. Its next closest approach is much further: 220,000 kilometers, in February 2010.</p><img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQzMDk3NC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyODg1MTQ1MX0.HGknDwqp0GmeuczKY_AS7vrPG7KMFUc_XO95tNoI2xo/img.jpg?width=980" id="e5cda" class="rm-shortcode" data-rm-shortcode-id="85eb1f790d8c3ee5b261f7ba13eaa5e1" data-rm-shortcode-name="rebelmouse-image" alt="Centaur rocket stage" />
Centaur rocket stage
What we may be able to learn<p>Earthly space programs being as young as they are, scientists would love to know what's happened to our rocket during a half century in space.</p><p>While 2020 SO won't get close enough to drop into our atmosphere, its slow progress has scientists hopeful that they'll still get some kind of a decent look at it.</p><p>Spectroscopy may be able to reveal what the rocket's surface is like now — has any of its paint survived, for example? Of course, being out in space, it's likely to have been hit by lots of dust and micrometeorites, so the current state of its surfaces is also of interest. Experts are curious to know how reflective the rocket is at this point, valuable information that can help planners of future long-term missions anticipate how well a craft out in space for extended periods will remain able to reflect sunlight.</p>
The U.S., China, and Russia are in a "vaccine race" that treats a global challenge like a winner-take-all game.
All for one (vaccine)<p>Launched this April, <a href="https://www.who.int/initiatives/act-accelerator" target="_blank">the Access to COVID-19 Tools (ACT) Accelerator</a> brought together a panoply of governments, scientists, businesses, and global health organizations with the goal of accelerating the development, production, and distribution of an efficacious COVID-19 vaccine. The "vaccines pillar" of this initiative is <a href="https://www.gavi.org/vaccineswork/covax-explained" target="_blank">the COVAX Facility</a>.</p><p>COVAX is coordinated by the WHO, the Coalition for Epidemic Preparedness Innovations (CEPI), and Gavi, the Vaccine Alliance. The program maintains a diverse portfolio of COVID-10 vaccines, monitoring each to identify promising candidates. It has also partnered with manufacturers to ease investment risks and serves as a purchasing pool for self-financing countries, while offering fundraising efforts to poorer ones.</p><p>"[G]overnments from every continent have chosen to work together, not only to secure vaccines for their own populations, but also to help ensure that vaccines are available to the most vulnerable everywhere," Seth Berkley, CEO of Gavi, <a href="https://www.gavi.org/news/media-room/boost-global-response-covid-19-economies-worldwide-formally-sign-covax-facility" target="_blank">said in a release</a>. "With the commitments we're announcing today for the COVAX Facility, as well as the historic partnership we are forging with industry, we now stand a far better chance of ending the acute phase of this pandemic once safe, effective vaccines become available."</p><p><a href="https://www.vox.com/21448719/covid-19-vaccine-covax-who-gavi-cepi" target="_blank" rel="noopener noreferrer">In an interview with Vox</a>, Berkley noted that the ACT Accelerator is the largest global collaboration since the Paris Climate Agreement. He added, "This type of solidarity is critical because otherwise what you're going to end up with is just a constant reintroduction of infections and the inability to go back to normal."</p><p>As of Monday, 64 higher-income countries and 92 low- and middle-income countries—representing nearly two-thirds of the world's population—<a href="https://www.gavi.org/news/media-room/boost-global-response-covid-19-economies-worldwide-formally-sign-covax-facility" target="_blank" rel="noopener noreferrer">have signed commitments to COVAX</a>. Thirty-eight more are expected to sign soon.</p><p>COVAX's goal is to have 2 billion doses by the end of 2021. Experts estimate this amount will cover high-risk and vulnerable people, as well as healthcare workers, worldwide. Participating nations must cover those populations before administering vaccines according to national priorities. As part of the agreement, countries agree to support equal access to the vaccine once it becomes available, a move aimed at preventing hoarding and price gouging. </p><p>Currently, CEPI is supporting nine candidate vaccines, of which eight are in clinical trials.</p>
