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'Upstreamism': Your zip code affects your health as much as genetics
Upstreamism advocate Rishi Manchanda calls us to understand health not as a "personal responsibility" but a "common good."
- Upstreamism tasks health care professionals to combat unhealthy social and cultural influences that exist outside — or upstream — of medical facilities.
- Patients from low-income neighborhoods are most at risk of negative health impacts.
- Thankfully, health care professionals are not alone. Upstreamism is increasingly part of our cultural consciousness.
If you encounter the word "miasma" today, it's probably in reference to the worst level of a popular video game. But as late as the 19th century, medical science treated such "bad air" seriously. Under the purview of miasma theory, doctors believed that epidemics of diseases such as cholera and bubonic plague originated from noxious air wafting from decaying, rotting flesh.
Enter John Snow. Mapping an 1854 outbreak of cholera, Snow discovered that the afflicted shared a common environmental link. They all secured water from a pump on Broad Street in Soho, London. Snow theorized it was the water, not the miasmatic air, that caused the outbreak. He removed the pump's handle, nullified the spread of the disease, and proved his theory accurate.
Because of this, Snow is widely considered the father of epidemiology. Michael J. Dowling, president and CEO of Northwell Health, offers an additional honorific. He cites Snow as a "classic upstreamist," one whose example is important to understanding our struggles with upstreamism today.
What is upstreamism?
Upstreamism is a call for health care professionals to recognize that many of the determinants affecting a patient's health exist outside the medical facility — that is, upstream of it.
A clinician can prescribe medicine or offer advice when the patient is in their practice, but consider how much time the average person spends in a hospital and the like. Very little. Instead, the vast majority of a patient's life is spent upstream, in their environment, where many mental and physical health issues can manifest and potentially worsen.
If a health care professional is to be an upstreamist, they must equip themselves to assess and address these social and cultural determinants together with a patient's symptoms.
Rishi Manchanda, founder of HealthBegins and upstreamism advocate, says that "one's zip code matters more than your genetic code." In fact, he points out, epigenetics shows us that our zip codes can shape our genetic codes.
In his TED talk, Manchanda illustrates upstreamism with an anecdote about a patient named Veronica. Veronica suffered chronic, debilitating headaches. She had visited emergency rooms three times before trying Manchanda's clinic. The previous doctors looked at Veronica's symptoms in isolation, saw nothing wrong, and prescribed standard pain medication.
He measured the same vital signs, got the same results, but asked an additional question: what were her living conditions like? Turns out, her living conditions weren't ideal. Her housing had mold, water leaks, and cockroaches. Manchanda theorized that her condition may be the result of an allergic reaction to the mold, a diagnosis the others missed because they only considered Veronica's symptoms in isolation. They forgot to look upstream.
Swimming against the social current?
Volunteers beautify a park in Bowie, MD, as part of a three-year project to repair low-income neighborhoods in the county. (Photo: Staff Sgt. Alexandre Montes/U.S. Air Force)
Like an actual river, a patient's upstream environment doesn't flow in a straight line. In lieu of springs, streams, headwaters, and tributaries, a patient's constitutional watershed contains their social environment, their physical environment, their economic status, their individual lifestyle, and their access to care.
As a result, people living in low-income neighborhoods face far more negative social and cultural health influences than those living in wealthier areas. Patients from such environments are less likely to have access to pollutant-free water, full-service grocery stores and farmers markets, and parks and playgrounds. The stress of such environments leads to higher rates of depression, unresponsive parenting practices, and even increased rates of mortality.
"If you're living in a very, very good neighborhood, […] you will live years longer than the person who lives in a very, very poor area, in general," Dowling said in an interview. "So if I want to improve your health, I've got to make sure that I have doctors, and nurses, etc., to provide medical care to you. But I've also got to figure out how to work on all of these other things."
Mapping the upstream
The challenges of upstreamism would be daunting to health care professionals if they had to face them alone. However, we are in the midst of social changes that will make upstreamism viable. One of those changes is an always connected world where new information is available quickly.
