Pardis Sabeti Reveals the Future of Genomics
Harvard genomics professor Pardis Sabeti on the revolution happening in your body.
Filed under:
Medicine And Biology
Posted at:
06:43 AM on June 30, 2008
Rhodes scholar Pardis Sabeti graduated with her medical degree from Harvard Medical School in 2006, earning the school’s highest honor – the third woman ever to do so. She’s also the lead singer and songwriter of the band, Thousand Days, who uses her music to make science appealing to children, especially, girls. As a graduate student at Oxford University in England, Sabeti developed a way to detect natural selection at the level of individual genes. In Eric Lander’s lab at the Broad Institute, she scanned the entire human genome to figure out which genes have changed within the last 10,000 years and which have spread rapidly in the human gene pool due to natural selection. With these tools, geneticists can study how cultural and environmental changes have affected the evolution of the human genome. Now Sabeti is applying this technique to her true passion: understanding the interplay between humans and the pathogens that cause diseases like malaria, tuberculosis, and leprosy. Her work – published in December 2007 – revealed genes involved in drug resistance and in evading the immune system, giving researchers potential targets for new therapies and vaccines.
Read more about Dr. Pardis Sabeti »
Im an aspiring biotechnology major and I must say this is pretty interesting. Sequencing is a good step into figuring out the fuction of that good majority of unknown gene coding.
I would also think the matter of figuring out how genes have changed would be interesting, and that therapy for problems realted with genetics would be a major ethical issue since we don't have natural selection, and the whole matter delves into philosophy.
PS Contact is one of my favorite movies. :)
DNA information and its use can both help and hurt people. I see the the benefits in determining possible future disease and thus helping people plan and make health decisions, but I am not really sure if I want to know that I have a 50% chance of developing an incurable ailment. Are employers and insurers going to try to force employees undergo DNA testing to weed out people with possible future health problems? I see privacy issues here too. Amazing how people will use fantastic technology to try to discriminate. I predict genetic info cases will be making their way to the Supreme Court in the near future.