Why has the U.S. backed out?<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="7167e0bf1593a7cb29c1a116041116e3"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/LUAsKbH7yeY?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>The United States is gambling that its bilateral deals with various pharmaceutical companies will win the "<a href="https://www.washingtonpost.com/world/coronavirus-vaccine-trump/2020/09/01/b44b42be-e965-11ea-bf44-0d31c85838a5_story.html" target="_blank" rel="noopener noreferrer">vaccine race</a>." This U.S.-only initiative, named (sigh) <a href="https://www.hhs.gov/about/news/2020/06/16/fact-sheet-explaining-operation-warp-speed.html" target="_blank" rel="noopener noreferrer">Operation Warp Speed</a>, has already spent <a href="https://www.cnbc.com/2020/08/14/the-us-has-already-invested-billions-on-potential-coronavirus-vaccines-heres-where-the-deals-stand.html" target="_blank" rel="noopener noreferrer">approximately $10 billion</a> and is pushing to deliver 300 million doses by January 2021. Many experts worry this speedy push through the regulatory path could result in <a href="https://www.sciencemag.org/news/2020/08/here-s-how-us-could-release-covid-19-vaccine-election-and-why-scares-some" target="_blank" rel="noopener noreferrer">premature and dangerous approvals</a>.</p><p>China and Russia have likewise bet on their own high-priced ponies. Russia is touting <a href="https://arstechnica.com/science/2020/09/russia-offers-its-untested-covid-19-vaccine-for-free-to-un-officials/" target="_blank" rel="noopener noreferrer">an unvetted vaccine</a> nicknamed (double sigh) "Sputnik V." This vaccine has only concluded <a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30402-1/fulltext" target="_blank" rel="noopener noreferrer">phase 1 and 2 trials</a> with a small number of participants, yet Russia claims to have already received international requests. Meanwhile, China has administered <a href="https://www.reuters.com/article/us-health-coronavirus-china-vaccines-foc/in-coronavirus-vaccine-race-china-inoculates-thousands-before-trials-are-completed-idUSKBN26705Q" target="_blank" rel="noopener noreferrer">tens of thousands of doses of a vaccine</a> before completing phase 3 clinical trials. </p><p>An additional barrier to the United States' participation: COVAX is a WHO-led initiative. Earlier this year, <a href="https://www.npr.org/2020/05/29/865685798/president-trump-announces-that-u-s-will-leave-who" target="_blank" rel="noopener noreferrer">President Donald Trump admonished the WHO as a corrupt organization</a> and claimed it assisted China in covering up the coronavirus outbreak and its severity. Though he presented no evidence for the accusation, Trump has used it as the basis for <a href="https://www.statnews.com/2020/09/21/64-high-income-nations-join-effort-to-expand-global-access-to-covid-19-vaccines-but-u-s-and-china-do-not/" target="_blank" rel="noopener noreferrer">his threat to cut ties with</a>, and funding for, the agency.</p><p>"The United States will continue to engage our international partners to ensure we defeat this virus, but we will not be constrained by multilateral organizations influenced by the corrupt World Health Organization and China," said Judd Deere, a spokesman for the White House, said <a href="https://www.reuters.com/article/us-health-coronavirus-usa-who/white-house-slams-who-over-criticism-of-push-for-covid-19-vaccine-idUSKBN25S62T" target="_blank" rel="noopener noreferrer">in a statement</a>.