Everyone has grown up hearing fantasy stories about the "fountain of youth." We are still far from finding the fabled Fountain, but today the real question is quickly becoming “Would you really want to live forever?” With tremendous advances in the world of medicine, we will one day be able to drastically slow down the aging process in a human being. Scientists have already discovered over 70 individual genes that are directly involved with the human aging process. In worms, for example, we have already identified many of the genes that influence the aging process. You can actually change the life span of a worm like a light switch by changing their genome. Many people would immediately wonder why we would even want to slow down the aging process when we are overpopulated as it is. Well, the population in Europe for example is some sense imploding right now, with the average family having 1.5 children. Countries like Austria, Italy, Germany, Switzerland have populations that are essentially collapsing. So increasing prosperity and life spans has actually caused slowed down population growth.
Kings and queens of old have always wanted to live longer and discover the fountain of youth. This is actually how the state of Florida was discovered. Ponce de Leon heard Native Americans speak of a legendary, magical spring whose water was believed to make older people young again. While seeking the great, mythical and fabled fountain, his ships landed on Florida’s east coast near present-day St. Augustine. People have always been fascinated by the thought of being able to extend their days. Now, it may in fact be within our grasp within 20 to 30 years as we identify more and more genes involved in the aging process. If you take the genome of an older person and the genome of a younger person—in a computer you can compare the genomes and see where significant genetic changes are localized. We can further identify certain key genes that for example control the oxidation process and the biological clock.
(Below: Ponce De Leon on his quest for longevity)
Scientists are already experimenting with longevity processes in the laboratory. We can now put human skin cells in a petri dish and hit them with [telomerase, an enzume which prevents the telemeres of the chromosome from getting shorter, allowing the cell to divide indefinitely. (Telomeres are a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from deterioration). It was originally discovered in 1977 that the teleomere-shortening mechanism normally limits cells to a fixed number of divisions suggesting that this process is responsible for aging on the cellular level and sets a limit on life spans.
Of course, being able to expand this process out of the petri dish to something like the human body is beyond our capability at least for now. But in the future we may be able to:
- Reset the biological clock
- Slow down the oxidation process
- Increase cell repair mechanisms &
- Eliminate the build-up of genetic errors in the cell.
Below is an animated 3-dimensional molecular structure of a telomere
To be continued...