I find it very difficult to move forward with new ideas because of resistance and outright hostility from some groups.
Existing large institutions will not readily accept improvements to efficiency. One example being the teaching system and the teacher's unions and their non-acceptance of advanced teaching methods, such as tailoring education to the student's innate learning skills or abilities.
Another glaring example is the music industry and how they are trying to prevent the inevitable. Music should not be so expensive, it is only noises made by a few people, it does nothing to advance mankind. It has been made into a false commodity by greedy people.