</p><p>He added, "This president will spare no expense to ensure that any new vaccine maintains our own FDA's gold standard for safety and efficacy, is thoroughly tested, and saves lives."</p><p>By shirking COVAX, these countries hope to gain peerless access to a vaccine. Each could secure large numbers of doses for its citizens while also reaping the political boons to follow. In the United States, President Trump has pinned his re-election bid on a timely vaccine, while Chinese officials seem posed to use a vaccine <a href="https://www.nytimes.com/2020/09/11/business/china-vaccine-diplomacy.html" target="_blank" rel="noopener noreferrer">to repair diplomatic ties</a>. </p><p>But the loss of such rich economies will prove a blow to COVAX and the ACT Accelerator. Vaccines are notoriously expensive and risky to develop; the costs to manufacture doses at scale will be immense. <a href="https://news.un.org/en/story/2020/08/1070162" target="_blank" rel="noopener noreferrer">WHO Director-General Tedros Adhanom Ghebreyesus</a> stated the ACT Accelerator would cost roughly $30 billion, and the final bill for the tools to combat novel coronavirus would be at least $100 billion. But that's a pittance compared to the <a href="https://www.reuters.com/article/us-health-coronavirus-imf/imf-says-10-trillion-spent-to-combat-pandemic-far-more-needed-idUSKBN23I27P" target="_blank" rel="noopener noreferrer">$10 trillion already spent on the pandemic</a> so far.</p><p>"COVID-19 is an unprecedented global crisis that demands an unprecedented global response," <a href="https://www.who.int/news-room/detail/21-09-2020-boost-for-global-response-to-covid-19-as-economies-worldwide-formally-sign-up-to-covax-facility" target="_blank" rel="noopener noreferrer">Tedros said</a>. "Vaccine nationalism will only perpetuate the disease and prolong the global recovery. Working together through the COVAX Facility is not charity, it's in every country's own best interests to control the pandemic and accelerate the global economic recovery."</p>
The winner won't necessarily take all<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQzNzY2My9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NjExMzA1M30.2kF2U_8veNWxmaxOnSned_WTQMRtscbB5dmT5efJHsc/img.jpg?width=1245&coordinates=0%2C180%2C0%2C181&height=700" id="55cd7" class="rm-shortcode" data-rm-shortcode-id="c56717cda300a40edc23795c8ee23c2f" data-rm-shortcode-name="rebelmouse-image" alt="SARS-CoV-2 vaccine" />
Positive, romantic thoughts could produce positive, romantic outcomes while dating.
- Fear of rejection, self-doubt, and anxiety are just some of the obstacles humans need to overcome to make a meaningful, romantic connection with another person.
- According to a 2020 project by a group of psychologists at the University of Rochester (and the Israeli-based Interdisciplinary Center Herzliya), humans see possible romantic partners as a lot more attractive if they go into the interaction with a "sexy mindset."
- Across three separate studies, this team discovered that this sexual activation helps people initiate relationships by inducing them to project their desires onto prospective partners.
Being in a frisky mood improves your chances with potential romantic partners<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQzNzk0OC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0Mjc3MDA5NH0.lwJquRq9_gTYX5c_2sRzCBfkyWldjMqCJig_kGCL1uA/img.jpg?width=1245&coordinates=0%2C6%2C0%2C98&height=700" id="f2719" class="rm-shortcode" data-rm-shortcode-id="9a29ad6b50ff3868c867fd2d0a64b8aa" data-rm-shortcode-name="rebelmouse-image" alt="man and woman on date woman" />
The right mood could land you the right date, according to a new study.