Going back to Veronica's story, Manchanda didn't solve the problem alone. He connected her with a community health worker, and the partnership paid off. The community worker found mold, a strain Veronica was allergic to. Once her home conditions improved, Veronica's quality of life did as well. Manchanda inadvertently helped one of her sons, too, as his asthma was exacerbated by the same mold.
"If we're all able to do this work, doctors and healthcare systems, payers and all of us together, we'll realize something about health. Health is not just a personal responsibility or phenomenon. Health is a common good," Manchanda said in his TED talk.
Beyond search engines, technology companies are making a big push for health care. The tools and innovations they develop could streamline the mapping of a patient's upstream environment. For example, devices like smartphones and Fitbits may allow patients to generate their own health records, offering doctors a proactive, up-to-date account of a patient's environment. The growing ubiquity of such devices will also allow doctors to perform virtual health visits, giving them easy access to patients and their live-in environment.
Finally, many health care professionals and organizations are heeding the upstreamist call to use their voices to advocate for changes to harmful social influences. As part of the Greater New York Hospital Association, Northwell Health has supported actions to curb gun violence in the United States. They advocate for, among other steps, a renewed ban on assault rifles, enhanced background checks, and permitting the CDC and NIH to conduct research on gun violence.
"[G]un violence isn't just a national tragedy, it's also a public health crisis," writes Dowling in his book Health Care Reboot.
This brings us back to John Snow. If he hadn't looked to the environment, looked upstream, he may have missed a solution that saved people's lives. The problems facing upstreamists today may require solutions more taxing than removing a water pump handle. But through technology and changes in social attitudes, they are manageable and can have a lasting impact on health care.
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How a study on worms pointed the way towards a treatment for dementia
- An increasing amount of research suggests that failures in phase transition within cells can cause a variety of aliments
- The mechanism is believed to involve the inability of moleclues to move from solid to liquid and back, inhibiting cellular function.
- The discoveries open the door to treatments for neurodegenerative disease, some cancers, and other illnesses.
All matter is just going through a phase.<p>Think of liquid water for a moment. If you put it in the freezer, it'll turn to solid ice. Leave it out, and it will melt again. Boil it or leave it outside on a hot day, and it will all turn into water vapor eventually. This change in state is called a "<a href="https://chem.libretexts.org/Bookshelves/Physical_and_Theoretical_Chemistry_Textbook_Maps/Supplemental_Modules_(Physical_and_Theoretical_Chemistry)/Physical_Properties_of_Matter/States_of_Matter/Phase_Transitions/Fundamentals_of_Phase_Transitions#:~:text=Phase%20transition%20is%20when%20a,combination%20of%20temperature%20and%20pressure." target="_blank">phase transition</a>" and is familiar to most people who took some physics or chemistry. </p><p>Phase transition sometimes takes place in cells. Molecules inside cells responsible for cellular metabolism can change from solid to liquid to carry out specific tasks. However, it occasionally happens that the process that allows this to happen breaks down, and the molecules remain a little more solid than is ideal. This means that the molecules are no longer able to move around the cell and do their jobs. <br> <br> When this happens in certain cells in the brain, toxins associated with Alzheimer's disease and various other conditions start to build up in and around the cells. This discovery, based on previous studies from 2009, is the foundation of a theory on how neurodegenerative diseases start in our brains. </p>
How did scientists develop this theory?<div class="rm-shortcode" data-media_id="aBJpp9J4" data-player_id="FvQKszTI" data-rm-shortcode-id="134616cefd3c5c6b756c407590ea3f91"> <div id="botr_aBJpp9J4_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/aBJpp9J4-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/aBJpp9J4-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/aBJpp9J4-FvQKszTI.js"></script> </div> <p>In 2009, a group of scientists discovered phase transitions and their importance in worms' reproductive cells<a href="https://science.sciencemag.org/content/324/5935/1729.full#otherarticles" target="_blank"></a>. For reasons which are probably clear to you, this study didn't garner much attention right away. After a few years, the idea that glitchy phase transitions could cause a variety of issues gained some traction, and studies on phase transition in human brain cells took <a href="https://www.nature.com/articles/s41582-019-0157-5" target="_blank">place</a>. Dr. J Paul Taylor even won the <a href="https://www.potamkinprize.org/" target="_blank">Potamkin Prize</a>, awarded for excellence in dementia research, for work concerning how faulty phase transition relates to neurodegenerative diseases.</p>