Credit: BlueSkyImage on Shutterstock<p><a href="https://www.eurekalert.org/pub_releases/2020-09/uor-ffm092320.php" target="_blank" rel="noopener noreferrer">According to a 2020 study</a> by a group of psychologists at the University of Rochester (and the Israeli-based Interdisciplinary Center Herzliya), humans see possible romantic partners as a lot more attractive if they go into the interaction with a "sexy mindset."</p><p><a href="https://www.sas.rochester.edu/psy/people/faculty/reis_harry/" target="_blank" rel="noopener noreferrer">Harry Reis</a>, professor of psychology and the Dean's Professor in Arts, Sciences & Engineering at Rochester, and <a href="https://www.idc.ac.il/en/pages/faculty.aspx?username=birnbag" target="_blank" rel="noopener noreferrer">Gurit Birnbaum</a>, a social psychologist and associate professor of psychology at the IDC (Interdisciplinary Center Herzliya) have dedicated decades of their lives to studying the intricate dynamics of sexual attraction and human sexual behavior. </p><p>In <a href="https://www.rochester.edu/newscenter/relationships-uncertainty-are-you-really-in-to-me-323512/" target="_blank" rel="noopener noreferrer">a previous study,</a> the pair discovered that when people feel greater certainty about a romantic partner's interest, they put more effort into seeing that person again. Additionally, this study found people will rate the possible partner as more "sexually attractive" if they knew the person was interested in seeing them again.</p><p><a href="https://www.eurekalert.org/pub_releases/2020-09/uor-ffm092320.php" target="_blank" rel="noopener noreferrer">For this project</a>, Reis and Birnbaum, along with their team, examined what would happen if a person's sexual system is activated by exposing them to brief sexual cues that induced a thought process that included the potential for sex or heightened attraction. </p><p>Across three separate studies, the team discovered that this sexual activation helps people initiate relationships by inducing them to project their desires onto prospective partners. </p><p><strong>Study one: Immediacy</strong></p><p>In the first study, 112 heterosexual participants (between the ages of 20-32) who were not in a romantic relationship were randomly paired with an unacquainted participant of the opposite sex. Participants introduced themselves to each other (speaking about their hobbies, positive traits, career plans, etc.), all while being recorded. </p><p>The team then coded the recorded interactions and searched for nonverbal expressions of immediacy (such as close proximity, frequent eye contact, smiles, etc.) that could indicate interest in starting a romantic relationship. </p><p>In the study, the team determined that the participants exposed to a sexual stimulus before the meeting (versus those exposed to a neutral stimulus) exhibited more immediacy behaviors towards their potential partners and also perceived the partners as more attractive and/or more interested in them. </p><p><strong>Study two: Interest</strong></p><p>In the second study, 150 heterosexual participants (between the ages of 19-30) who were not in a romantic relationship served as a control for the potential partner's attractiveness and reactions. All participants in study two watched the same pre-recorded video introduction of a potential partner of the opposite sex. They then introduced themselves to the partner while being filmed themselves. </p><p>The researchers found that the activation of the sexual system led to participants viewing the potential partner as more attractive as well as more interested in them. </p><p><strong>Study three: How it all ties together</strong></p><p>In the third and final study, the team investigated whether a partner's romantic interest could explain why sexual activation impacts how we view other people's romantic interest in ourselves. </p><p>In this study, 120 single heterosexual participants (between the ages of 21-31) interacted online with another participant who was actually an attractive opposite-sex member of the research team. This was a casual "get-to-know-you" kind of interaction. The participants rated their romantic interest in the other person as well as that person's attractiveness and interest in them.</p><p>Again, the team found that sexual activation increased a person's romantic interest in the other person, which, in turn, predicted that the other person would then be more interested in a romantic partnership as well. </p><p><strong>The takeaway: Positive, romantic thoughts could produce positive, romantic outcomes. </strong></p><p>The basis of this multi-study theory is simple: Having active sexual thoughts arouses romantic interest in a prospective partner and often leads to an optimistic outlook on dating. </p><p>"Sexual feelings do more than just motivate us to seek out partners. It also leads us to project our feelings onto the other person," <a href="https://www.eurekalert.org/pub_releases/2020-09/uor-ffm092320.php" target="_blank">said Reis to Eurekalert</a>. </p><p>Reis goes on to explain, "...the sexual feelings need not come from the other person; they can be aroused in any number of ways that have nothing to do with the other person."</p>
New research conducted on mice suggests repeated heavy drinking causes synaptic dysfunctions that lead to anxiety.