What directions does this point in?<div class="rm-shortcode" data-media_id="cRIAffgd" data-player_id="FvQKszTI" data-rm-shortcode-id="ae687302c209d641b6e6395a8d8bff74"> <div id="botr_cRIAffgd_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/cRIAffgd-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/cRIAffgd-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/cRIAffgd-FvQKszTI.js"></script> </div> <p><a href="https://www.npr.org/sections/health-shots/2020/07/08/888687912/new-clues-to-als-and-alzheimers-from-physics" target="_blank">In his NPR interview,</a> Dr. Taylor suggests that treatments for Alzheimer's and related diseases based on this new understanding could be available in a few years. In the same article, Dr. Clifford Brangwyane of Princeton explained that some experimental treatments have already shown promise in correcting the issues. He also suggests that phase transition treatments could be used against other illnesses and perhaps even some cancers.</p><p>Sometimes tremendous scientific advances are born out of the strangest studies. In this case, a potential treatment for a variety of terrible neurodegenerative diseases traces its roots to a study of worms. More bizarre things have happened in science.</p>
A new study lays out the case for the damaging effects of stress on orcas living in tanks.
- There are currently around 60 orcas living in concrete tanks globally.
- Orcas' brain structures and behaviors strongly suggest smart, emotional, self-aware beings.
- The study provides compelling evidence that the stresses inherent in captivity do damage to these naturally free-roaming cetaceans.
A study, "The harmful effects of captivity and chronic stress on the well-being of orcas (Orcinus orca)" recently published in Journal of Veterinary Behavior is the product of a unique collaboration of experts in marine mammal science, veterinary science, internal medicine and psychiatry. It makes the case for a careful consideration of the impacts of chronic stress on captive orcas, at least 60 of whom are currently in captivity. Most have spent years or decades of their lives in these conditions. 56.7% of these orcas were born in captivity, with 26 captured young. (Orcas are actually the third most commonly confined cetaceans — there are even more bottlenose dolphins and beluga whales held in tanks.)
The study explains how the continual, oppressive stress inherent to a captive orca's life is unhealthy and should be more thoughtfully addressed. Study lead author biopsychologist Lori Marino tells Big Think in an email:
"Our review shows that intelligence, complexity, and awareness are characteristics that make an animal more — not less — vulnerable to the effects of captivity. That seems counterintuitive because a lot of people think that the more mental resources you have the better you are able to cope with various situations. But it is also the case that the more mental capacity you have the greater your needs in order to thrive and the more extreme the impact of living in an artificial environment, that is, an environment outside your adaptive envelope."
While skeptics may consider it a leap to assume that orcas are intelligent and emotional enough to suffer the ill effects of stress, Marino responds, "That would be a claim in search of evidence. Stress is a common phenomenon in all mammals and many other organisms. The effects of chronic stress have been well-studied in mice, rats, dogs, etc." The study provides ample evidence that orcas are exceptionally intelligent, feeling creatures in any event.
The orca brain
Image source: FineShine/Shutterstock
The orca brain exhibits neurobiological traits that are considered prerequisites for complex psychology, emotion, and behavior:
- a large brain size
- an expanded neocortex
- a well-differentiated cortical cytoarchitecture
- an elaborated limbic system.
Even more important than sheer brain size is its size in relation to an animal's body. This is captured as the organism's encephalization quotient, or EQ. Says the study, "Odontocetes, and in particular Delphinoidea [the superfamily to which orcas belong], are the most highly encephalized nonhuman taxonomic group known … except modern humans."
Orcas also have the most highly convoluted, or folded, neocortical surface of all mammals including humans, and their ratio of neocortical surface to brain weight also exceeds the human brain's, suggesting an organ well-suited to higher-order functions.
Among a range of other clues presented by the study that suggest orcas are highly intelligent creatures are these:
- Areas associated in the human brain with high-level cognitive and social functions including attention, prediction, social awareness, and empathy are all highly developed in orcas.
- Orcas have a well-integrated mammalian limbic system that supports having emotions, memory, motivation, reasoning, learning, and abstraction.
Image source: Willyam Bradberry /Shutterstock
Observations of orca behavior richly supports the implications of their neurobiological structures. Marino says, "Free-ranging orcas live in tightly-knit social groups that are necessary during their long juvenile periods and afterwards. They support each other, help each other when in trouble, and grieve each other. Mothers and calves are very tightly bonded. In some groups, male orcas stay with their mom their whole life and if mom dies [the male offpsring] may go into a deep depression and die as well. Family and social group are everything."
Orcas also demonstrate culture, with vocalizations and even hunting methods unique within groups and passed from generation to generation.
"Orcas at Punta Norte, Argentina, hunt sea lion and elephant seal pups by beaching themselves and capturing the pups, typically in the surf zone," according to the study.
Image source: Peter Etchells/Shutterstock
In the wild, free-ranging female orcas live an average of 46 years — some live as long as 90 years — and males 31 years, or as long as 50-60 years. Captive orcas rarely live more than 30 years, with many dying in their teens or 20s. Their medical histories can be difficult to access due to facilities' desire for confidentiality. Nonetheless, some morbidities, or causes of death, have become clear over time.
One review from 1979 identified infectious disease as the culprit behind the death of 17 captive North American orcas who'd died since 1965 prior to the report's writing. The new study cites publicly available documentation revealing that between 1971 and 2017, SeaWorld parks alone have experienced 35 documented orca deaths, and that, "When causes of death were available, the most commonly implicated conditions were viral, bacterial and fungal infections, gastrointestinal disease, and trauma."
Infections such as these may not in and of themselves have necessarily been lethal, but when combined with orcas' "weakened immune system, chronic exposure to chemical irritants or trauma to the skin, excessive or improper use of antimicrobials, and an imbalance in the microbiota of the body or environment (which may exist in tanks)," they become deadly. Common fungal infections may also especially dangerous in this context "as a result of long-term and aggressive antibiotic treatment, overtreatment of water for purity, or both." The same is true for untreated dental infections.
Another frequent cause of orca death: gastrointestinal ulceration — ulcers — caused by prolonged exposure to stress.
The destructive power of stress
Image source: eldeiv/Shutterstock
"Importantly, the poor health and short lifespans of captive orcas are most clearly understood as connected elements in a cycle of maladaptiveness to the conditions of captivity that involves behavioral abnormalities, physical harm and vulnerability to disease."
The paper shows, says Marino, that "when you examine the totality of the welfare findings for captive orcas the whole picture fits best within a larger common framework of evidence on how stress effects captive animals. We know that, when confined, other animals show the same kinds of behavioral and physiological abnormalities that captive orcas do. This is not mysterious or even controversial. It is basic science."
Marino cites as especially damaging the manner in which captivity prevents orcas from making social connections. Tanks also deprive them of places to retreat, making conflicts inescapable even temporarily. Finally, captive orcas are likely to become bored and chronically demotivated by the frustration over their loss of autonomy.
The study also notes physical effects brought on by long-term stress, including:
- the release of too much cortisol by the hypothalamus-pituitary-adrenal, or HPA, axis, causing elevated blood sugar, suppression of the immune system, as well as metabolism and blood pressure issues.
- alterations of the hippocampus, amygdala, and prefrontal cortex due to prolonged stress, potentially leading to Increased anxiety, post-traumatic stress, cognitive impairment, depression, and mood dysregulation.
- organ degradation in response to unrelenting stress.
- a loss of natural sensory information, about which, says the study, "a growing body of research has found that exposure to excessive or unnatural levels or types of acoustic input can cause a number of impacts to cetaceans, including but not limited to … accelerated aging, suppression of the immune response, as well as premature hearing loss."
A valuable conversation
Marino explains why it was important to conduct this study, saying, "My co-authors and I wrote this review to bring all of the available information on captive orca well-being together in one place and to suggest that we might all best be able to understand the effects of captivity within a very familiar and well-researched model of how chronic stress effects all organisms. We want this paper to be a catalyst for dialogue and further scientific exploration based on data as to how we can better understand who orcas are and how we can identify the important elements needed in a captive environment for them to thrive."
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